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Anthracycline Chemistry and Biology I: Biological Occurence and Biosynthesis, Synthesis and Chemistry

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table of contents

Author(s): Hartmut Laatsch, Serge Fotso (auth.), Karsten Krohn (eds.)
Series: Topics in Current Chemistry 282
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2008

Language: English
Pages: 324
City: Berlin
Tags: Organic Chemistry; Medicinal Chemistry; Biochemistry, general

Front Matter....Pages I-XIV
Front Matter....Pages 1-2
Naturally Occurring Anthracyclines....Pages 3-74
Biosynthetic Anthracycline Variants....Pages 75-99
Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms....Pages 101-140
Front Matter....Pages 141-142
Synthesis of Enantiomerically Pure Anthracyclinones....Pages 143-186
Combinatorial Synthesis of Linearly Condensed Polycyclic Compounds, Including Anthracyclinones, Through Tandem Diels–Alder Additions....Pages 187-214
Fluorinated Anthracyclines....Pages 215-248
Synthesis of the Sugar Moieties....Pages 249-284
Nonnatural Glycosyl Anthraquinones as DNA Binding and Photocleaving Agents....Pages 285-298
Syntheses of Anthracyclines and Fredericamycin A via Strong Base-Induced Cycloaddition Reaction of Homophthalic Anhydrides....Pages 299-319
Back Matter....Pages 321-324