Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.
This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.
Author(s): Takashi Nagasawa, Nobuaki Tabata (auth.), James S. C. Gilchrist, Paramjit S. Tappia, Thomas Netticadan (eds.)
Series: Developments in Molecular and Cellular Biochemistry 42
Edition: 1
Publisher: Springer US
Year: 2003
Language: English
Pages: 185
Tags: Biochemistry, general
Front Matter....Pages i-v
Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative....Pages 3-10
Comparative analysis of the phenolic content of selected Chilean, Canadian and American Merlot red wines....Pages 11-19
Absence of ischemic preconditioning protection in diabetic sheep hearts: Role of sarcolemmal KATP channel dysfunction....Pages 21-30
Protein kinase B in the diabetic heart....Pages 31-38
Inhibition of interleukin-1β convertase is associated with decrease of neointimal hyperplasia after coronary artery stenting in pigs....Pages 39-43
Effects of MCC-135 on Ca 2+ uptake by sarcoplasmic reticulum and myofilament sensitivity to Ca 2+ in isolated ventricular muscles of rats with diabetic cardiomyopathy....Pages 45-51
Effect of sarpogrelate on altered STZ-diabetes induced cardiovascular responses to 5-hydroxytryptamine in rats....Pages 53-57
Mitogen-activated protein kinases in the acute diabetic myocardium....Pages 59-65
Association between coronary endothelial dysfunction and local inflammation of atherosclerotic coronary arteries....Pages 67-73
Arteriosclerosis in rat aortic allografts: Dynamics of cell growth, apoptosis and expression of extracellular matrix proteins....Pages 75-83
Effect of chronic treatment with losartan on streptozotocin-induced renal dysfunction....Pages 85-90
The relationship between human cytomegalovirus infection and atherosclerosis development....Pages 91-96
Changes in substrate metabolism in isolated mouse hearts following ischemia-reperfusion....Pages 97-103
A comparison between NMR and GCMS 13 C-isotopomer analysis in cardiac metabolism....Pages 105-112
Chronic diabetes alters function and expression of ryanodine receptor calcium-release channels in rat hearts....Pages 113-123
The relationship between QTc interval and cardiac autonomic neuropathy in diabetes mellitus....Pages 125-128
Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins....Pages 129-140
Native and minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinase levels....Pages 141-149
Low matrix metalloproteinase levels precede vascular lesion formation in the JCR:LA-cp rat....Pages 151-155
Impairment of glucose metabolism and energy transfer in the rat heart....Pages 157-165
Ischemic tolerance of rat hearts in acute and chronic phases of experimental diabetes....Pages 167-174
Remodelling of the sarcolemma in diabetic rat hearts: The role of membrane fluidity....Pages 175-182
Back Matter....Pages 183-188
