Biological Nanostructures and Applications of Nanostructures in Biology: Electrical, Mechanical, and Optical Properties contains reviews and discussions of contemporary and relevant topics dealing with the interface between the science and technology of nanostructures and the science of biology. Moreover, this book supplements these past groundbreaking discoveries with discussions of promising new avenues of research that reveal the enormous potential of emerging approaches in nanobiotechnology. The topics include: - Biomedical applications of semiconductor quantum dots, - Integrating and tagging biological structures with nanoscale quantum dots, - Applications of carbon nanotubes in bioengineering, - Nanophysical properties of living cells, - Bridging natural nanotubes with fabricated nanotubes, - Bioinspired approaches to building nanoscale devices and systems, - Hairpin formation in polynucleotides. This state-of-the-art survey of key developments in nanotechnology - as they apply to bioengineering and biology - is essential reading for all academics, biomedical engineers, medical physicists, and industry professionals wishing to take advantage of the latest developments and highly-promising discoveries in nanoscience underlying applications in bioengineering and biology.
Author(s): Michael Stroscio
Edition: 1
Year: 2004
Language: English
Pages: 192
CONTENTS......Page 10
1. INTRODUCTION......Page 16
2. FABRICATING QUANTUM DOT SYSTEMS AND THEIR APPLICATIONS AS BIOTAGS......Page 18
3. RELEVANT PHYSICAL PROPERTIES OF SEMICONDUCTOR QUANTUM DOTS......Page 28
4. CONCEPTS AND TOOLS UNDERLYING THE INTEGRATION OF QUANTUM DOTS WITH BIOLOGICAL SYSTEMS......Page 32
6. ACKNOWLEDGMENTS......Page 43
7. REFERENCES......Page 44
1. INTRODUCTION......Page 52
2. OPTICAL AND ELECTRONIC PROPERTIES OF SEMICONDUCTOR QUANTUM DOTS......Page 53
3.1. Synthesis Techniques......Page 56
3.2. Capping of Quantum Dots......Page 58
4.1. Biocompatible Quantum Dots......Page 59
4.2. Quantum Dots for Biomedical Imaging Applications......Page 60
4.3. Quantum Dots for Bioassays and Biosensors......Page 62
7. REFERENCES......Page 63
1. INTRODUCTION......Page 66
2. CARBON NANOTUBES: BASIC PROPERTIES OF INTEREST IN THIS REVIEW......Page 67
3. POTENTIAL APPLICATIONS OF CARBON NANOTUBES FOR DRUG DELIVERY......Page 68
4. CHEMICAL FUNCTIONALIZATION OF CARBON NANOTUBES......Page 71
5. SOLUBILIZATION OF CARBON NANOTUBES......Page 75
6. BINDING PROTEINS TO NEURONS......Page 76
8. CONDUCTION IN MULTI-WALLED CARBON NANOTUBES......Page 78
9. RECENT DEVELOPMENTS IN CARBON NANOTECHNOLOGY......Page 79
11. CONCLUSION......Page 81
13. REFERENCES......Page 82
1. INTRODUCTION......Page 84
2.2. Cytoskeleton......Page 85
2.4. Fluid Flow......Page 86
3.2. Pharmacological Cytoskeleton Disrupting Agents......Page 87
4.1. Operation Principles......Page 88
4.2. Preparation of Cells for AFM Imaging......Page 89
4.4. AFM Probe Selection......Page 90
4.5. Scanning Modes......Page 92
5. TOPOGRAPHIC IMAGING OF LIVING CELLS WITH AFM......Page 93
6. FORCE IMAGING OF LIVING CELLS WITH AFM......Page 94
6.1. AFM in Cytoskeleton Imaging......Page 96
7.1. Cell Differentiation......Page 97
7.2. Fluid Flow Forces......Page 99
8.3. Results and Analysis......Page 102
10. REFERENCES......Page 104
1. INTRODUCTION......Page 114
2.1. Two-State Description......Page 116
2.2. Arrhenius Plots......Page 119
2.4. Zipper Model (with Misfolded States)......Page 120
3. REVIEW OF EXPERIMENTAL RESULTS AND PUZZLES......Page 121
3.1. Why is hairpin formation so slow?......Page 126
3.2. What is the activation enthalpy for the hairpin closing step?......Page 132
3.3. Is a semiflexible polymer description of ss-polynucleotides valid?......Page 135
3.4. What is the viscosity dependence of the opening and closing rates?......Page 142
3.5. Does transient trapping in misfolded states slow down hairpin formation?......Page 146
4. CONCLUSION......Page 153
6. REFERENCES......Page 155
1. INTRODUCTION......Page 164
2. NANOSTRUCTURES AS CORE COMPONENTS FOR BUILDING DEVICES......Page 166
3. BIOLOGY AS MODEL SYSTEM FOR BUILDING NANOSCALE DEVICES......Page 167
4. MICROBIAL SYSTEMS FOR ASSEMBLING NANOSTRUCTURES......Page 170
5. CURRENT STATE AND HIGHLIGHTS OF BIOAPPLICATIONS OF NANOSTRUCTURES......Page 172
7. ACKNOWLEDGEMENTS......Page 173
8. REFERENCES......Page 174
1. INTRODUCTION......Page 176
2. ION CHANNELS: WHAT THEY ARE AND HOW THEY ARE STUDIED......Page 177
3. POSSIBLE APPLICATIONS OF ION CHANNELS WITH CARBON NANOTUBES......Page 181
5. ACKNOWLEDGEMENT......Page 186
6. REFERENCES......Page 187
C......Page 190
L......Page 191
Q......Page 192
W......Page 193
