The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. * Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to* Includes contributions by expert movement disorder clinicians and top-level researchers in the field* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
Author(s): Mark LeDoux (Editor)
Publisher: Academic Press
Year: 2005
Language: English
Pages: 821
Tags: Медицинские дисциплины;Неврология и нейрохирургия;
Preface......Page 10
List of Contributors......Page 12
A1: Classification and Clinical Features of Movement Disorders......Page 16
A2: Animal Models and the Science of Movement Disorders......Page 28
A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders......Page 48
A4: Genetics of Spontaneous Mutations in Mice......Page 60
A5: Assessment of Movement Disorders in Rodents......Page 70
A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals......Page 88
A7: Behavior in Drosophila : Analysis and Control......Page 116
A8: Use of C. elegans to Model Human Movement Disorders......Page 126
B1: The Phenotypic Spectrum of Parkinson Disease......Page 142
B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates......Page 154
B3: From Man to Mouse: The MPTP Model of Parkinson Disease......Page 164
B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease......Page 176
B5: Drosophila Models of Parkinson Disease......Page 188
B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease......Page 198
B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease......Page 208
B8: Motor Complications in Primate Models of Parkinson Disease......Page 224
B9: C. elegans Models of Parkinson Disease......Page 234
C1: Clinical Features and Classification of the Human Dystonias......Page 242
C2: The Genetically Dystonic Rat......Page 256
C3: Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm......Page 268
C4: Mouse Models of Dystonia......Page 280
C5: The Owl Monkey Model of Focal Dystonia......Page 294
C6: DYT1 Transgenic Mouse......Page 302
C7: The hph-1 Mouse......Page 308
D1: Clinical and Pathological Characteristics of Huntington Disease......Page 314
D2: Transgenic Rodent Models of Huntington Disease......Page 324
D3: Knock-in and Knock-out Models of Huntington Disease......Page 332
D4: Drosophila Models of Huntington Disease......Page 344
E1: Neurophysiologic Characterization of Tremor......Page 350
E2: Essential Tremor......Page 362
E3: Harmaline Tremor......Page 376
E4: GABA A Receptor a1 Subunit Knockout Mice: A Novel Model of Essential Tremor......Page 384
E5: Production and Physiological Study of Holmes Tremor in Monkeys......Page 392
E6: The Campus Syndrome in Pietrain Pigs......Page 408
F1: Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus......Page 412
F2: Post-Hypoxic Myoclonus in Rodents......Page 430
F3: Baboon Model of Myoclonus......Page 438
G1: Tourette Syndrome......Page 446
G2: Animal Models of Tourette Syndrome......Page 456
H1: Paroxysmal Dyskinesias in Humans......Page 464
H2: The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia......Page 474
H3: Mouse Models of Hyperekplexia......Page 482
H4: Bovine Hyperekplexia......Page 494
H5: Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways......Page 502
I1: Progressive Supranuclear Palsy and Corticobasal Degeneration......Page 520
I2: Genetic Susceptibility and Animal Modeling of PSP......Page 530
I3: Rodent Models of Tauopathies......Page 544
J1: Clinical Spectrum and Pathological Features of Multiple System Atrophy......Page 556
J2: Double-Lesion Animal Models of Multiple System Atrophy......Page 586
J3: A Mouse Model for Multiple System Atrophy......Page 600
K1: Clinical and Pathological Features of Hereditary Ataxias......Page 610
K2: Acquired Ataxias......Page 628
K3: Animal Models of Spinocerebellar Ataxia Type 1 (SCA1)......Page 638
K4: Spinocerebellar Ataxia Type 2 (SCA2)......Page 646
K5: SCA7 Mouse Models......Page 652
K6: Animal Models of Friedreich Ataxia......Page 664
K7: Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders......Page 672
L1: Spasticity......Page 694
L2: Hereditary Spastic Paraplegia: Clinical Features and Animal Models......Page 702
L3: The Spastic Rat with Sacral Spinal Cord Injury......Page 706
L4: Rat Spinal Cord Contusion Model of Spasticity......Page 714
M1: Drug-Induced Movement Disorders......Page 728
M2: Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates......Page 740
M3: Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents......Page 750
M4: Animal Models of Drug-Induced Akathisia......Page 760
N1: Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement......Page 770
Index......Page 774
