The emergence of the Biochemical Sciences is underlined by the FAOB symposium in Seoul and highlighted by this Satellite meeting on the "New Bioenergetics. " Classical mitochondrial electron transfer and energy coupling is now complemented by the emerging molecular biology of the respiratory chain which is studied hand in hand with the recognition of mitochondrial disease as a major and emerging study in the basic and clinical medical sciences. Thus, this symposium has achieved an important balance of the fundamental and applied aspects of bioenergetics in the modern setting of molecular biology and mitochondrial disease. At the same time, the symposium takes note not only of the emerging excellence of Biochemical Studies in the Orient and indeed in Korea itself, but also retrospectively enjoys the history of electron transport and energy conservation as represented by the triumvirate ofYagi, King and Slater. Many thanks are due Drs. Kim and Ozawa for their elegant organization of this meeting and its juxtaposition to the FAOB Congress. Britton Chance April 2, 1990 v PREFACE This book contains the contributed papers presented at the "International Symposium on Bioenergetics: Molecular Biology, Biochemistry and Pathology", held in Seoul, Korea, August 18-21, 1989, sponsored by International Union of Biochemistry (as ruB Symposium No. 191) and Ewha Womans University, Seoul, Korea. The symposium was held in honor of Professor Kunio Yagi to commemorate his 70th birthday.
Author(s): Chong H. Kim (auth.), Chong H. Kim, Takayuki Ozawa (eds.)
Edition: 1
Publisher: Springer US
Year: 1991
Language: English
Pages: 484
Tags: Biophysics and Biological Physics; Biochemistry, general
Front Matter....Pages i-xii
Front Matter....Pages 1-1
Introductory Remarks....Pages 3-4
Opening Lecture....Pages 5-7
Front Matter....Pages 9-9
Memories of My Flavoprotein Research....Pages 11-22
Front Matter....Pages 23-23
An Overview of Ubiquinone Proteins....Pages 25-38
Studies on the Mechanism of Action of the Mitochondrial Energy-Linked Nicotinamide Nucleotide Transhydrogenase....Pages 39-48
Structures of Beef Mitochondrial Complex I Subunits....Pages 49-55
Inhibition of the Mitochondrial Complex I Activity by Fatty Acid Derivatives of Vanillylamide....Pages 57-63
New 4-Hydroxypyridine and 4-Hydroxyquinoline Derivatives as Inhibitors of NADH-Ubiquinone Oxidoreductase in the Respiratory Chain II....Pages 65-81
Effects of Redox State for Ubiquinone-10 on the Membrane Fluidity of Cardiolipin-Containing Liposomes....Pages 83-88
Features of Assembly and Mechanism of Yeast Mitochondrial Ubiquinol:Cytochrome C Oxidoreductase....Pages 89-109
Structural Studies of Euglena Cytochrome C 1 ....Pages 111-123
How Well is Cytochrome c Engineered?....Pages 125-145
Subunit I is the Catalytic Center of P. Denitrificans Cytochrome C Oxidase....Pages 147-154
The Separation between Cytochrome A and Cytochrome A 3 in the Absolute Spectrum....Pages 155-159
Which Electron-Transferring Reactions in the Respiratory Chain Contribute to the Energy Conservation?....Pages 163-170
Cytochrome Oxidase and Peroxide Metabolism....Pages 171-180
Do Hydrogen Ions Serve as Bioenergetic Messengers in Yeast?....Pages 181-190
Molecular Organization and Regulation of the Protonmotive System of Mammalian ATP Synthase....Pages 191-204
Situation of Archaebacterial ATPase among Ion-Translocating ATPases....Pages 205-216
Structure and Chemical Modification of Pig Gastric (H + +K + )-ATPase....Pages 217-225
Front Matter....Pages 23-23
Inhibition of the Uncoupler-Induced Mitochondrial ATP-Hydrolysis by the Cooperative Work of the ATPase Inhibitor, 9K Protein and 15K Protein....Pages 227-232
Reconstitution of H + ATPase into Planar Phospholipid Bilayers and Its Kinetic Analysis....Pages 233-240
A Mitochondrial Carrier Family for Solute Transport....Pages 241-249
The Calcium Pump of the Plasma Membrane: Structure/Function Relationships....Pages 251-258
The 9-kDa Polypeptide with Iron-Sulfur Centers A/B in Spinach Photosystem I with Special Reference to Its Structure and Topographic Consideration in Thylakoid Membrane....Pages 261-270
A Photo-Signal Transducing Photoreceptor (Stentorin) in Stentor coeruleus : A Brief Review....Pages 271-274
Theory and Applications of the Kinetics of Substrate Reaction during Irreversible Modification of Enzyme Activity....Pages 275-284
High Pressure Kinetic Studies on Certain Hemoproteins....Pages 285-293
The Purification and Properties of Glycerol-3-Phosphate Dehydrogenase in the Mitochondrial Inner Membrane....Pages 295-302
Front Matter....Pages 303-303
Subunit 8 of Yeast Mitochondrial ATP Synthase: Biochemical Genetics and Membrane Assembly....Pages 305-325
Gene Structure of Human ATP Synthase Beta Subunit....Pages 327-340
Molecule and Gene of Sulfolobus acidocaldarius ATPase....Pages 341-351
Nuclear Genes Encoding Two Subunits of Human Mitochondrial Cytochrome bc 1 Complex, Cytochrome c 1 and Ubiquinone-Binding Protein: Their Structural Organization of the 5′-Flanking Regions and Chromosomal Localization....Pages 353-362
Studies on the Function of the Mitochondrial Hinge Protein: Molecular Genetic Approach Using Yeast as a Model System....Pages 363-372
Molecular evolution and biology of human mitochondrial DNA....Pages 373-387
Front Matter....Pages 389-389
Stable and Unstable Bioenergetics in Vivo ....Pages 391-398
Regulation of Activity and Tissue-Specific Expression of Cytochrome C Oxidase Genes under Normal and Pathological Conditions....Pages 399-412
Mitochondrial DNA Mutations as an Etiology of Human Degenerative Diseases....Pages 413-427
Mitochondrial Myopathies: Morphological Approach to Molecular Abnormalities....Pages 429-439
S 1 Nuclease Analysis and Direct Sequencing of Deleted Mitochondrial DNA in Myopathic Patients: Role of Directly Repeated Sequences in Deletion....Pages 441-449
Front Matter....Pages 389-389
Thirty Years of Mitochondrial Pathophysiology: From Luft’s Disease to Oxygen Toxicity....Pages 451-465
Back Matter....Pages 467-484
