This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.
In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).
The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.
Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.
Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Author(s): Moskalev, Alexey (Ed.)
Series: Healthy Ageing and Longevity
Publisher: Springer International Publishing
Year: 2019
Language: English
Pages: 415
Tags: longevity, aging, healthspan, lifespan
Front Matter ....Pages i-vii
Introduction (Alexey Moskalev)....Pages 1-4
Front Matter ....Pages 5-5
Practical Detection of Biological Age: Why It Is not a Trivial Task (Boris Veytsman, Tiange Cui, Ancha Baranova)....Pages 7-21
Biological Age is a Universal Marker of Aging, Stress, and Frailty (Timothy V. Pyrkov, Peter O. Fedichev)....Pages 23-36
Biomarkers of Health and Healthy Ageing from the Outside-In (Jonathan Sholl, Suresh I. S. Rattan)....Pages 37-46
Epigenomic, Transcriptome and Image-Based Biomarkers of Aging (Yizhen Yan, Yonglin Mu, Weiyang Chen, Jing-Dong J. Han)....Pages 47-66
An Overview of the Molecular and Cellular Biomarkers of Aging (I. A. Solovev, M. V. Shaposhnikov, Alexey Moskalev)....Pages 67-78
Front Matter ....Pages 79-79
IgG Glycans as a Biomarker of Biological Age (M. Vilaj, I. Gudelj, I. Trbojević-Akmačić, G. Lauc, M. Pezer)....Pages 81-99
Oxidatively Modified Proteins and Maintenance Systems as Biomarkers of Aging (Bertrand Friguet, Martin A. Baraibar)....Pages 101-120
Is Impaired Proteodynamics a Key to Understand the Biomarkers of Human Cellular Aging? (Jacek M. Witkowski, Ewa Bryl, Tamas Fulop)....Pages 121-134
Front Matter ....Pages 135-135
Genetic Markers of Extreme Human Longevity (Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Thomas T. Perls)....Pages 137-153
Epigenetic Biomarkers of Aging (Morgan E. Levine)....Pages 155-171
DNA Methylation Markers to Assess Biological Age (Dmitriy I. Podolskiy, Vadim N. Gladyshev)....Pages 173-183
Epigenetics of Brain Aging: Lessons from Chemo Brain and Tumor Brain (Anna Kovalchuk, Bryan Kolb, Olga Kovalchuk)....Pages 185-202
Approaches and Methods for Variant Analysis in the Genome of a Single Cell (Alexej Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi)....Pages 203-228
Front Matter ....Pages 229-229
Are There Reliable Biomarkers for Immunosenescence and Inflammaging? (Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M. Witkowski, Anis Larbi)....Pages 231-251
Immune Parameters Associated with Mortality in Longitudinal Studies of Very Old People Can Be Markedly Dissimilar Even in Apparently Similar Populations (Graham Pawelec, David Goldeck)....Pages 253-262
Gut Microbiota and Aging (Daria A. Kashtanova, Olga N. Tkacheva, Irina D. Strazhesko, Ekaterina N. Dudinskaya, Yu V. Kotovskaya, A. S. Popenko et al.)....Pages 263-278
Front Matter ....Pages 279-279
Deep Integrated Biomarkers of Aging (Polina Mamoshina, Alex Zhavoronkov)....Pages 281-291
Quantification of the Biological Age of the Brain Using Neuroimaging (James H. Cole, Katja Franke, Nicolas Cherbuin)....Pages 293-328
Arterial Aging: The Role of Hormonal and Metabolic Status and Telomere Biology (Irina D. Strazhesko, Daria A. Kashtanova, Ekaterina N. Dudinskaya, Olga N. Tkacheva)....Pages 329-348
Circulating Biomarkers of Aging (Hongxia Zhang, Brian Wang, Kunlin Jin)....Pages 349-371
Molecular Signature of Aging Driven by Wnt Signaling Pathway: Lessons from Nematodes (Marco Lezzerini, Yelena V. Budovskaya)....Pages 373-398
The Problem of Integrating of Biological and Clinical Markers of Aging (Arnold Mitnitski, Kenneth Rockwood)....Pages 399-415
Back Matter ....Pages 417-421
