Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach covers herbal medicines from the Himalayan mountains. Chapters in this book detail molecular mechanisms and experimental tools and techniques for research on plants in this region. Phytochemical experts guide the readers through the role of Himalayan plants in therapy for metabolic diseases like cancer and diabetes, hepatic diseases, inflammatory diseases, and neurodegenerative diseases. Some chapters focus on diseases and how various plants from Himalayan origin are beneficial in these diseases.
This compilation,with professional contributors, aims to inform a wide scientific community from various research fields about basic research on medicinal plants with a focus on Himalayan herbs. The book also serves as a handbook for pharmacologists working on the broad therapeutic aspects of these plants.
Author(s): Manish Kumar, Praveen Kumar, Ashita Sharma
Publisher: Bentham Science Publishers
Year: 2023
Language: English
Pages: 198
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
List of Contributors
Anticancer Phytochemicals from the Himalayas: Underlying Mechanisms and Chemopreventive Significance in Cancer
Anjana Bhatia1, Saroj Arora2, Bikram Singh3 and Avinash Nagpal2,*
INTRODUCTION
THE INDIAN HIMALAYAS: A TREASURY OF MEDICINAL PLANTS
Hypericum Perforatum Linn.
Phytochemicals from Hypericum Perforatum and their Cancer Chemopreventive Activities
Juniperus sp.
Phytochemicals from Juniperus sp. and their Cancer Chemopreventive Activities
Lavandula sp.
Phytochemicals from Lavender and Cancer Chemoprevention
Pinus sp.
Phytochemicals from Pinus and their Cancer Chemopreventive Activities
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Hepatoprotective Molecules from Himalayan Plants and their Role in Xenobiotic Mechanisms: A Tabulated Review
Kritika Pandit1, Amritpreet Kaur1, Manish Kumar2, Renu Bhardwaj1 and Satwinderjeet Kaur1,*
INTRODUCTION
CONCLUSION AND FUTURE PERSPECTIVES
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Himalayan Herbs: A Promising Medication Source for Neurodegenerative Diseases
Sippy Singh1,* and Durgesh Singh1
INTRODUCTION
NEURODEGENERATIVE DISEASES
AYURVEDA IN TREATING NEURODEGENERATIVE DISEASES
PLANTS OF THE HIMALAYAN REGION
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Antidiabetic Role of Swertia chirayita: Phytochemical and Pharmacological Perspective of a Himalayan Botanical
Nikhil Pandey1, Priyanka Mishra1 and Yamini B Tripathi1,*
INTRODUCTION
PHYTOCHEMISTRY OF SWERTIA CHIRAYITA
ANTIDIABETIC PROPERTIES OF SC
CONCLUSION AND FUTURE PERSPECTIVES
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Health Promoting Properties of Grewia asiatica and Grewia tenax Berries: A Potential Role in Cancer, Diabetes, and Liver Diseases Prevention
Ankita Rajput1, Palvi Sharma1, Hasandeep Singh2, Balbir Singh2, Sarabjit Kaur2,* and Saroj Arora1,*
INTRODUCTION
Grewia Tenax (Forsk.) Fiori
Traditional Uses
Phytoconstituents
Pharmacological Activity
Iron Absorption Activity
Hepatoprotective Activity
Blood Parameters
Grewia Asiatica L
Traditional Uses
Phytoconstituents
Pharmacological Activity
Antioxidant Activity
Radioprotective Activity
Antipyretic, Anti-inflammatory and Analgesic Activities
Effect on Blood Alterations
Hepatoprotective Activity
Anticancer Activity
Antidiabetic Activity
Antimicrobial Activity
Immunomodulatory Effect
Anti-dementia
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Medicinal Value of Atropa belladonna L.: A Therapeutic Approach against Various Diseases
Palvi Sharma1, Ankita Rajput1, Sukhprit Singh2, Neena Bedi3, Balbir Singh3 and Saroj Arora1,*
INTRODUCTION
PLANT PROFILE
Common Names
Description
Distribution
Traditional Uses
PHARMACOLOGICAL EFFECTS
Antioxidant Activity
Neuro-pharmacological Effects
Anti-inflammatory Effect
Skin Wound Healing
Antimicrobial Activity
Anticholinergic Activity
Pain Relief and Sedation
Anticonvulsant Activity
CHEMICAL CONSTITUENTS
TOXICITY AND SIDE EFFECTS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Pharmacological, Therapeutic, and Immunomodulatory Role of Tinospora cordifolia
Naina Rajak1, Kavita1, Praveen Kumar1, Shikha Singh2 and Neha Garg1,*
INTRODUCTION
BIOACTIVE PROPERTIES OF TC EXTRACTS
PHYTOCHEMISTRY AND PHARMACOLOGICAL ASPECTS OF TC
Chemical Composition
Pharmacological Activity of Tinospora cordifolia
Anti-cancer Activity
Anti-diabetic Activity
Anti-toxin Activity
Anti-microbial Activity
Anti-HIV Activity
Anti-arthritic Activity
Immunomodulatory Activity
Immunomodulatory Activity of TC: Role of Berberine
Colorectal Cancer
CONCLUSION AND FUTURE PERSPECTIVES
LIST OF ABBREVIATIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Immunomodulatory Potential of Himalayan Plant: Withania somnifera
Kavita1, Naina Rajak1, Praveen Kumar1, Shikha Singh2 and Neha Garg1,*
INTRODUCTION
PHYTOCHEMISTRY AND THERAPEUTIC ACTIVITIES OF ASHWAGANDHA
Chemical Composition
Therapeutic Activities of Withania somnifera
Anti-arthritis Activity
Anti-diabetic Activity
Anti-inflammatory Activity
Antineoplastic Agent
Anti-oxidant Activity
Anti-stress Activity
Hemopoietic Effect
Rejuvenation Activity
Neuromodulatory Activity
IMMUNOMODULATORY POTENTIAL OF WITHANIA SOMNIFERA
Immunomodulatory Activity of Withaferin A
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Medicinal Plants from the Himalayas Acting on Inflammatory and Oxidative Stress Pathways
Priyanka Mishra1, Nikhil Pandey1 and Yamini B Tripathi1,*
INTRODUCTION
THE LINK AMONG OXIDATIVE STRESS, INFLAMMATION AND CELLULAR PATHOLOGY
Medicinal Plants Acting on the Inflammatory Pathway from the Himalayan Range
MEDICINAL PLANTS ACTING ON OXIDATIVE STRESS PATHWAY FROM THE HIMALAYAN RANGE
Molecular Pathways Affected
CONCLUSION AND FUTURE PERESPECTIVES
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Phytochemical Databases and their Relevance to Phytotherapy
Shagun Shagun1 and Shyam Kumar Masakapalli1,*
INTRODUCTION
PHYTOCHEMICAL DATABASES
a). Region Specific Databases of Medicinal Plants and Phytochemicals
b). Disease-specific Medicinal Plants and Phytochemical Databases
c). Other Common Medicinal Plants and Phytochemical Databases
d). Himalayan Region-specific Medicinal Plants and Phytochemical Databases
PHYTOCHEMICAL DATABASES COMPLEMENT PHYTOTHERAPY RESEARCH
DATABASES WITH RELEVANCE TO HIMALAYAN PHYTOCHEMICALS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Tools and Techniques to Tap the Potential of Himalayan Bioactive Molecules
Shagun Shagun1 and Shyam Kumar Masakapalli1,*
INTRODUCTION
PROFILING OF PHYTOCHEMICALS FROM HIMALAYAN FLORA
1. Extraction of Phytochemicals
2. Multi-analytical Platforms Used for the Identification of Phytochemicals
MOLECULAR DOCKING OF THE PHYTOCHEMICALS FROM HIMALAYAN FLORA TO VARIOUS DISEASE TARGETS
MOLECULAR DYNAMICS SIMULATION AND BINDING FREE ENERGY CALCULATIONS
ASSESSMENT OF ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION, AND TOXICITY PROPERTIES
BIOACTIVITY TESTING OF CRUDE EXTRACTS OR SELECTED PHYTOCHEMICALS
In Vitro Assays
In vivo Assays and Clinical Trials
CASE STUDY: MOLECULAR DOCKING STUDY OF THE PHYTOCHEMICALS FROM HIMALAYAN FLORA TO MYCOBACTERIUM TUBERCULOSIS POLYKETIDE SYNTHASE-13 (MTB-PKS 13)
SELECTED PHYTOCHEMICALS FROM HIMALAYAN FLORA FOR DOCKING AGAINST PKS-13 OF MTB
Himalayan Rhododendron arboreum Petals Phytochemicals Showed Promising Binding Affinities Against Mycobacterium tuberculosis Polyketide Synthase-13
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover
