Biochemistry of Signal Transduction in Myocardium

Front Matter....Pages i-1
Front Matter....Pages 3-3
Phosphoinositide-generated messengers in cardiac signal transduction....Pages 5-14
Angiotensin II signalling pathways in cardiac fibroblasts: Conventional versus novel mechanisms in mediating cardiac growth and function....Pages 15-21
Signalling by cGMP-dependent protein kinases....Pages 23-30
Regulation of G protein function: Implications for heart disease....Pages 31-38
Regulation and functional significance of phospholipase D in myocardium....Pages 39-48
Mitogen-activated protein kinase (MAPK) in cardiac tissues....Pages 49-57
Phosphotransfer reactions as a means of G protein activation....Pages 59-63
Signalling by protein kinase C isoforms in the heart....Pages 65-72
Front Matter....Pages 73-73
Nitric oxide — a retrograde messenger for carbon monoxide signaling in ischemic heart....Pages 75-86
Expression of cardiac muscle markers in rat myocyte cell lines....Pages 87-91
Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions....Pages 93-99
The transphosphatidylation activity of phospholipase D....Pages 101-105
Reduction in G h protein expression is associated with cytodifferentiation of vascular smooth muscle cells....Pages 107-110
Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion....Pages 111-116
Sympathetic control of cardiac myosin heavy chain gene expression....Pages 117-124
Regulation of expression of cardiac sarcoplasmic reticulum proteins under pathophysiological conditions....Pages 125-128
Expression and regulation of chloride channels in neonatal rat cardiomyocytes....Pages 129-135
Paracrine functions of the coronary vascular endothelium....Pages 137-145
Front Matter....Pages 147-147
Mechanical effects of ET-1 in cardiomyocytes isolated from normal and heart-failed rabbits....Pages 149-155
Comparison of calcium-current in isolated atrial myocytes from failing and nonfailing human hearts....Pages 157-162
Front Matter....Pages 147-147
G-proteins and adenylyl cyclase signalling in hypertension....Pages 163-170
Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts....Pages 171-179
Regulation of expression of contractile proteins with cardiac hypertrophy and failure....Pages 181-189
β-Adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters....Pages 191-196
Front Matter....Pages 197-197
Polyunsaturated fatty acids and signalling via phospholipase C-β and A 2 in myocardium....Pages 199-210
Local renin-angiotensin systems....Pages 211-216
Metabolism of linoleic and α-linolenic acids in cultured cardiomyocytes: Effect of different N-6 and N-3 fatty acid Supplementation....Pages 217-222
Alpha-tocopherol pretreatment improves endothelium-dependent vasodilation in aortic strips of young and aging rats exposed to oxidative stress....Pages 223-228
Inositolpolyphosphates and their binding proteins — a short review....Pages 229-232
Prevention of late lumen loss after coronary angioplasty by photodynamic therapy: Role of activated neutrophils....Pages 233-238
Alpha-adrenergic reactivity of the microcirculation in conscious spontaneously hypertensive rats....Pages 239-244
Phosphodiesterase inhibition and Ca 2+ sensitization....Pages 245-249
Adrenergic and muscarinic receptor regulation and therapeutic implications in heart failure....Pages 251-258
Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease....Pages 259-267
Back Matter....Pages 269-274