Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies.
This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials on therapeutic compounds are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in research and treatment in this exciting field.
Author(s): Rüdiger Liersch, Wolfgang E. Berdel, Torsten Kessler (auth.), Rüdiger Liersch, Wolfgang E. Berdel, Torsten Kessler (eds.)
Series: Recent Results in Cancer Research 180
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2010
Language: English
Pages: 231
Tags: Oncology; Hematology; Cancer Research
Front Matter....Pages i-xiv
Introduction....Pages 1-1
Angiopoietins....Pages 3-13
HIF-1α and Cancer Therapy....Pages 15-34
Chemokines....Pages 35-50
Angiogenesis Inhibition in Cancer Therapy....Pages 51-81
Vascular Integrins: Therapeutic and Imaging Targets of Tumor Angiogenesis....Pages 83-101
PDGF and Vessel Maturation....Pages 103-114
Lymphangiogenesis in Cancer: Current Perspectives....Pages 115-135
Compounds in Clinical Phase III and Beyond....Pages 137-163
Metronomic Chemotherapy: Principles and Lessons Learned from Applications in the Treatment of Metastatic Prostate Cancer....Pages 165-183
Targeting Inflammatory Cells to Improve Anti-VEGF Therapies in Oncology....Pages 185-200
Antibody-Based Vascular Tumor Targeting....Pages 201-216
Caveolae and Cancer....Pages 217-231
