This book provides insight into established practices and research into apoptosis and senescence. The volume thoroughly examines novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics that still hold mysteries for researchers. In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.
Author(s): David A. Gewirtz, Shawn E. Holt, Steven Grant
Edition: 2nd
Publisher: Humana Press
Year: 2007
Language: English
Pages: 616
Cover......Page 1
Apoptosis,Senescence,and Cancer......Page 2
Cancer Drug Discovery and Development Series......Page 3
Title Page......Page 4
Copyright Page......Page 5
Preface......Page 6
Contents......Page 7
Contributors......Page 10
Introduction and Overview......Page 13
Part I. Apoptosis and Alternative Modes of Cell Death......Page 16
1. The Intrinsic Pathway of Apoptosis......Page 17
2. The Extrinsic Pathway of Apoptosis......Page 45
3. Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival......Page 69
4. Mitotic Catastrophe......Page 87
5. Autophagy and Autophagic Cell Death......Page 106
6. Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis......Page 121
Part II. Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis......Page 135
7. Structure and Function of the Telomere......Page 136
8. Overview of Senescence......Page 156
9. Contributions of Telomerase to Tumorigenesis......Page 169
10. The Role of Telomeres in Genomic Instability......Page 182
Part III. DNA Damage Response, Signaling Pathways, and Tumorigenesis......Page 199
11. Overview of the DNA Damage Checkpoint......Page 200
12. Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer......Page 229
13. Interplay Between H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response......Page 248
14. DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy......Page 269
PartI V. Resistance and Sensitization......Page 283
15. Resistance/Signaling Pathways......Page 284
16. Ceramide and Multidrug Resistance......Page 302
17. Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling......Page 316
18. The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy......Page 338
Part V. Established Cancer Therapies......Page 361
19. Antimetabolites......Page 362
20. Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes......Page 384
21. Perturbations of Cellular Functions by Topoisomerase II Inhibitors......Page 408
22. The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs......Page 424
23. Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents......Page 465
24. Tyrosine Kinase Inhibitors......Page 477
Part VI. Recent and Developing Cancer Therapies......Page 509
25. Monoclonal Antibodies in Lymphomas......Page 510
26. Role of Apoptosis in Anti-Angiogenic Cancer Therapies......Page 536
27. Photodynamic Therapy-Induced Apoptosis......Page 555
28. Modulation of TRAIL Signaling for Cancer Therapy......Page 577
Index......Page 590
