This book is the result of an international symposium held at the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The intent of this symposium was to provide an opportunity to compare the data on coronavirus structure and replica tion as well as to discuss mechanisms of pathogenesis. For over a decade coronaviruses have been recognized as an important group of viruses which are responsible for a variety of diseases of clinical importance in animals and man. Recently new and interesting data on the molecular biology and pathogenesis of coronaviruses have become available and this led us to organize this meeting. The uniformity and diversity in this virus group was evaluated from a molecular point of view and the replication of coronaviruses appears to involve aspects which may be unique for this virus group. Additionally, in contrast to other positive strand RNA viruses it became clear that coronaviruses readily establish persistent infections in the host, a phenomenon which may lead to the different subacute or chronic disorders manifested during coronavirus infection. This volume presents a series of articles based upon the scientific presentation given at the symposium. In addition, there are two articles by B. W. J. Mahy and D. A. J. Tyrrell which summarize the current state of art concerning the biochemistry and biology of coronaviruses, respective ly. We believe this book will be of interest to all virologists and particularly to both established workers and newcomers to this field. V.
Author(s): Lawrence S. Sturman (auth.), V. ter Meulen, S. Siddell, H. Wege (eds.)
Series: Advances in Experimental Medicine and Biology 142
Edition: 1
Publisher: Springer US
Year: 1981
Language: English
Pages: 438
Tags: Medical Microbiology
Front Matter....Pages i-x
The Structure and Behavior of Coronavirus A59 Glycoproteins....Pages 1-17
Structural and Antigenic Relationships between Human, Murine and Avian Coronaviruses....Pages 19-28
Antigenic Relationships of Coronaviruses Detectable by Plaque Neutralization, Competitive Enzyme Linked Immunoabsorbent Assay, and Immunoprecipitation....Pages 29-41
The RNA and Proteins of Human Coronaviruses....Pages 43-67
Genome Structure of Mouse Hepatitis Virus: Comparative Analysis by Oligonucleotide Mapping....Pages 69-82
The Structure of the Canine Coronavirus....Pages 83-90
Characterisation of Viral RNA in Cells Infected with the Murine Coronavirus JHM....Pages 91-101
Relatedness of Virion and Intracellular Proteins of the Murine Coronaviruses JHM and A59....Pages 103-110
Assembly of Mouse Hepatitis Virus Strain JHM....Pages 111-118
Glycoprotein E1 of Coronavirus A59: A New Type of Viral Glycoprotein....Pages 119-131
Analysis of the Functions of Coronavirus Glycoproteins by Differential Inhibition of Synthesis with Tunicamycin....Pages 133-142
Oligonucleotide Fingerprinting of the RNA of Different Strains of Infectious Bronchitis Virus....Pages 143-153
Coronavirus Cell-Associated RNA-Dependent RNA Polymerase....Pages 155-170
On Enteropathogenic Bovine Coronavirus....Pages 171-179
Polypeptide Structure of Bovine Enteritic Coronavirus: Comparison between a Wild Strain Purified from Feces and a HRT 18 Cell Adapted Strain....Pages 181-184
The Avian Coronavirus Multiplication Strategy....Pages 185-191
Intracellular Protein Synthesis and the in Vitro Translation of Coronavirus JHM mRNA....Pages 193-207
Messenger RNAs of Mouse Hepatitis Virus A59: Isolation and Characterization, Translation in Xenopus laevis Oocytes of RNAs 3, 6 and 7, UV Target Sizes of the Transcription Templates....Pages 209-225
Murine Coronavirus RNA....Pages 227-243
Comparison of the RNAs of Murine and Human Coronaviruses....Pages 245-259
Biochemistry of Coronaviruses 1980....Pages 261-270
In Vivo and in Vitro Models of Demyelinating Diseases....Pages 271-286
Evolution of a Coronavirus during Persistent Infection in Vitro ....Pages 287-299
Persistent Infection with Mouse Hepatitis Virus, JHM Strain in DBT Cell Culture....Pages 301-308
Characteristics of a Long Term in Vitro Persistent Infection with Human Coronavirus 229E....Pages 309-322
Coronavirus Antibodies in Patients with Multiple Sclerosis....Pages 323-326
JHM Infections in Rats as a Model for Acute and Subacute Demyelinating Disease....Pages 327-340
Host and Virus Factors Associated with CNS Cellular Tropism Leading to Encephalomyelitis or Demyelination Induced by the JHM Strain of Mouse Hepatitis Virus....Pages 341-348
Pathogenicity and Persistence of Mouse Hepatitis Virus in Inbred Strains of Mice....Pages 349-358
The Use of a Genetically Incompatible Combination of Host and Virus (MHV) for the Study of Mechanisms of Host Resistance ....Pages 359-373
Influence of the Immune System on the Course of Infection with Murine Coronavirus JHM in Suckling Mice....Pages 375-386
Macrophages and Resistance to JHM Virus CNS Infection....Pages 387-398
Vomiting and Wasting Disease, a Coronavirus Infection of Pigs....Pages 399-408
Inborn Resistance of Mice to Mouse Hepatitis Virus Type 3 (MHV 3 ): Liver Parenchymal Cells Express Phenotype in Culture....Pages 409-417
Biology of Coronaviruses 1980....Pages 419-425
Back Matter....Pages 427-438
