Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology.
In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.
Author(s): Gang Zheng, Yaning Yang, Xiaofeng Zhu, Robert C. Elston (auth.)
Series: Statistics for Biology and Health
Edition: 1
Publisher: Springer-Verlag New York
Year: 2012
Language: English
Pages: 414
Tags: Statistics for Life Sciences, Medicine, Health Sciences; Statistics, general
Front Matter....Pages I-XXII
Front Matter....Pages 1-1
Introduction to Probability Theory and Statistics....Pages 3-31
Introduction to Genetic Epidemiology....Pages 33-58
Front Matter....Pages 59-59
Single-Marker Analysis for Unmatched Case-Control Data....Pages 61-93
Single-Marker Analysis for Matched Case-Control Data....Pages 95-120
Bayes Factors for Case-Control Association Studies....Pages 121-150
Robust Procedures....Pages 151-206
Front Matter....Pages 207-207
Haplotype Analysis for Case-Control Data....Pages 209-233
Gene-Gene Interactions....Pages 235-256
Front Matter....Pages 257-257
Population Structure....Pages 259-286
Gene-Environment Interactions....Pages 287-308
Power and Sample Size Calculations....Pages 309-333
Front Matter....Pages 335-335
Genome-Wide Association Studies....Pages 337-349
Front Matter....Pages 351-351
Analysis of Family Data....Pages 353-387
Back Matter....Pages 389-414
