Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as:
- Uncertainty in clinical chemistry measurements
- Metal toxicology in clinical, forensic, and chemical pathology
- Role of analytical chemistry in the safety of drug therapy
- Atomic spectrometric techniques for the analysis of clinical samples
- Biosensors for drug analysis
- Use of X-ray techniques in medical research
Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth.
Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.
Content:Chapter 1 Good Clinical Practice Principles: Legal Background and Applicability (pages 1–27): Umberto Filibeck, Angela Del Vecchio and Fabrizio Galliccia
Chapter 2 Clinical Chemistry and the Quest for Quality (pages 29–58): Sergio Caroli
Chapter 3 Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables (pages 59–96): Marit Sverresdotter Sylte, Tore Wentzel?Larsen and Bjorn J. Bolann
Chapter 4 The Role and Significance of Reference Values in the Identification and Evaluation of Trace Elements from Diet (pages 97–125): Pietro Apostoli and Maria Cristina Ricossa
Chapter 5 Sample Collection, Storage, and Pretreatment in Clinical Chemistry (pages 127–137): Andrew Taylor
Chapter 6 Metal Toxicology in Clinical, Forensic, and Chemical Pathology (pages 139–156): Jose A. Centeno, Todor I. Todorov, Gijsbert B. van der Voet and Florabel G. Mullick
Chapter 7 Elemental Speciation in Clinical Sciences (pages 157–177): Douglas M. Templeton
Chapter 8 The Role of Analytical Chemistry in the Safety of Drug Therapy (pages 179–243): Sandor Gorog
Chapter 9 Analytical Techniques and Quality Control of Pharmaceuticals (pages 245–255): Fedele Manna, Francesca Rossi and Rossella Fioravanti
Chapter 10 Detection of Drugs in Biological Fluids for Antidoping Control (pages 257–268): Sabina Strano and Marcello Chiarotti
Chapter 11 The Applicability of Plasma?Based Techniques to Biological Monitoring (pages 269–317): Ilse Steffan and Goran Vujicic
Chapter 12 Atomic Spectrometric Techniques for the Analysis of Clinical Samples (pages 319–366): Pilar Bermejo Barrera, Antonio Moreda Pineiro and Maria del Carmen Barciela Alonso
Chapter 13 Applications of ICP?MS in Human Biomonitoring Studies (pages 367–395): Peter Heitland and Helmut D. Koster
Chapter 14 Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum (pages 397–408): Munehiro Yoshida
Chapter 15 Application of Organometallic Speciation in Clinical Studies (pages 409–453): Bin He, Chungang Yuan, Jing Sun and Guibin Jiang
Chapter 16 Biosensors for Drug Analysis (pages 455–478): Daniela Deriu and Franco Mazzei
Chapter 17 Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA?ICP?MS) (pages 479–505): Sabine Becker and Susanne Becker
Chapter 18 Applications of LC?MS/MS in Clinical Laboratory Diagnostics (pages 507–534): Uta Ceglarek, Georg Martin Fiedler and Joachim Thiery
Chapter 19 Metabolomics Using UPLC/HPLC?Tandem Mass Spectrometry in Diagnosis and Research of Inherited Metabolic Diseases (pages 535–553): Willem Kulik and Andre B. P. van Kuilenburg
Chapter 20 Biomarkers of Oxidative Stress in Plasma and Urine (pages 555–594): Papasani V. Subbaiah
Chapter 21 The Use of X?Ray Techniques in Medical Research (pages 595–623): Imre Szaloki, Gyula Zaray and Norbert Szoboszlai
Chapter 22 A New Tool Based on the Use of Stable Isotopes and Isotope Pattern Deconvolution (IPD)?ICP?MS for Nutritional and Clinical Studies (pages 625–649): Hector Gonzalez Iglesias, Maria Luisa Fernandez?Sanchez and Alfredo Sanz?Medel
Chapter 23 Breath Analysis: Analytical Methodologies and Clinical Applications (pages 651–689): Alessio Ceccarini, Fabio Di Francesco, Roger Fuoco, Silvia Ghimenti, Massimo Onor, Sara Tabucchi and Maria Giovanna Trivella
Chapter 24 Proteo?Metabolomic Strategies in the Future of Drug Development (pages 691–774): Uwe Christians, Volker Schmitz, Jost Klawitter and Jelena Klawitter
Chapter 25 Basics in Laboratory Medicine: Past, Present, and Future (pages 775–785): Lorand A. Debreczeni, Anna Kovacsay and Sandor Nagy