Bee Products and Their Applications in the Food and Pharmaceutical Industries focuses on the health benefits of selected bee products by looking more closely at their pharmacological potentials and therapeutic applications in coping with various diseases. The book explores some of these products, such as royal jelly, propolis and bee venom, which is highly attractive to the food supplement sector due to the biological actions that are proved by scientific studies. Bee products also attract the cosmetics industry by utilizing those products in various applications such as hair products, toothpaste, sunscreen creams, lip balsams, or facial moisturizing creams.
Each chapter focuses on a particular health benefit, providing more compact and detailed information about each activity for a specific interest. The mainframe of the book is based on the medicinal and pharmacological functions of bee products, with the therapeutic applications for each bee product supporting the mechanism of action of their biological functions.
Author(s): Dilek Boyacioglu
Edition: 1
Publisher: Academic Press
Year: 2022
Language: English
Pages: 464
City: New York
Front Cover
Bee Products and Their Applications in the Food and Pharmaceutical Industries
Copyright
Dedication
Contents
Contributors
Preface
Chapter 1 Bee products—An overview of their pharmacological properties and medicinal applications
Introduction
Complementary and alternative medicine
Bee product pharmacology
Ethical considerations with the use of bee products
Problems of holistic apitherapy
Bias in interpretation of scientific data
Acceptance of bee products as medicine
Possibilities for uses of bee products in medicine
Treatment of various types of wounds
Wound infections
Tonsillectomy
Diabetic foot ulcers
Radiotherapy and/or chemotherapy-induced oral mucositis
Burns
Malignant fumigating wounds
Herpes virus-associated skin lesions (HSV-1, HSV-2)
Honey for acute coughs in children
Oral health—Dental plaque and gingival inflammation
Poststroke shoulder pain
Musculoskeletal pain
Bee products must be superior to other approaches
Bringing bee products back into medicine—Discussion and concluding remarks
References
Chapter 2 Bee products and skin therapy
Introduction
Honey
Types of honey
The role of honey constituents
Therapeutic properties of honey
Propolis
Propolis against photodamage of skin
Antimicrobial properties of propolis against infections
Wound healing properties of propolis
Bee pollen
Bee pollen and skin products
A cosmetic ingredient for hair products
Burn healing properties
Royal jelly
Royal jelly in skin care
Therapeutic effects of royal jelly
Beeswax
Beeswax in cosmetics
Beeswax in skin care
Antimicrobial effects of beeswax
Antioxidative and antiinflammatory activity of beeswax
Bee venom
Cosmetic applications of bee venom
Pharmacological value of bee venom
Conclusion
References
Chapter 3 Bee products and diabetes mellitus
Introduction
Preclinical studies on the antidiabetic potential of bee products
Blood glucose, Hb1Ac, and lipid profiles
Insulin deficiency
Oxidative stress and insulin resistance
Preclinical studies of bee products on diabetic complications
Diabetic nephropathy
Diabetic retinopathy
Delayed wound healing
Clinical studies involving bee products
Conclusion
References
Chapter 4 Propolis and the immune system
Introduction
Phytochemicals of propolis responsible for immunomodulatory action
Overview of the immune response
Immunomodulatory effects on innate and adaptive immunity
Effects on innate immunity
Effects on phagocytes, NK cells, and cytokines
Effects on dendritic cells and cytokines
Effects on adaptive immunity
Conclusion
References
Chapter 5 Propolis and gastrointestinal tract diseases
Introduction
Phytochemical constituents of propolis
Effect of propolis on oral mucositis
Effect of propolis on gastrointestinal cancers
Mechanism of action of propolis on cancer cells
Research on development of pharmaceutics
Antiulcer activity of propolis
Mechanism of action of propolis on gastric ulcers
Efficacy of propolis on H. pylori
Effect of propolis on inflammatory bowel disease
Conclusion
References
Chapter 6 Potential of propolis against SARS CoV-2 coronavirus infection
Introduction
Antiviral properties of propolis
Possible paths of action of propolis against COVID-19
Effects on angiotensin-converting enzyme 2 (ACE-2) receptor binding
Blocking of protein kinases
Inhibition of proteases
Immunomodulatory activity
Adjuvant efficiency
Efficiency against septic shock
Antithrombosis activity
Conclusion
References
Chapter 7 Effect of propolis on fungi of human clinical interest
A modern portrait of human fungal infections
Tegumentar infections
Mucosal infections
Invasive fungal infections (IFIs)
Fungal virulence attributes
Insights on treatment of human fungal infection
Propolis
Botanical origin
Chemical composition
Physicochemical characteristics
Products, by-products, and formulations
Biological properties of propolis for human health
Pharmacological properties
Antifungal properties
Mechanisms of propolis antifungal action
Propolis cytotoxicity and mutagenic potential
Propolis perspectives for prevention or treatment of fungal infections
Propolis on cutaneous fungal infections
Propolis on mucosal fungal infections
Propolis in the prevention of systemic fungal infections and potential use in the coating of medical devices
Conclusion
References
Chapter 8 Royal jelly and fertility
Introduction
The effects of royal jelly on fertility in experimental animal models
Effect of royal jelly on female fertility in rodents
Effect of royal jelly on male fertility in rodents
Fertility-improving effect of royal jelly in farm animals
Chickens
Rabbits
Buffaloes
Sheep
Royal jelly and human fertility
Beyond royal jelly: The effect of drone milk on fertility
The effect of drone milk on male rats
The effect of drone milk on female rats
Conclusions
References
Chapter 9 Prevention of side effects from chemoradiotherapy and antitumor potential of royal jelly and its components: A s ...
Introduction
Materials and methods
Data source and search strategy
Inclusion and exclusion criteria
Selection of articles and quality assessments
Data analysis
Results
Characteristics of selected studies
Preclinical cell studies
Breast cancer
Colorectal adenocarcinoma
Hepatocellular carcinoma
Lung cancer
Vascular endothelial growth factor (VEGF)-induced angiogenesis
Preclinical animal studies
Breast cancer
Leukemia
Prevention of side effects—Hepatotoxicity
Prevention of side effects—Mucositis
Prevention of side effects—Prostatic tissue damage
Prevention of side effects—Spermiotoxicity
Effect of RJ on the human models
Clinical trials with RJ for oncologic treatments
Leukemia
Effect of RJ on treatable symptoms from oncologic treatments
Cancer-related fatigue
Cancer-related fatigue and anorexia
Eating difficulty
Inflammation
Mucositis
Nephrotoxicity
Inflammation and decrease of immunity
Discussion
Conclusion
Acknowledgments
References
Chapter 10 Royal jelly: Healthy aging and longevity
Introduction
Royal jelly
Aging process
Evaluation of royal jelly studies on healthspan and lifespan
Apis mellifera studies
A nematode model study: Caenorhabditis elegans
A yeast model study: Saccharomyces cerevisiae
A multicellular organism model study: Drosophila melanogaster
Rodent model studies: Rat and mice
Conclusion
References
Chapter 11 Bee pollen in cosmetics: The chemical point of view
Introduction
Bee pollen as a nutritional and health-promoting agent
Bee pollen as a source of antioxidants
Lipophilic/hydrophilic character of bee pollen
Skin and skincare cosmetics
Selected compounds from bee pollen as skincare cosmetics components
Quercetin and derivatives
Vitamin C ( l -ascorbic acid)
Vitamin E (tocopherols)
Apigenin and derivatives
Zinc and selenium
Conclusion
References
Chapter 12 Pollen and bee bread and liver health
Introduction
Chemical composition and active components of pollen and bee bread
Effects of pollen and bee bread on liver enzymes and diseases
Liver enzymes
Hepatitis and hepatotoxicity
Nonalcoholic fatty liver disease (NAFLD)
Alcoholic liver disease (ALD)
Cirrhosis
Hepatocellular carcinoma
Safety considerations of pollen and bee bread
Future pollen and bee bread research
Conclusions
References
Chapter 13 Bee bread and gut microbiota
Introduction
Chemical composition of bee bread
Moisture
Proteins and amino acids
Lipids
Ash content and minerals
Carbohydrates
Phenolic compounds
Compounds related to aroma and flavor
Vitamins
Biochemical principles related to bee bread production in the hives
Microorganisms involved in bee bread production
Functional potential of bee bread on gut microbiota
Simulation of production of bee bread from bee pollen
Conclusion
References
Chapter 14 Therapeutic application of bee venom for rheumatoid arthritis
Introduction
Historical context
Type of application method of bee venom therapy
Pharmaceutical properties and medical uses of bee venom
Bioactive compounds in bee venom
Therapeutic applications
Bee venom therapy for rheumatoid arthritis
In vivo studies for rheumatoid arthritis
In vitro studies for rheumatoid arthritis
Clinical studies for rheumatoid arthritis
Safety of bee venom therapy
Conclusion
References
Chapter 15 Bee venom: Antitumor activity and its therapeutic applications
Introduction
The physical and chemical attributes of bee venom
Biological active components of bee venom
Enzymes
Phospholipase A2
Phospholipase B
Hyaluronidase
Phosphatase
α -Glucosidase
Peptides
Melittin
Apamin
Mast cell degranulating (MCD) peptide
Adolapin
Tertiapin
Secapin
Cardiopep
General medicinal properties of bee venom
Antitumor activity of bee venom
Alzheimer’s disease
Parkinson’s disease
Antimicrobial properties of bee venom
Conclusion
References
Chapter 16 An overview of risks and benefits of bee products
Introduction
Health benefits of bee products
Honey
Bee pollen
Royal jelly
Propolis
Risks associated with consumption of bee products
Environmental contaminants
Microbial contamination and mycotoxins
Allergic reactions
Chemicals occurring during processing and storage
Adulteration of honey
Poisonous honey
Honey and infant botulism
Conclusion
References
Chapter 17 Future prospects of propolis, bee pollen, royal jelly, and bee venom
Introduction
Challenges in various applications of bee products
Variation in bioactive components of bee products
Propolis
Pollen and bee bread
Royal Jelly
Bee venom
Safe doses and bioavailability of nutrients
Regulations on health claims for bee products
Food applications and dietary supplements with bee products
Outlook for bee products
Conclusion
References
Index
Back Cover
