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Analysis and purification methods in combinatorial chemistry

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Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."

To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:

  • Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
  • High-throughput analytical methods used to analyze the quality of libraries
  • High-throughput purification techniques
  • Analytical methods applied in post-synthesis and post-purification stages

Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.

This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

Author(s): Bing Yan
Series: Chemical analysis 163
Edition: 1
Publisher: Wiley-Interscience
Year: 2004

Language: English
Pages: 481
City: Hoboken, N.J

Analysis and Puri.cation Methods in Combinatorial Chemistry......Page 4
Copyright......Page 5
CONTENTS......Page 6
PREFACE......Page 10
CONTRIBUTORS......Page 12
PART I ANALYSIS FOR FEASIBILITY AND
OPTIMIZATION OF LIBRARY SYNTHESIS......Page 16
CHAPTER 1 QUANTITATIVE ANALYSIS IN
ORGANIC SYNTHESIS WITH NMR
SPECTROSCOPY Laura H. Lucas and Cynthia K. Larive......Page 18
CHAPTER 2 19F GEL-PHASE NMR
SPECTROSCOPY FOR REACTION
MONITORING AND QUANTIFICATION
OF RESIN LOADING Joseph M. Salvino......Page 52
CHAPTER 3 THE APPLICATION OF SINGLE-BEAD
FTIR AND COLOR TEST FOR REACTION
MONITORING AND BUILDING BLOCK
VALIDATION IN COMBINATORIAL
LIBRARY SYNTHESIS Jason J. Cournoyer, Clinton A. Krueger, Janice V.Wade,
and Bing Yan......Page 68
CHAPTER 4 HR-MAS NMR ANALYSIS OF
COMPOUNDS ATTACHED TO
POLYMER SUPPORTS Meritxell Guinó and Yolanda R. de Miguel......Page 86
CHAPTER 5 MULTIVARIATE TOOLS FOR REAL-TIME
MONITORING AND OPTIMIZATION OF
COMBINATORIAL MATERIALS AND
PROCESS CONDITIONS Radislav A. Potyrailo, Ronald J. Wroczynski,
John P. Lemmon,William P. Flanagan,
and Oltea P. Siclovan......Page 102
CHAPTER 6 MASS SPECTROMETRY AND SOLUBLE
POLYMERIC SUPPORT Christine Enjalbal, Frederic Lamaty, Jean Martinez,
and Jean-Louis Aubagnac......Page 140
PART II HIGH-THROUGHPUT ANALYSIS FOR LIBRARY
QUALITY CONTROL......Page 152
CHAPTER 7 HIGH-THROUGHPUT NMR TECHNIQUES
FOR COMBINATORIAL CHEMICAL
LIBRARY ANALYSIS Ting Hou and Daniel Raftery......Page 154
CHAPTER 8 MICELLAR ELECTROKINETIC
CHROMATOGRAPHY AS A TOOL FOR
COMBINATORIAL CHEMISTRY ANALYSIS:
THEORY AND APPLICATIONS Peter J. Simms......Page 190
CHAPTER 9 CHARACTERIZATION OF SPLIT-POOL
ENCODED COMBINATORIAL
LIBRARIES Jing Jim Zhang and William L. Fitch......Page 224
PART III HIGH-THROUGHPUT PURIFICATION TO
IMPROVE LIBRARY QUALITY......Page 268
CHAPTER 10 STRATEGIES AND METHODS FOR
PURIFYING ORGANIC COMPOUNDS
AND COMBINATORIAL LIBRARIES Jiang Zhao, Lu Zhang, and Bing Yan......Page 270
CHAPTER 11 HIGH-THROUGHPUT PURIFICATION:
TRIAGE AND OPTIMIZATION Jill Hochlowski......Page 296
CHAPTER 12 PARALLEL HPLC IN HIGH THROUGHPUT
ANALYSIS AND
PURIFICATION Ralf God and Holger Gumm......Page 322
PART IV ANALYSIS FOR COMPOUND STABILITY AND
DRUGABILITY......Page 336
CHAPTER 13 ORGANIC COMPOUND STABILITY
IN LARGE, DIVERSE PHARMACEUTICAL
SCREENING COLLECTION Kenneth L. Morand and Xueheng Cheng......Page 338
CHAPTER 14 QUARTZ CRYSTAL MICROBALANCE IN
BIOMOLECULAR RECOGNITION Ming-Chung Tseng, I-Nan Chang, and Yen-Ho Chu......Page 366
CHAPTER 15 HIGH-THROUGHPUT PHYSICOCHEMICA L
PROFILING: POTENTIAL AND
LIMITATIONS Bernard Faller......Page 384
CHAPTER 16 SOLUBILITY IN THE DESIGN OF
COMBINATORIAL LIBRARIES Christopher Lipinski......Page 422
CHAPTER 17 HIGH-THROUGHPUT DETERMINATION
OF LOGDVALUES BY LC/MS METHOD Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt Jr.,
and James J. Bao......Page 450
INDEX......Page 472
CHEMICAL ANALYSIS......Page 476