Bioinformatics brings computational methods to the analysis and processing of genomic data. Bioinformatics: Databases and Systems focuses on the issues of system building and data curation that dominate the day-to-day concerns of bioinformatics practitioners. Included are chapters by many of today's leading bioinformatics practitioners, describing most of the current paradigms of system building and curation, including both their strengths and weaknesses. Biological topics covered include sequence databases, metabolic pathways, phenotypes, variety collections, gene expression atlases and neuroinformatics. Species range from bacteria to mammals to plants. Software systems and technologies covered include OPM, CORBA, SRS, KLEISLI, ACEDB, Web-based integration and laboratory workflow. Bioinformatics: Databases and Systems provides a valuable introduction for newcomers to the field, and a useful reference for veterans.
Author(s): Stanley I. Letovsky
Edition: 1st
Publisher: Springer
Year: 1999
Language: English
Pages: 313
Tags: Биологические дисциплины;Матметоды и моделирование в биологии;Биоинформатика;
Preliminaries......Page 1
Introduction......Page 8
NCBI: Integrated Data for Molecular Biology Reserach......Page 20
HOVERGEN: Comparative Analysis of Homologous VerteBrate Genes......Page 30
WIT/WIT2: Metabolic Reconstruction Systems......Page 46
ECOCYC: The Resource and the Lessons Learned......Page 56
KEGG: From Genes to Biochemical Pathways......Page 72
OMIM: Online Mendelian Inheritance in Man......Page 86
GDB: Integrating Genomic Maps......Page 94
HGMD: The Human Gene Mutation Database......Page 108
SENSELAB: Modelling Heterogenous Data on the Nervous System......Page 114
The Mouse Genome Database and the Gene Expression Database: Genotype to Phenotype......Page 128
The Edinburgh Mouse Atlas: Basic Structure and Informatics......Page 138
FlyBase: Genomic and Post-Genomic Viewpoints......Page 150
MaizeDB: The Maize Genome Database......Page 160
AGIS: Using the Agricultural Genome Information System......Page 172
CGSC: The E.Coli Genetic Stock Center Database......Page 184
OPM: Object-Protocol Model Data Management Tools '97......Page 196
Biokleisli: Integrating Biomedical Data and Analysis Packages......Page 210
SRS: Analyzing and Using Data from Heterogenous Textual Databanks......Page 222
Biology Workbench: A Computing and Analysis Environment for the Biological Sciences......Page 242
EBI: CORBA and the EBI Databases......Page 254
Biowidgits: Reusable Visualization Components for Bioinformatics......Page 264
ACEDB: The ACE Database Manager......Page 274
LABBASE: Data and Workflow Management for Large Scale Biological Reseearch......Page 288
Index......Page 302
