Now the updated second edition of this bestselling title is available as softcover!
Intracellular signal transduction, regulation of cellular activities, tumor formation, apoptosis - how do they work? These questions have become a central topic in Biology and Biological Chemistry. The importance of this field is mirrored in the 1999 Nobel prize for Physiology that went to G. Blobel for his findings in protein transport regulation.
Over the last decade there has been great progress in the understanding of the molecular basis of signal transduction, and many facts are now basic knowledge for every medicinal chemist, biochemist, and biologist. Since an integral description of cellular regulation and signal transduction is scarcely covered in textbooks, this book fills a real gap. Starting from the principles of gene regulation and regulation of enzyme activity, the topics of this book cover function, structure, and integral construction of signalling pathways plus a detailed description of the various types of carriers such as second messengers, protein kinases, and transmembrane receptors. Central cellular processes like cell cycle regulation, oncogenesis and apoptosis are discussed in light of the properties of the signalling molecules involved. With didactic skill and clarity the author relates the observed biological phenomena to the underlying biochemical processes.
This book is actually two books: Regulation and Signal Transduction.
Content:
Chapter 1 The Regulation of Gene Expression (pages 1–88):
Chapter 2 The Regulation of Enzyme Activity (pages 89–118):
Chapter 3 Function and Structure of Signaling Pathways (pages 119–147):
Chapter 4 Signaling by Nuclear Receptors (pages 148–172):
Chapter 5 G?Protein Coupled Signal Transmission Pathways (pages 173–215):
Chapter 6 Intracellular Messenger Substances: “Second Messengers” (pages 216–246):
Chapter 7 Ser/Thr?Specific Protein Kinases and Protein Phosphatases (pages 247–285):
Chapter 8 Signal Transmission via Transmembrane Receptors with Tyrosine?specific Protein Kinase Activity (pages 286–323):
Chapter 9 Signal Transmission via Ras Proteins (pages 324–349):
Chapter 10 Intracellular Signal Transduction: the Protein Cascades of the MAP Kinase Pathways (pages 350–357):
Chapter 11 Membrane Receptors with Associated Tyrosine Kinase Activity (pages 358–376):
Chapter 12 Other Receptor Classes (pages 377–384):
Chapter 13 Regulation of the Cell Cycle (pages 385–419):
Chapter 14 Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes (pages 420–454):
Chapter 15 Apoptosis (pages 455–472):
Chapter 16 Ion Channels and Signal Transduction (pages 473–493):
