This volume collects the papers presented at the "Second Euro pean Conference on Phagocytic Leucocytes" which was held in Trieste, September 15-18, 1980. The Conference was the continuation of the thread of a discourse initiated with the "First European Conference on Phagocytic Leucocytes," which was held also in Trieste in 1976. In fact, in both Conferences the biochemical aspects of the basic functions of phagocytes--that is movement, metabolism, secretion, and bactericidal activity--were mainly emphasized. In the Second Confer ence, two additional subjects were also dealt with, and those are the tumoricidal activity of phagocytes and the clinical aspects of phagocyte functions. In connection with the latter subject a "Round Table on the Clinical Application of Leucocyte Function Tests" was held during the Conference, and the proceedings are reported in this book in the hope that they may be useful to those who are interested in the relationship between phagocytes and diseases. The number of papers which are being published concerning the phagocytic process is such that one wonders whether publication of a new book in this field is necessary. However, the philosophy which inspired the edi ting of this book differs from that underlying publication of origi nal articles in scientific journals. We started from the common notion that the real progress of our knowledge is not necessarily proportional to the amount of published material in that specific field.
Author(s): P. Brederoo, J. van der Meulen, Charles E. McCall M.D. (auth.), Filippo Rossi, Pierluigi Patriarca (eds.)
Series: Advances in Experimental Medicine and Biology 141
Edition: 1
Publisher: Springer US
Year: 1982
Language: English
Pages: 699
Tags: Biochemistry, general
Front Matter....Pages i-xvi
Three Types of Granule Formed in Guinea Pig and Rat Heterophil Granulocytes....Pages 1-7
Leucocyte Activation and the Assessment of Leucocyte Locomotion and Chemotaxis....Pages 9-17
Distribution of Actin-Binding Protein and Myosin in Neutrophils During Chemotaxis and Phagocytosis....Pages 19-28
Interaction between Neutrophils and Mediators of Inflammation....Pages 29-37
A Short Transient Increase in Cyclic Adenosine 3′, 5′-Monophosphate Levels of Neutrophil Granulocytes Following Exposure to Chemotactic Factors....Pages 39-48
Neutrophil Migration and Orientation Under Agarose: Findings in Patients with the Immotile Cilia Syndrome and Effects of Cytochalasin B and Vinblastine....Pages 49-59
A Differential Responsiveness of In Vitro Differentiating Mononuclear Phagocytes from Bone Marrows of Normal and Inflamed Mice to Lymphokines and Poly I•Poly C....Pages 61-70
The Oxygen-Dependent Antibody-Dependent Cell-Mediated Cytotoxicity of Human Monocytes and Neutrophils....Pages 71-84
Macrophage Activation for Tumor Cytotoxicity: Reactivity of Peritoneal and Bone Marrow Macrophages....Pages 85-97
Cytotoxicity on Tumor Cells of Human Macrophages: Functional Status of Tumor-Associated Effector Cells....Pages 99-108
Studies on the Recognition of Xenogeneic Cells by Nonimmune Macrophages. II. Separate Signals Triggered Cytostasis and Cytolysis....Pages 109-118
Genetic Aspects of Macrophage Activation for Tumor Cytotoxicity....Pages 119-128
O 2 -Independent Killing of Gram-Negative Bacteria by Intact Granulocytes. The Role of a Potent Bactericidal Membrane-Perturbing Protein....Pages 129-137
The Extracellular Stimulation of Intracellular Killing by Phagocytes....Pages 139-149
Molecular Mechanism of the Bactericidal Action of Myeloperoxidase-H 2 O 2 -Chloride....Pages 151-160
The Role of the Cell Membrane in the Killing Mechanism of Polymorphonuclear Leucocytes (PMN)....Pages 161-165
Leptospires Macrophage Interactions....Pages 167-174
Relationship between the Enhanced Oxidative Metabolism and the Enhanced Microbicidal Activity of Activated Macrophages....Pages 175-177
Release of Superoxide Anion and Enhanced Candidacidal Activity as a Manifestation of Macrophage Activation: Studies with Muramyl Dipeptide....Pages 179-187
Killing of Leishmania Donovani Amastigotes by Murine Macrophages....Pages 189-198
Selective Depression of Phagocytes Intracellular Killing Activity....Pages 199-206
Modulation of the Inflammatory Response by the Neutrophil Myeloperoxidase System....Pages 207-216
Elastase Secretion by Mouse Peritoneal Macrophages: Effects of Rifampin and Corticosteroids....Pages 217-223
Synthesis and Release of Factor Increasing Monocytopoiesis (FIM) by Macrophages....Pages 225-232
Biochemical and Biological Characteristics of Leucocyte Proteinase Inhibitors....Pages 233-245
Oxidative Damage to Lysosomal Enzymes in Human Phagocytosing Neutrophils....Pages 247-257
The Release of Platelet-Activating Factor during Phagocytosis by Polymorphonuclear Neutrophils and Monocytes....Pages 259-268
The Secretion of Lysosomal Enzymes by Human Polymorphonuclear Leucocytes (PMN) and Its Modulation by Serum Complement....Pages 269-276
The Bovine Neutrophil: Separation and Partial Characterization of Plasma Membrane and Cytoplasmic Granules....Pages 277-281
The Respiratory Burst of Phagocytic Cells: Facts and Problems....Pages 283-322
Discrepancies in the Oxygen Balance of Whole Human Neutrophils and Neutrophil Homogenates....Pages 323-334
Neutrophil Activation Studied Using Two Indirect Probes of Membrane Potential Which Respond by Different Fluorescence Mechanisms....Pages 335-349
Formation of Superoxide Anions and Hydrogen Peroxide by Polymorphonuclear Leukocytes Stimulated with Cytochalasin....Pages 351-360
Hydrogen Peroxide Production in A Cell-Free System: Evidence for the Involvement of A Chain Reaction....Pages 361-370
The Respiratory Burst in Human Polymorphonuclear Leucocytes Stimulated by Particles....Pages 371-381
Stimulation of the Hexose Monophosphate Shunt Activity in Human Polymorphonuclear Leukocytes....Pages 383-392
The Nature and Function of the Microbicidal Oxidase System of Neutrophils....Pages 393-400
Chemiluminescence and the Study of Phagocyte Redox Metabolism....Pages 401-409
An Alternative Mechanism for the Production of Hydroxyl Radicals by Stimulated Neutrophils....Pages 411-421
Superoxide Dismutases and the Oxidative Burst in Human Blood Polymorphonuclear Leukocytes....Pages 423-427
Role of Serine Proteases in Superoxide Production by Human Neutrophils, Monocytes and Basophils....Pages 429-440
Release of the Membrane-Calcium and Its Relation to the Superoxide Formation by Polymorphonuclear Leukocytes....Pages 441-451
ATP-Driven Ca 2+ Pump Activity of Macrophage and Neutrophil Plasma Membrane....Pages 453-461
Ca 2+ Transport and Surface Membrane ATPase in Macrophages....Pages 463-472
Effect of Ionophores on Lymphocyte Cellular Metabolism....Pages 473-480
Peroxidatic Activity Distinct from Myeloperoxidase in Human Monocytes Cultured in Vitro and in Alveolar Macrophages....Pages 481-489
Characterization of the Peroxidase in Human Eosinophils....Pages 491-499
Stimulation or Activation of Eosinophils in Vivo during Eosinophilia: Possible Role of Arachidonic Acid Metabolism....Pages 501-508
Platelet Leukocyte Interactions II in-Vivo Correction of Chediak-Higashi Leukocyte Function with Serotonin or Normal Platelets....Pages 509-518
Physicochemical Surface Changes on Phagocytic Cells during Differentiation in Relation to Chemotaxis and Phagocytosis....Pages 519-530
Mechanism of Hexose Transport in Human Polymorphonuclear Leukocytes....Pages 531-538
Tuftsin and Substance P as Modulators of Phagocyte Functions....Pages 539-547
The Effect of Hyaluronic Acid on Neutrophil Function in Vitro and in Vivo....Pages 549-558
Expression of Fc And C3b Receptors and Intracellular Distribution of Bacteria in Rat Macrophages....Pages 559-565
Monocyte Activation by Immune Complexes of Patients with SLE....Pages 567-573
Nucleotide Concentrations in Leucocytes and Their Use in Controlling the Quality of Cell Preparations....Pages 575-582
Resting and Stimulated Chemiluminescence of Polymorphonuclear Leukocytes: A Clinical Approach....Pages 583-590
Deficient Phagocytosis Secondary to Breakdown of Opsonic Factors in Infected Exudates....Pages 591-601
Congenital and Acquired Lactoferrin Deficiencies in Neutrophils....Pages 603-610
Functional and Metabolic Abnormalities of Diabetic Monocytes....Pages 611-620
Enzymatic Deficiency in Monocytes from Patients with Chronic Granulomatous Disease....Pages 621-628
Use and Results of Neutrophil Function Testing in Pediatric Immunology....Pages 629-635
The Effect of Influenza Virus on Oxygen-Dependent Metabolism of Human Neutrophils....Pages 637-645
Chronic Granulomatous Disease, Kx Negative Neutrophils and Linkage with Xg ....Pages 647-654
Round Table on the Clinical Application of Leucocyte Function Tests....Pages 655-658
Back Matter....Pages 659-682
....Pages 683-699
