An Epidemiological Update on COVID-19 brings recent findings about the pandemic to the forefront. The reference is a compilation of eleven chapters contributed by expert scholars in epidemiology and medicine that cover topics of interest to anyone interested in COVID-19 monitoring and response measures. The topics also indicate some clinical areas of interest to COVID-19 researchers that have received attention due to the pandemic. It covers basic knowledge about respiratory conditions associated with SARS-CoV-2 infection and COVID-19 epidemiology. These topics are complemented with chapters detailing the symptoms and biochemical mechanisms of novel coronavirus infections intended for readers with an advanced level of understanding of life sciences and medicine. Special topics such as the immune response to Sars-CoV-2, and, recombinant drugs for COVID-19, are also covered in this book. Each chapter is organized in a reader-friendly format and includes a list of references.
Author(s): Manikandan Dhayalan, S. U. Mohammed Riyaz, S. Parveen
Publisher: Bentham Science Publishers
Year: 2022
Language: English
Pages: 125
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
Dedication
List of Contributors
Acute Respiratory Distress Syndrome (ARDS)
V. Shyamala1,*, R. Harini2, D. Manikandan3 and S.U. Mohammed Riyaz4
INTRODUCTION
PATHOPHYSIOLOGY
CAUSES OF ARDS
EPIDEMIOLOGY
RISK FACTORS
SYMPTOMS OF ARDS
DIAGNOSIS OF ARDS
TREATMENT OF ARDS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
COVID – 19 Pandemic
Shabeer Ahmed N.1,* and Ashar Waheed. M. P.1
INTRODUCTION TO CORONAVIRUS
THE EMERGENCE OF THE CORONAVIRUS
STRUCTURE OF THE CORONAVIRUS
RESPIRATORY VIRUS INFECTION IN HUMANS AND ITS DETECTION
GENOMIC VARIATIONS IN SARS-COV-2
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Best and Worst Epidemiological Scenarios Of COVID-19
Mohamed Tariq N.P.M.1, D. Manikandan2 and S.U. Mohammed Riyaz1,*
INTRODUCTION
THE SPREAD OF THE VIRUS
Overview
WORST
Best Memories
Worst Memories
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Neuropathological Features of Covid-19
G. Kalaiarasi1,4,*, E. Saravanakumar2, B. Keerthana3 and B. Prabha1
INTRODUCTION
Animal Models of Neurotropic Coronavirus Infections
Mechanism of CNS Invasion
POTENTIAL ROUTES AND MECHANISMS OF CNS INVOLVEMENT IN COVID-19
Principle Mechanisms of SARS-CoV-2 CNS Infection
Neuropathology of SARS-CoV-2
Hypoxic Brain Injury
Immune-mediated Injury
Neurological Manifestations and Complications of COVID-19
CNS Manifestation Associated with COVID-19
PNS Manifestations Associated with COVID-19
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Intermediate Host of CoV and SARS-CoV-2
R. Nishanthi1, S. Malathi2, E.G. Jagan2,3, D. Manikandan4 and S.U.Mohammed Riyaz5,*
ROLE OF INTERMEDIATE HOST- PLACE OF RE-ASSORTMENT
CORONAVIRUS
NATURAL RESERVOIRS OF VIRUS - BATS
MAJOR VIRUS OUTBREAK-BAT AS PREDOMINANT INTERMEDIATE HOST
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Lung Recruitability in COVID-19
K. Priadharsini1, D. Manikandan2, Sajeer Koolath4, G. Rajasekhar Reddy5 and S.U. Mohammed Riyaz3,*
INTRODUCTION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
A Randomized Trial of Hydroxychloroquine as Post-exposure Prophylaxis for COVID-19
Kailasam Saravana Mani1,2,*
INTRODUCTION
Endocytic Pathway for SARS-CoV2 Entry
Coronavirus Structural Proteins
Hydroxychloroquine as SARS-CoV2 Inhibitors
Clinical Trials with Hydroxychloroquine (HCQ) for COVID-19
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Immunogenicity of SARS CoV-2 Vaccine
B. Prabha1,*, G. Kalaiarasi1,3 and B. Keerthana2
INTRODUCTION
Root of COVID-19
Immunogenicity
Corona Viral Genome Structure
SARS-CoV-2 Virus
Conventional Coronavirus Vaccines
Inactivated Vaccine
Live-attenuated Vaccine
Viral Vector Vaccine
Subunit Vaccine
Nucleic Acid Vaccine
The Obstructions in the Development of SARS-2 Vaccine
The Current Pipeline for SARS-CoV-2 Vaccines
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
SARS-CoV-2 Recombinant of Drug
Pandurangan Ranjani1, Atulbabu Govindaraju2, D. Manikandan3 and S.U.Mohammed Riyaz4,*
INTRODUCTION
Vaccine Development Stages
Pre-clinical Stage
Clinical Trial Phase I
Vaccine Design
Vaccine Platforms
Vaccine Candidates for COVID-19
Vaccine Development in India
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Human To Human Transmission of SARS – CoV-2
K. Priadharsini1, D. Manikandan2, P. Rajesh Babu3 and S.U. Mohammed Riyaz4,*
SPREAD OF CORONAVIRUSES
Asymptomatic and Human To Human Transmission of SARS-CoV-2
Strengths and Limitations
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Immune Response for SARS CoV-2
Sri Ranjani Sakthinathan1, D. Manikandan3, Sajeer Koolath4, G. Rajasekhar Reddy5 and Karthic Kumar Balan2,*
INTRODUCTION
MECHANISM OF IMMUNE SYSTEM IN THE BODY
IMPACT OF COVID-19 ON THE HUMAN BODY
Effect on Coagulation
Pulmonary Effects
Cardiac Effects
Renal Effects
Effect on Brain
Effect on Git
Psychological Effects
PATHOGENESIS OF COVID-19
Asymptomatic Phase
Infection of the Upper Respiratory Tract
Progression of the Infection to Lower Respiratory Tract
Viral Transmission
Clinical Features
CLINICAL SPECTRUM
Immune Response Against Covid-19
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
