Dermatological research has experienced a rapid development in the last two decades, however, it has rarely focused on the endocrine functions of the skin. Only a few years ago clinicians and researchers in dermatology started to explore the skin as a target organ for most hormones. In the last years the skin has been recognized as the largest endocrine, paracrine and autocrine organ of the body. It is able to metabolize steroid hormones and to produce derivatives with potentially systemic activity. Disorders of hormone metabolism can either induce direct effects on the skin or indirectly disturb skin homeostasis. Endocrine dermatology is a new and exciting area of skin research. It includes skin diseases due to or associated with endocrine disorders, skin disorders which can be treated with hormones or with compounds with hormone-like activity, and skin disorders which occur as adverse events of hormone treatment or of treatment with compounds exhibiting a hormone-like effect.
Author(s): Christos C. Zouboulis
Edition: 1
Publisher: Not Avail
Year: 2001
Language: English
Pages: 140
Title......Page 1
Preface
......Page 5
Intracrinology and The Skin
......Page 6
Human Skin: An Independent Peripheral
Endocrine Organ
......Page 18
The Hair Follicle: A Paradoxical
Androgen Target Organ
......Page 31
The SAHA Syndrome
......Page 39
Oestrogen Receptor Beta Is Not Present
in the Pilosebaceous Unit of Red Deer
Skin during the Non-Breeding Season
......Page 47
Nuclear Hormone Receptors and Mouse Skin Homeostasis:Implication of PPAR Beta......Page 51
Peroxisome Proliferator-Activated
Receptors and Skin Development
......Page 57
Regulation of Macrophage Gene Expression by the Peroxisome Proliferator-Activated Receptor- Gamma......Page 63
Neuroimmunoregulation of Androgens
in the Adrenal Gland and the Skin
......Page 69
The Role of Melanocortins in Skin
Homeostasis
......Page 75
Prevalence of Endocrine Dysfunction in
HIV-Infected Men
......Page 82
Targeted Somatic Mutagenesis in
Mouse Epidermis
......Page 84
Interaction of Vitamin D and
Retinoid Receptors on Regulation of
Gene Expression
......Page 89
Development of Efficient Transient
Transfection Systems for Introducing
Antisense Oligonucleotides into Human
Epithelial Skin Cells
......Page 94
A Novel Pathway for Hormonally Active
Calcitriol
......Page 100
Successful Treatment of Non-Segmental
Vitiligo: Systemic Therapy with Sex
Hormone-Thyroid Powder Mixture
......Page 104
Liposomal Ursolic Acid (Merotaine)
Increases Ceramides and Collagen in
Human Skin
......Page 106
Association of Insulin Resistance with
Hyperandrogenia in Women
......Page 110
The Molecular Basis of Androgen
Insensitivity
......Page 115
Genetics of Peutz-Jeghers Syndrome,
Carney Complex and Other Familial
Lentiginoses
......Page 122
Author Index Vol. 54, No. 5-6, 2000
......Page 132
Subject Index Vol. 54, No. 5-6, 2000
......Page 133
Author Index Vol. 54, 2000
......Page 134
Subject Index Vol. 54, 2000
......Page 136
Contents Vol. 54, 2000
......Page 138
