Хорошая, объёмистая книга о биоинформатике на английском языке. В книге неплохо описаны основные концепции молекулярной биологии, популяционной генетики, статистики и конечно же приведено масса методов и концепций бионформатики.
Contents
1 Structure and Function of the Nucleus and Cell Organelles
2 Transcription and the Control of Gene Expression
3 RNA Processing and Translation
4 DNA Replication, Recombination, and Repair
5 Cell Signaling
6 Epigenetics of Spermiogenesis – Combining In Silico and Proteomic Approaches
in the Mouse Model
7 Genomic Tools for Analyzing Transcriptional Regulatory Networks
8 Probability and Hypothesis Testing
9 Stochastic Models for Biological Patterns
10 Population Genetics
11 Statistical Tools for Gene Expression Analysis and Systems Biology and Related Web Resources
12 What Goes in is What Comes Out: How to Design and Implement a Successful
Microarray Experiment
13 Tools and Approaches for an End-to-End Expression Array Analysis
14 Analysis of Alternative Splicing with Microarrays
15 An Introduction to Multiple Sequence Alignment — and the T-Coffee Shop. Beyond Just Aligning Sequences: How Good can you Make your Alignment, and so What?
16 A Spectrum of Phylogenetic-Based Approaches for Predicting Protein Functional Sites
17 The Role of Transcription Factor Binding Sites in Promoters and Their In Silico Detection
18 In Silico Discovery of DNA Regulatory Sites and Modules
19 Mining the Research Literature in Systems Biology
20 GoPubMed: Exploring PubMed with Ontological Background Knowledge
21 BiblioSphere — Hypothesis Generation in Regulatory Network Analysis
22 Biological Knowledge Extraction – A Case Study of iHOP and Other Language
Processing Systems
23 Using KEGG in the Transition from Genomics to Chemical Genomics
24 Ensembl – Open-Source Software for Large-Scale Genome Analysis
25 Management of Spatially Organized Biological Data using EMAGE
26 Equality of the Sexes? Parent-of-Origin Effects on Transcription and de novo Mutations
27 Methods for Structural Inference and Functional Module Identification in Intracellular Networks
28 Methods for Dynamical Inference in Intracellular Networks
29 ASIAN: Network Inference Web Server
30 Bioinformatics for Metabolomics
31 Virtual Reality Meets Functional Genomics
32 Systems Biology of Personalized Medicine
Author(s): Jon Holy, Ed Perkins (auth.), Stephen Krawetz (eds.)
Edition: 2
Publisher: Humana Press
Year: 2009
Language: English
Pages: 740
Tags: Bioinformatics
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Structure and Function of the Nucleus and Cell Organelles....Pages 3-31
Transcription and the Control of Gene Expression....Pages 33-49
RNA Processing and Translation....Pages 51-66
DNA Replication, Recombination, and Repair....Pages 67-87
Cell Signaling....Pages 89-104
Epigenetics of Spermiogenesis....Pages 105-117
Genomic Tools for Analyzing Transcriptional Regulatory Networks....Pages 119-136
Front Matter....Pages 137-137
Probability and Hypothesis Testing....Pages 139-150
Stochastic Models for Biological Patterns....Pages 151-162
Population Genetics....Pages 163-180
Statistical Tools for Gene Expression Analysis and Systems Biology and Related Web Resources....Pages 181-205
Front Matter....Pages 207-207
What Goes in is What Comes Out: How to Design and Implement a Successful Microarray Experiment....Pages 209-225
Tools and Approaches for an End-to-End Expression Array Analysis....Pages 227-265
Analysis of Alternative Splicing with Microarrays....Pages 267-279
Front Matter....Pages 281-281
An Introduction to Multiple Sequence Alignment — and the T-Coffee Shop. Beyond Just Aligning Sequences: How Good can you Make your Alignment, and so What?....Pages 283-313
A Spectrum of Phylogenetic-Based Approaches for Predicting Protein Functional Sites....Pages 315-337
The Role of Transcription Factor Binding Sites in Promoters and Their In Silico Detection....Pages 339-352
In Silico Discovery of DNA Regulatory Sites and Modules....Pages 353-366
Front Matter....Pages 367-367
Mining the Research Literature in Systems Biology....Pages 369-383
GoPubMed: Exploring PubMed with Ontological Background Knowledge....Pages 385-399
Front Matter....Pages 367-367
BiblioSphere — Hypothesis Generation in Regulatory Network Analysis....Pages 401-412
Biological Knowledge Extraction....Pages 413-433
Front Matter....Pages 435-435
Using KEGG in the Transition from Genomics to Chemical Genomics....Pages 437-452
Ensembl....Pages 453-467
Management of Spatially Organized Biological Data using EMAGE....Pages 469-484
Equality of the Sexes? Parent-of-Origin Effects on Transcription and de novo Mutations....Pages 485-513
Front Matter....Pages 515-515
Methods for Structural Inference and Functional Module Identification in Intracellular Networks....Pages 517-539
Methods for Dynamical Inference in Intracellular Networks....Pages 541-561
ASIAN: Network Inference Web Server....Pages 563-577
Front Matter....Pages 579-579
Bioinformatics for Metabolomics....Pages 581-599
Virtual Reality Meets Functional Genomics....Pages 601-613
Systems Biology of Personalized Medicine....Pages 615-630
Back Matter....Pages 631-639
