The purpose of this book is to provide information on apoptotic processes involved in major neoplastic diseases and their translations into emerging anti-cancer strategies. The book is divided into 15 chapters, each of which will be focused on one particular cancer (breast, bladder, cervical, colorectal, esophageal, gastric, laryngeal, liver, lung, nasopharyngeal, pancreatic, prostate, thyroid, leukaemia and cutaneous malignant melanoma). A number of established leaders in the field have critically summarized the recent discoveries concerning apoptosis in a particular cancer and its potential for anti-cancer treatment. The book describes how the apoptosis plays a role in the specific carcinogen-induced cellular and molecular changes during the development of the cancer, and critically discusses how the emerging anti-cancer strategy can be built by the utilization of the specific carcinogen-related apoptotic pathway. Therefore, this book will be not only for laboratory-based molecular and cell biologists and biochemists in cancer research but also for clinical oncologists and those working in the pharmaceutical and biotechnological industries.
Author(s): Prasanthi Karna, Lily Yang (auth.), George G. Chen Dr, Paul B.S. Lai Dr (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2009
Language: English
Pages: 384
Tags: Biomedicine general; Apoptosis; Oncology; Cancer Research; Surgical Oncology; Pharmacology/Toxicology
Front Matter....Pages I-XXII
Apoptotic Signaling Pathway and Resistance to Apoptosis in Breast Cancer Stem Cells....Pages 1-23
Anti-Cancer Strategy of Transitional Cell Carcinoma of Bladder Based on Induction of Different Types of Programmed Cell Deaths....Pages 25-50
Apoptosis in Carcinogenesis and Chemoherapy of the Uterine Cervix....Pages 51-73
Apoptosis in Colorectal Tumorigenesis and Chemotherapy....Pages 75-109
Apoptosis in Cutaneous Melanoma....Pages 111-125
Apoptosis in Carcinogenesis and Chemotherapy – Esophageal Cancer....Pages 127-156
Molecular Targets in Gastric Cancer and Apoptosis....Pages 157-192
Apoptosis and the Tumor Microenvironment in Hematologic Malignancies....Pages 193-218
Bcl-2 Family Members in Hepatocellular Carcinoma (HCC) – Mechanisms and Therapeutic Potentials....Pages 219-235
Apoptosis in the Development and Treatment of Laryngeal Cancer: Role of p53, Bcl-2 and Clusterin....Pages 237-249
Cyclooxygenase 2 and its Metabolites: Implications for Lung Cancer Therapy....Pages 251-272
Roles of Negative and Positive Growth Regulators in Nasopharyngeal Carcinoma....Pages 273-294
Cellular Signaling Mechanisms in Pancreatic Apoptosis....Pages 295-325
Strategies to Circumvent Resistance to Apoptosis in Prostate Cancer Cells by Targeted Necrosis....Pages 327-346
Carcinogenesis and Therapeutic Strategies for Thyroid Cancer....Pages 347-374
Back Matter....Pages 375-384
