SECTION I
BASIC PRINCIPLES
1. Introduction
Bertram G. Katzung, MD, PhD
2. Drug Receptors & Pharmacodynamics
Mark von Zastrow, MD, PhD
3. Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action
Nicholas H. G. Holford, MB, ChB, FRACP
4. Drug Biotransformation
Maria Almira Correia, PhD
5. Development & Regulation of Drugs
Bertram G. Katzung, MD, PhD
SECTION II
AUTONOMIC DRUGS
6. Introduction to Autonomic Pharmacology
Bertram G. Katzung, MD, PhD
7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs
Achilles J. Pappano, PhD
8. Cholinoceptor-Blocking Drugs
Achilles J. Pappano, PhD
9. Adrenoceptor Agonists & Sympathomimetic Drugs
Italo Biaggioni, MD, & David Robertson, MD
10. Adrenoceptor Antagonist Drugs
David Robertson, MD, & Italo Biaggioni, MD
SECTION III
CARDIOVASCULAR-RENAL DRUGS
11. Antihypertensive Agents
Neal L. Benowitz, MD
12. Vasodilators & the Treatment of Angina Pectoris
Bertram G. Katzung, MD, PhD
13. Drugs Used in Heart Failure
Bertram G. Katzung, MD, PhD
14. Agents Used in Cardiac Arrhythmias
Joseph R. Hume, PhD, & Augustus O. Grant, MD, PhD
15. Diuretic Agents
Harlan E. Ives, MD, PhD
SECTION IV
DRUGS WITH IMPORTANT ACTIONS ON SMOOTH MUSCLE
16. Histamine, Serotonin, & the Ergot Alkaloids
Bertram G. Katzung, MD, PhD
17. Vasoactive Peptides
Ian A. Reid, PhD
18. The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds
Emer M. Smyth, PhD, & Garret A. FitzGerald, MD
19. Nitric Oxide
Samie R. Jaffrey, MD, PhD
20. Drugs Used in Asthma
Homer A. Boushey, MD
SECTION V
DRUGS THAT ACT IN THE CENTRAL NERVOUS SYSTEM
21. Introduction to the Pharmacology of CNS Drugs
Roger A. Nicoll, MD
22. Sedative-Hypnotic Drugs
Anthony J. Trevor, PhD, & Walter L. Way, MD
23. The Alcohols
Susan B. Masters, PhD
24. Antiseizure Drugs
Roger J. Porter, MD, & Brian S. Meldrum, MB, PhD
25. General Anesthetics
Helge Eilers, MD, & Spencer Yost, MD
26. Local Anesthetics
Kenneth Drasner, MD
27. Skeletal Muscle Relaxants
Marieke Kruidering-Hall, PhD, & Lundy Campbell, MD
28. Pharmacologic Management of Parkinsonism & Other Movement Disorders
Michael J. Aminoff, MD, DSc, FRCP
29. Antipsychotic Agents & Lithium
Herbert Meltzer, MD, PhD
30. Antidepressant Agents
Charles DeBattista, MD
31. Opioid Analgesics & Antagonists
Mark A. Schumacher, PhD, MD, Allan I. Basbaum, PhD, & Walter L. Way, MD
32. Drugs of Abuse
Christian Lüscher, MD
SECTION VI
DRUGS USED TO TREAT DISEASES OF THE BLOOD, INFLAMMATION, & GOUT
33. Agents Used in Anemias; Hematopoietic Growth Factors
Susan B. Masters, PhD
34. Drugs Used in Disorders of Coagulation
James L. Zehnder, MD
35. Agents Used in Dyslipidemia
Mary J. Malloy, MD, & John P. Kane, MD, PhD
36. Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout
Daniel E. Furst, MD, Robert W. Ulrich, PharmD, & Shraddha Prakash, MD
SECTION VII
ENDOCRINE DRUGS
37. Hypothalamic & Pituitary Hormones
Susan B. Masters, PhD, & Stephen M. Rosenthal, MD
38. Thyroid & Antithyroid Drugs
Betty J. Dong, PharmD, FASHP, FCCP, & Francis S. Greenspan, MD, FACP
39. Adrenocorticosteroids & Adrenocortical Antagonists
George P. Chrousos, MD
40. The Gonadal Hormones & Inhibitors
George P. Chrousos, MD
41. Pancreatic Hormones & Antidiabetic Drugs
Martha S. Nolte Kennedy, MD
42. Agents That Affect Bone Mineral Homeostasis
Daniel D. Bikle, MD, PhD
SECTION VIII
CHEMOTHERAPEUTIC DRUGS
43. Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
44. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
45. Aminoglycosides & Spectinomycin
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
46. Sulfonamides, Trimethoprim, & Quinolones
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
47. Antimycobacterial Drugs
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
48. Antifungal Agents
Don Sheppard, MD, & Harry W. Lampiris, MD
49. Antiviral Agents
Sharon Safrin, MD
50. Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants
Daniel H. Deck, PharmD, & Lisa G. Winston, MD
51. Clinical Use of Antimicrobial Agents
Harry W. Lampiris, MD, & Daniel S. Maddix, PharmD
52. Antiprotozoal Drugs
Philip J. Rosenthal, MD
53. Clinical Pharmacology of the Antihelminthic Drugs
Philip J. Rosenthal, MD
54. Cancer Chemotherapy
Edward Chu, MD, & Alan C. Sartorelli, PhD
55. Immunopharmacology
Douglas F. Lake, PhD, Adrienne D. Briggs, MD, & Emmanuel T. Akporiaye, PhD
SECTION IX
TOXICOLOGY
56. Introduction to Toxicology: Occupational & Environmental
Daniel T. Teitelbaum, MD
57. Heavy Metal Intoxication & Chelators
Michael J. Kosnett, MD, MPH
58. Management of the Poisoned Patient
Kent R. Olson, MD
SECTION X
SPECIAL TOPICS
59. Special Aspects of Perinatal & Pediatric Pharmacology
Gideon Koren, MD
60. Special Aspects of Geriatric Pharmacology
Bertram G. Katzung, MD, PhD
61. Dermatologic Pharmacology
Dirk B. Robertson, MD, & Howard I. Maibach, MD
62. Drugs Used in the Treatment of Gastrointestinal Diseases
Kenneth R. McQuaid, MD
63. Therapeutic & Toxic Potential of Over-the-Counter Agents
Robin L. Corelli, PharmD
64. Dietary Supplements & Herbal Medications
Cathi E. Dennehy, PharmD, & Candy Tsourounis, PharmD
65. Rational Prescribing & Prescription Writing
Paul W. Lofholm, PharmD, & Bertram G. Katzung, MD, PhD
66. Important Drug Interactions & Their Mechanisms
John R. Horn, PharmD, FCCP
Appendix: Vaccines, Immune Globulins, & Other Complex Biologic Products
Harry W. Lampiris, MD, & Daniel S. Maddix, PharmD
