The success rate for treatment of primary neoplasms has improved sig nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care. In contrast, the treatment of cancer metastases, the cause of most cancer deaths, has not been very successful. Approximately 50% or more of patients with primary malignant neoplasms already have established metastases. Consequently, the most important problem in cancer treatment is the destruction or prevention of metastases. Metastases research has obvious clinical importance. Yet it has only been recently that investigators have attempted to study the mechanisms in volved in this process. This is in part due to the complexity of metastases formation. A metastatic colony is the result of a complicated series of steps involving mUltiple tumor host interactions. It is expected that multiple biochemical factors and gene products derived both from the host and the tumor cell may be required for the metastasizing tumor cell to invade, survive host defenses, travel in the circulation, arrest and adhere in the target organ, invade out, and grow as a metastatic colony. Some of these factors have recently been identified by investigators who have focused on individual steps in the metastatic process and have employed new technologies in immunology, biochemistry and molecular biology. The purpose of this volume is to capture some of the excitement in the field of metastases based on such new discoveries.
Author(s): Lance A. Liotta M.D., Ph.D. (auth.), Dr. Karoly Lapis, Dr. Lance A. Liotta, Alan S. Rabson (eds.)
Series: Developments in Oncology 41
Edition: 1
Publisher: Springer US
Year: 1986
Language: English
Pages: 334
Tags: Oncology; Biochemistry, general
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Biochemical and Molecular Biology Approaches to Study Cancer Metastases....Pages 3-10
Use of the Chick Embryo in Studying the Molecular Genetics of Metastasis....Pages 11-23
Integral Membrane Adhesion Glycoproteins: What is their Fate During Metastasis?....Pages 25-42
Peptide Fragments of Fibronectin and Laminin: Role in Cell Adhesion and Inhibition of Experimental Tumor Metastasis....Pages 43-53
Role of ras Oncogenes in Experimental Models of Metastasis....Pages 55-63
Expression of p21 ras Gene Products in Fresh Primary and Metastatic Human Tumor Tissue....Pages 65-72
A Role for Differentiation Arrest in the Development of Neural Crest Tumors....Pages 73-82
Genetic and Epigenetic Regulation of the Metastatic Phenotype: A Basis for Resolving the Controversy Regarding its Selective or Random Nature and Variable Phenotypic Stability....Pages 83-99
Cytochemical Cell Typing of Metastatic Tumors According to their Cytoskeletal Proteins....Pages 101-114
Biochemistry and Molecular Biology Raw117 Large Cell Lymphoma....Pages 115-127
Karyotypic Progression and Metastasis Formation of Human Tumors....Pages 129-136
Morphological and Functional Alterations of Occludens, Adherens, and Gap Junctions in Cancer....Pages 137-150
Pattern of Basement Membrane Degradation by Metastatic Tumor Cell Enzymes....Pages 151-163
Front Matter....Pages 165-165
Gene Products of the Major Histocompatibility Complex Control the Metastatic Phenotype of Tumor Cells....Pages 167-184
Generation of Metastatic Cells via Somatic Cell Fusion: A Possible Mechanism for Tumor Progression In-Vivo....Pages 185-198
The Recognition and Destruction of Metastatic Cells by Tumoricidal Macrophages....Pages 199-212
Biological Response Modifiers for the Therapy of Metastases....Pages 213-224
Differences in Cell Surface Characteristics of Poorly and Highly Metastatic Lewis Lung Tumor Variants....Pages 225-235
Characteristics of LL 2 and its Lectin-Resistant not Metastasizing Variants....Pages 237-249
A Role for Cell Surface Sialic Acid in Liberating Metastatic Tumor Cells from Host Control....Pages 251-262
Front Matter....Pages 263-263
Tumor Heterogeneity and Empirical Clinical Cancer Chemotherapy: Current Status and Future Prospects....Pages 265-278
Hormonal Regulation of Metastases: Prospects for Pharmacological Manipulation....Pages 279-292
Use of Anti-Tumor MABs for Diagnosis and Immunotherapy of Human Tumors....Pages 293-305
New Approaches to the Adoptive Immunotherapy of Established Metastatic Cancer using Lymphokine-Activated Killer Cells and Recombinant Interleukin-2....Pages 307-319
Preclinical Screening of Biological Response Modifiers: Application to the Treatment of Metastatic Disease....Pages 321-334
