The revised and expanded second edition of Biological Inorganic Chemistry, winner of a 2013 Texty Award from the Text and Academic Authors Association, presents an introduction to this exciting and dynamic field. An increasing understanding of the importance of metals in biology, the environment and medicine, and the multiple roles of metal ions in biological systems, has given rise to biological inorganic chemistry as a field of study. The book begins with an overview of the concepts, both chemical and biological, required for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis, are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten, chromium and selected non-metals. The final five chapters provide a tantalizing view of the roles of metals in brain function, biomineralization, and a brief illustration of their importance in both medicine and the environment.Winner of a 2013 Textbook Excellence Awards (Texty) from the Text and Academic Authors Association. Readable style, complemented by anecdotes and footnotesEnables the reader to more readily grasp the biological and clinical relevance of the subjectColor illustrations enable easy visualization of molecular mechanisms
Author(s): Robert Crichton
Edition: 2
Publisher: Elsevier
Year: 2012
Language: English
Pages: 472
Tags: Биологические дисциплины;Биохимия;Бионеорганическая химия;
Front Cover......Page 1
Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function......Page 4
Copyright......Page 5
Contents......Page 6
Preface to the 2nd Edition......Page 12
INTRODUCTION......Page 14
WHY DO WE NEED ANYTHING OTHER THAN C, H, N, AND O (TOGETHER WITH SOME P AND S)?......Page 15
WHAT ARE THE ESSENTIAL ELEMENTS AND THE ESSENTIAL METAL IONS?......Page 16
AN IDIOSYNCRATIC VIEW OF THE PERIODIC TABLE......Page 20
REFERENCES......Page 31
TYPES OF CHEMICAL BONDS......Page 34
HARD AND SOFT LIGANDS......Page 36
COORDINATION GEOMETRY......Page 39
REDOX CHEMISTRY......Page 41
REFERENCES......Page 47
INTRODUCTION......Page 48
THE STRUCTURAL BUILDING BLOCKS OF PROTEINS......Page 50
PRIMARY, SECONDARY, TERTIARY, AND QUATERNARY STRUCTURE OF PROTEINS......Page 54
SECONDARY AND TERTIARY STRUCTURES OF NUCLEIC ACIDS......Page 63
REFERENCES......Page 81
INTRODUCTION......Page 82
INSERTION OF METAL IONS INTO METALLOPROTEINS......Page 89
CHELATASE – THE TERMINAL STEP IN TETRAPYRROLE METALLATION......Page 90
IRON–SULFUR CLUSTER FORMATION......Page 92
MORE COMPLEX COFACTORS – MOCO, FEMOCO, P-CLUSTERS, H-CLUSTERS, AND CUZ......Page 93
SIDEROPHORES......Page 99
REFERENCES......Page 102
INTRODUCTION......Page 104
REDOX REACTIONS IN METABOLISM......Page 105
THE CENTRAL ROLE OF ATP IN METABOLISM......Page 107
THE TYPES OF REACTION CATALYSED BY ENZYMES OF INTERMEDIARY METABOLISM......Page 109
AN OVERVIEW OF CATABOLISM......Page 110
SELECTED CASE STUDIES – GLYCOLYSIS AND THE TRICARBOXYLIC ACID CYCLE......Page 113
AN OVERVIEW OF ANABOLISM......Page 118
SELECTED CASE STUDIES: GLUCONEOGENESIS AND FATTY ACID BIOSYNTHESIS......Page 119
BIOENERGETICS – GENERATION OF PHOSPHORYL TRANSFER POTENTIAL AT THE EXPENSE OF PROTON GRADIENTS......Page 121
REFERENCES......Page 128
INTRODUCTION......Page 130
MAGNETIC PROPERTIES......Page 132
ELECTRON PARAMAGNETIC RESONANCE (EPR) SPECTROSCOPY......Page 133
MÖSSBAUER SPECTROSCOPY......Page 135
NMR SPECTROSCOPY......Page 137
ELECTRONIC AND VIBRATIONAL SPECTROSCOPIES......Page 138
RESONANCE RAMAN SPECTROSCOPY......Page 139
EXTENDED X-RAY ABSORPTION FINE STRUCTURE (EXAFS)......Page 140
X-RAY DIFFRACTION......Page 141
REFERENCES......Page 144
INORGANIC BIOGEOCHEMISTRY......Page 146
METAL ASSIMILATION IN BACTERIA......Page 150
METAL ASSIMILATION IN FUNGI AND PLANTS......Page 157
METAL ASSIMILATION IN MAMMALS......Page 164
REFERENCES......Page 166
METAL STORAGE AND HOMEOSTASIS IN BACTERIA......Page 168
METAL TRANSPORT, STORAGE, AND HOMEOSTASIS IN PLANTS AND FUNGI......Page 174
METAL TRANSPORT, STORAGE, AND HOMEOSTASIS IN MAMMALS......Page 183
REFERENCES......Page 188
INTRODUCTION – TRANSPORT ACROSS MEMBRANES......Page 190
SODIUM VERSUS POTASSIUM......Page 191
POTASSIUM CHANNELS......Page 193
THE SODIUM–POTASSIUM ATPASE......Page 197
ACTIVE TRANSPORT DRIVEN BY NA+ GRADIENTS......Page 200
SODIUM/PROTON EXCHANGERS......Page 203
OTHER ROLES OF INTRACELLULAR K+......Page 204
REFERENCES......Page 207
INTRODUCTION......Page 210
MAGNESIUM-DEPENDENT ENZYMES......Page 211
PHOSPHORYL GROUP TRANSFER KINASES......Page 212
PHOSPHORYL GROUP TRANSFER – PHOSPHATASES......Page 216
STABILISATION OF ENOLATE ANIONS – THE ENOLASE SUPERFAMILY......Page 217
ENZYMES OF NUCLEIC ACID METABOLISM......Page 218
MAGNESIUM AND PHOTORECEPTION......Page 223
REFERENCES......Page 226
THE DISCOVERY OF A ROLE FOR CA2+ OTHER THAN AS A STRUCTURAL COMPONENT......Page 228
AN OVERVIEW OF CA2+ REGULATION AND SIGNALLING......Page 229
CA2+ AND CELL SIGNALLING......Page 238
REFERENCES......Page 241
INTRODUCTION......Page 242
MONONUCLEAR ZINC ENZYMES......Page 243
MULTINUCLEAR AND COCATALYTIC ZINC ENZYMES......Page 251
ZINC FINGERS DNA- AND RNA-BINDING MOTIFS......Page 257
REFERENCES......Page 259
INTRODUCTION......Page 260
IRON AND OXYGEN......Page 261
BIOLOGICAL FUNCTIONS OF IRON-CONTAINING PROTEINS......Page 263
HAEMOPROTEINS......Page 264
OTHER IRON-CONTAINING PROTEINS......Page 280
DINUCLEAR NONHAEM IRON ENZYMES......Page 285
REFERENCES......Page 288
COPPER CHEMISTRY AND BIOCHEMISTRY......Page 292
COPPER-CONTAINING ENZYMES IN OXYGEN ACTIVATION AND REDUCTION......Page 295
MARS AND VENUS – THE ROLE OF COPPER IN IRON METABOLISM......Page 308
REFERENCES......Page 309
NICKEL ENZYMES......Page 310
METHYL-COENZYME M REDUCTASE......Page 315
B12-DEPENDENT ISOMERASES......Page 316
B12-DEPENDENT METHYLTRANSFERASES......Page 319
NONCORRIN CO-CONTAINING ENZYMES......Page 321
REFERENCES......Page 322
PHOTOSYNTHETIC OXIDATION OF WATER – OXYGEN EVOLUTION......Page 324
MN2+ AND DETOXIFICATION OF OXYGEN FREE RADICALS......Page 327
NONREDOX DI-MN ENZYMES – ARGINASE......Page 330
REFERENCES......Page 334
MO AND W CHEMISTRY AND BIOCHEMISTRY......Page 336
MOLYBDENUM ENZYME FAMILIES......Page 337
THE XANTHINE OXIDASE FAMILY......Page 338
THE SULFITE OXIDASES AND DMSO REDUCTASES......Page 341
REFERENCES......Page 354
THE MAJOR BIOGEOCHEMICAL CYCLES......Page 356
REFERENCES......Page 371
INTRODUCTION......Page 372
PRINCIPLES OF SOLID-STATE BIOLOGICAL INORGANIC CHEMISTRY......Page 373
AN OVERVIEW OF THE MAJOR CLASSES OF BIOMINERALS......Page 374
REFERENCES......Page 390
THE BRAIN AND THE BLOOD–BRAIN BARRIER (BBB)......Page 392
SODIUM, POTASSIUM, AND CALCIUM CHANNELS......Page 397
ZINC, COPPER, AND IRON......Page 401
REFERENCES......Page 407
METAL-BASED NEURODEGENERATION......Page 408
NEURODEGENERATIVE DISEASES ASSOCIATED WITH METALS......Page 414
REFERENCES......Page 427
DISORDERS OF METAL METABOLISM AND HOMEOSTASIS......Page 428
METAL-BASED DRUGS......Page 433
METALLOTHERAPEUTICS WITH LITHIUM......Page 438
CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING (MRI)......Page 440
REFERENCES......Page 444
INTRODUCTION ENVIRONMENTAL POLLUTION AND HEAVY METALS......Page 446
ALUMINIUM......Page 447
CADMIUM......Page 448
MERCURY......Page 452
LEAD......Page 453
METALS AS POISONS......Page 456
REFERENCES......Page 458
Index......Page 460
