Applied Clinical Pharmacokinetics

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The easiest and most trusted way to learn the clinical application of pharmacokinetics 5 STAR DOODY'S REVIEW! "This is an important reference that teaches clinically relevant pharmacokinetic dosing and therapeutic drug monitoring tools. This second edition includes updated information on dosing immunosuppressants, as well as dosing concepts in pediatric and hemodialysis patients. The book is intended as an instructive tool in pharmacokinetics for healthcare practitioners who wish to learn these concepts and apply them in their clinical practice. The book satisfies its objectives, outlining important pharmacokinetic concepts in an organized and easy to understand fashion. It is also written by a pharmacist with extensive experience in pharmacokinetics and includes clinically pertinent pearls for individual drugs. This second edition succeeds at providing updated information on pharmacokinetic concepts. The book presents information in a manner that allows readers to teach themselves about pharmacokinetic dosing and to update their knowledge about clinically relevant concepts for the medications. These concepts are critical because medications are far too often dosed without individual patient characteristics (weight, age, concomitant medications) in mind. It is important to individualize dosing based on pharmacokinetic methods, to monitor levels, and to adjust subsequent dosing based on peaks, troughs, renal, and hepatic function." -- Doody's The most current, hands-on book in the field, Applied Clinical Pharmacokinetics gives you clear and useful coverage of drug dosing and drug monitoring that no other text can match. It offers the latest standardized techniques and approaches to patient-specific dosing plus new information on more recent pharmacokinetically monitored drugs. Written by a nationally recognized authority in pharmacokinetics, Applied Clinical Pharmacokinetics provides essential information covered in pharmaceutics, pharmacokinetics, therapeutics, and clinical pharmacy courses. It can be also be used as a clinical refresher to brush up on key concepts and procedures. FEATURES NEW! High-yield sections on dosing strategies in all chapters NEW! Up-to-date, ready-to-use information on monitored drugs Valuable coverage of drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure and patients on dialysis All the information that you need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants Tools that simplify learning throughout, such as an introductory chapter on clinical pharmacokinetic and pharmacodynamic concepts, examples of calculations, and problems with answers and explanations at the end of each chapter (20081105)

Author(s): Larry Bauer
Edition: 2
Publisher: McGraw-Hill Medical
Year: 2008

Language: English
Pages: 842

Contents......Page 9
About the Author......Page 11
Preface......Page 13
From Applied Clinical Pharmacokinetics, First Edition......Page 15
Part I: Basic Concepts......Page 17
1 Clinical Pharmacokinetic and Pharmacodynamic Concepts......Page 19
2 Clinical Pharmacokinetic Equations and Calculations......Page 44
3 Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions......Page 68
Part II: Antibiotics......Page 111
4 The Aminoglycoside Antibiotics......Page 113
5 Vancomycin......Page 223
Part III: Cardiovascular Agents......Page 315
6 Digoxin......Page 317
7 Lidocaine......Page 372
8 Procainamide/N-Acetyl Procainamide......Page 414
9 Quinidine......Page 464
Part IV: Anticonvulsants......Page 499
10 Phenytoin......Page 501
11 Carbamazepine......Page 564
12 Valproic Acid......Page 579
13 Phenobarbital/Primidone......Page 615
14 Ethosuximide......Page 642
Part V: Immunosuppressants......Page 663
15 Cyclosporine......Page 665
16 Tacrolimus......Page 698
Part VI: Other Drugs......Page 725
17 Lithium......Page 727
18 Theophylline......Page 761
A......Page 819
B......Page 820
C......Page 821
D......Page 824
E......Page 825
G......Page 826
H......Page 827
J......Page 828
L......Page 829
M......Page 830
N......Page 831
P......Page 832
R......Page 836
S......Page 837
T......Page 838
V......Page 840
Z......Page 842