Antimicrobial resistance is now a general problem. Many of us have elderly relatives who died from a drug-resistant infection, and some of us have suffered from a resistant urinary infection that likely came from intestinal bacteria following antibiotic consumption. Antimicrobial Resistance in the 21st Century provides a broad introduction to the subject in which the situation with problematic pathogens is detailed, the biology of resistance is described, and gaining approval for new antibiotics is discussed. Some topics are immediately practical, such as watching for resistant pathogen sub-populations in cultures taken from patients; other topics point to future research efforts that may lead to new antimicrobials and ways to stimulate the action of existing ones. Overall, Antimicrobial Resistance in the 21st Century provides an update for physicians, serves as a starting point for graduate students interested in solving the resistance problem, and may serve as a text for a course on resistance. Lay readers familiar with microbiology will gain an appreciation for a medical issue that promises to be one of the most important of our time.
Ignatius Fong, Department of Medicine, University of Toronto
Series Editor – Emerging Infectious Diseases of the 21st Century
David Shlaes, Founder, Anti-Infectives Consulting
Editor – Antimicrobial Agents and Chemotherapy
Karl Drlica, The Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey
Author(s): I. W. Fong, David Shlaes, Karl Drlica
Series: Emerging Infectious Diseases of the 21st Century
Edition: 2nd ed.
Publisher: Springer International Publishing
Year: 2018
Language: English
Pages: XVIII, 775
Tags: Biomedicine; Immunology; Infectious Diseases; Microbiology; Virology; Epidemiology; Public Health
Front Matter ....Pages i-xviii
Introduction: Coordinated Global Action Is Needed to Combat Antimicrobial Resistance (I. W. Fong)....Pages 1-10
Front Matter ....Pages 11-11
Antimicrobial Resistance Among Streptococcus pneumoniae (Catia Cillóniz, Carolina Garcia-Vidal, Adrian Ceccato, Antoni Torres)....Pages 13-38
Emergence of MRSA in the Community (Lacey P. Gleason, David C. Ham, Valerie Albrecht, Isaac See)....Pages 39-69
Resistance of Gram-negative Bacilli to Antimicrobials (Charles R. Dean, Gianfranco De Pascale, Bret Benton)....Pages 71-162
Drug Resistance in Tuberculosis (Neil W. Schluger)....Pages 163-189
Anaerobic Bacteria: Antimicrobial Susceptibility Testing and Resistance Patterns (Audrey N. Schuetz)....Pages 191-215
Clinical Significance and Biologic Basis of HIV Drug Resistance (Rodger D. MacArthur)....Pages 217-232
Resistance of Herpesviruses to Antiviral Agents (William L. Drew, Jocelyne Piret, Guy Boivin)....Pages 233-267
Heteroresistance: A Harbinger of Future Resistance (Karl Drlica, Bo Shopsin, Xilin Zhao)....Pages 269-296
Front Matter ....Pages 297-297
Epidemiology of Bacterial Resistance (Patricia A. Bradford)....Pages 299-339
Transmissible Antibiotic Resistance (George A. Jacoby)....Pages 341-381
Antibiotics and Resistance in the Environment (Marilyn C. Roberts)....Pages 383-407
Phenotypic Tolerance and Bacterial Persistence (Carl Nathan)....Pages 409-429
Staphylococcus aureus Adaptation During Infection (Bo Shopsin, Richard Copin)....Pages 431-459
Bacterial Signal Transduction Systems in Antimicrobial Resistance (Andrew T. Ulijasz, Sarah C. Feid, David G. Glanville)....Pages 461-505
Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance (Elizabeth G. Gibson, Rachel E. Ashley, Robert J. Kerns, Neil Osheroff)....Pages 507-529
Front Matter ....Pages 531-531
Natural Products in Antibiotic Discovery (Fern R. McSorley, Jarrod W. Johnson, Gerard D. Wright)....Pages 533-562
The New Versus Old Target Debate for Drug Discovery (Alice L. Erwin)....Pages 563-592
Non-quinolone Topoisomerase Inhibitors (Anthony Maxwell, Natassja G. Bush, Thomas Germe, Shannon J. McKie)....Pages 593-618
Antimicrobial-Mediated Bacterial Suicide (Yuzhi Hong, Karl Drlica, Xilin Zhao)....Pages 619-642
PK/PD-Based Prediction of “Anti-Mutant” Antibiotic Exposures Using In Vitro Dynamic Models (Alexander A. Firsov, Yury A. Portnoy, Stephen H. Zinner)....Pages 643-666
Front Matter ....Pages 667-667
The Role of Pharmacometrics in the Development of Antimicrobial Agents (Justin C. Bader, Elizabeth A. Lakota, Brian VanScoy, Sujata M. Bhavnani, Paul G. Ambrose)....Pages 669-705
New Regulatory Pathways for Antibacterial Drugs (David Shlaes)....Pages 707-719
Economic Incentives for Antibacterial Drug Development: Alternative Market Structures to Promote Innovation (Marina L. Kozak, Joseph C. Larsen)....Pages 721-753
Back Matter ....Pages 755-775
