This significantly revised fourth edition provides a practically orientated guide to interactions associated with antiseizure medications. It describes pharmacokinetic and pharmacodynamic antiseizure medication (ASM) interactions, including details of the magnitude and mechanism of interactions, and also of drug combinations that are not associated with interactions and therefore can be co-prescribed without undue concern.
Presented in alphabetical order and by drug class, drug interactions that occur between ASMs and also between ASMs and non- ASMs are described in three sections: Drug interactions between ASMs; Drug interactions between ASMs and non- ASM Drugs: Interactions affecting ASMs; Drug interactions between ASMs and non ASM Drugs: Interactions affected by ASMs. The latest data on all drug interactions is presented. New agents discussed include cannabidiol, cenobamate, everolimus and fenfluramine,.
Antiseizure Medication Interactions: A Clinical Guide, 4th Edition concisely presents the most recent developments and data available on the topic. Therefore, enabling physicians and allied health professionals to make more rational choices when ASM polytherapy regimens are required. It will be of interest to medical professionals in disciplines including neurology, psychiatry and pediatrics.
Author(s): Philip N. Patsalos
Edition: 4
Publisher: Springer
Year: 2022
Language: English
Pages: 372
City: Cham
Preface
Contents
Part I: Drug Interactions Between ASMs
Introduction
Mechanisms of Drug Interaction
Pharmacodynamic Interactions
Pharmacokinetic Interactions
Interactions Affecting Drug Absorption
Plasma Protein-Binding Displacement Interactions
Interactions at the Renal Level
Metabolic Interactions
CYP Enzymes
Epoxide Hydrolases
Uridine Glucuronyl Transferases
Enzyme Inhibition
Enzyme Induction
Anticipating and Predicting Metabolic Interactions
Factors That Impact on the Relevance of a Metabolic Interaction
Prevention and Management of Adverse ASM Interactions
The Role of Therapeutic Drug Monitoring in the Management of ASM Interactions
References
Acetazolamide
Pharmacokinetic Characteristics
Reference
Brivaracetam
Pharmacokinetic Characteristics
References
Cannabidiol
Pharmacokinetic Characteristics
References
Carbamazepine
Pharmacokinetic Characteristics
References
Cenobamate
Pharmacokinetic Characteristics
References
Clobazam
Pharmacokinetic Characteristics
References
Clonazepam
Pharmacokinetic Characteristics
References
Eslicarbazepine Acetate
Pharmacokinetic Characteristics
References
Ethosuximide
Pharmacokinetic Characteristics
References
Everolimus
Pharmacokinetic Characteristics
References
Felbamate
Pharmacokinetic Characteristics
References
Fenfluramine
Pharmacokinetic Characteristics
References
Gabapentin
Pharmacokinetic Characteristics
References
Lacosamide
Pharmacokinetic Characteristics
References
Lamotrigine
Pharmacokinetic Characteristics
References
Levetiracetam
Pharmacokinetic Characteristics
References
Methsuximide
Pharmacokinetic Characteristics
References
Oxcarbazepine
Pharmacokinetic Characteristics
References
Perampanel
Pharmacokinetic Characteristics
References
Phenobarbital
Pharmacokinetic Characteristics
References
Phenytoin
Pharmacokinetic Characteristics
References
Piracetam
Pharmacokinetic Characteristics
References
Pregabalin
Pharmacokinetic Characteristics
References
Primidone
Pharmacokinetic Characteristics
References
Rufinamide
Pharmacokinetic Characteristics
References
Stiripentol
Pharmacokinetic Characteristics
References
Sulthiame
Pharmacokinetic Characteristics
References
Tiagabine
Pharmacokinetic Characteristics
References
Topiramate
Pharmacokinetic Characteristics
References
Valproic Acid
Pharmacokinetic Characteristics
References
Vigabatrin
Pharmacokinetic Characteristics
References
Zonisamide
Pharmacokinetic Characteristics
References
Part II
Drug Interactions Between ASMs and Non-ASMs: Interactions Affecting ASMs
Acetazolamide
Brivaracetam
References
Cannabidiol
Reference
Carbamazepine
Antiulcer Drugs
Cardiovascular Drugs
Psychotropic Drugs
References
Cenobamate
Reference
Clobazam
References
Clonazepam
References
Eslicarbazepine Acetate
Reference
Ethosuximide
References
Everolimus
Reference
Felbamate
References
Fenfluramine
Gabapentin
References
Lacosamide
References
Lamotrigine
Antimicrobials
Antiulcer Drugs
Psychotropic Drugs
References
Levetiracetam
References
Methsuximide
Oxcarbazepine
References
Perampanel
References
Phenobarbital
References
Phenytoin
Antiulcer Drugs
Cardiovascular Drugs
Psychotropic Drugs
References
Piracetam
Reference
Pregabalin
References
Primidone
References
Rufinamide
Stiripentol
Sulthiame
Reference
Tiagabine
References
Topiramate
References
Valproic Acid
Antiulcer Drugs
Psychoactive Drugs
References
Vigabatrin
Zonisamide
References
Part III
Drug Interactions Between ASMs and Non-ASMs: Interactions Affected by ASMs
Analgesics
References
Antimicrobials
Antibacterials
Antifungal Agents
Antihelmintics
Antituberculous Agents
Antiviral Agents
References
Antineoplastic Agents
References
Antiulcer Drugs
Histamine H2-Receptor Antagonists
Proton-Pump Inhibitors
References
Cardiovascular Drugs
Antianginals
Antiarrhythmics
Antihypertensive Agents
Diuretics
Oral Anticoagulants
Statins
References
Immunosuppressants
References
Neuromuscular Blocking Agents
Atracurium
References
Psychotropic Drugs
Antidepressants
Antipsychotics
Benzodiazepines
References
Steroids
Corticosteroids
References
Miscellanea
References
Index
