This atlas is designed to be a user-friendly bench-side reference for pathology trainees and general pathologists in handling and interpreting specimens of hepatocellular carcinoma. It provides over 550 high-quality gross and microscopic photos focusing on hepatocellular carcinoma and its mimickers, and demonstrating a full range of various histological variants of hepatocellular carcinoma. Introductory text in each chapter summarises salient clinical associations, pathological features, and molecular alterations of different variants of hepatocellular carcinoma. Differentiation between hepatocellular carcinoma and its mimickers is illustrated through various case studies.
The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.
The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.
Author(s): Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Publisher: Springer
Year: 2022
Language: English
Pages: 204
City: Cham
Preface
Contents
1: Introduction
References
2: Precursor Lesions of Hepatocellular Carcinoma
2.1 Dysplastic Foci
2.1.1 Large Cell Change
2.1.2 Small Cell Change
2.1.3 Iron-Free Foci
2.2 Dysplastic Nodules
2.2.1 Low-Grade Dysplastic Nodule
2.2.2 High-Grade Dysplastic Nodule
2.3 Early Hepatocellular Carcinoma
2.4 Hepatocellular Adenoma
2.4.1 β-Catenin-Activated HCA
References
3: Gross Morphology of Hepatocellular Carcinoma
3.1 Gross Classification
References
4: General Histopathological Features of Hepatocellular Carcinoma
4.1 Architectural Features
4.2 Cytological Features
4.3 Differentiation and Grading
4.4 The Tumour Microenvironment of HCC
4.5 Other Histopathological Features of HCC
4.6 Multiplicity: Intrahepatic Metastasis Versus Multicentric Occurrence
4.7 Prognostic Factors of HCC
References
5: Fibrolamellar Hepatocellular Carcinoma
5.1 Definition
5.2 Synopsis
References
6: Steatohepatitic Hepatocellular Carcinoma
6.1 Definition
6.2 Synopsis
References
7: Clear Cell Hepatocellular Carcinoma
7.1 Definition
7.2 Synopsis
References
8: Macrotrabecular-Massive Hepatocellular Carcinoma
8.1 Definition
8.2 Synopsis
References
9: Scirrhous Hepatocellular Carcinoma
9.1 Definition
9.2 Synopsis
References
10: Lymphocyte-Rich Hepatocellular Carcinoma
10.1 Definition
10.2 Synopsis
References
11: Other Uncommon Histological Variants of Hepatocellular Carcinoma
11.1 Chromophobe Hepatocellular Carcinoma
11.2 Neutrophil-Rich Hepatocellular Carcinoma
11.3 Sarcomatoid Hepatocellular Carcinoma
11.4 Cirrhotomimetic Hepatocellular Carcinoma
11.5 Myxoid Hepatocellular Carcinoma
References
12: Hepatocellular Carcinoma with Cytokeratin 19 Expression
12.1 Definition
12.2 Synopsis
References
13: Combined Hepatocellular-Cholangiocarcinoma
13.1 Definition
13.2 Synopsis
References
14: Post-treatment Changes of Hepatocellular Carcinoma
References
15: Ancillary Tests for Hepatocellular Carcinoma
15.1 Differentiation Between Hepatocellular Carcinoma and Benign Hepatic Lesions
15.2 Determination of Hepatocellular Differentiation
References
16: Tumour Staging for Hepatocellular Carcinoma
16.1 American Joint Committee on Cancer Tumour-Node-Metastasis Staging
16.2 Assessment of Liver Functional Reserve
16.3 Barcelona Clinic Liver Cancer Staging
16.4 Hong Kong Liver Cancer Staging
References
17: Differential Diagnoses of Hepatocellular Carcinoma
17.1 Focal Nodular Hyperplasia
17.2 Hepatocellular Adenoma
17.3 Angiomyolipoma
17.4 Cholangiocarcinoma
17.5 Hepatoblastoma
17.6 Neuroendocrine Neoplasm
17.7 Hepatoid Adenocarcinoma
17.8 Metastatic Renal Cell Carcinoma
17.9 Others
References
