Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Key Features * Summarizes current state of amiloride-sensitive sodium channel field * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal regulation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * Provides ideas on sodium channels and disease
Author(s): Dale J. Benos (Eds.)
Series: Current Topics in Membranes 47
Edition: 1
Publisher: Academic Press
Year: 1999
Language: English
Pages: ii-xxi, 3-384
Content:
Series Editors
Page ii
Edited by
Page iii
Copyright page
Page iv
Dedication
Page v
Contributors
Pages xv-xviii
Preface
Pages xix-xxi
Dale J. Benos
Chapter 1 Mapping Structure/Function Relations in αbENaC Original Research Article
Pages 3-24
C.M. Fuller, I.I. Ismailov, B.K. Berdiev, V.Gh. Shlyonsky, D.J. Benos
Chapter 2 Membrane Topology, Subunit Composition, and Stoichiometry of the Epithelial Na+Channel Original Research Article
Pages 25-36
Peter M. Snyder, Chun Cheng, Michael J. Welsh
Chapter 3 Subunit Stoichiometry of Heterooligomeric and Homooligomeric Epithelial Sodium Channels Original Research Article
Pages 37-48
Farhad Kosari, Bakhram K. Berdiev, Jinqing Li, Shaohu Sheng, Iskander Ismailov, Thomas R. Kleyman
Chapter 4 Cell-Specific Expression of ENaC and its Regulation by Aldosterone and Vasopressin in Kidney and Colon Original Research Article
Pages 51-63
N. Farman, S. Djelidi, M. Brouard, B. Escoubet, M. Blot-Chabaud, J.P. Bonvalet
Chapter 5 Regulation of ENaC by Interacting Proteins and by Ubiquitination Original Research Article
Pages 65-86
Olivier Staub, Pamela Plant, Toru Ishikawa, Laurent Schild, Daniela Rotin
Chapter 6 Role of G Proteins in the Regulation of Apical Membrane Sodium Permeability by Aldosterone in Epithelia Original Research Article
Pages 87-94
Sarah Sariban-Sohraby
Chapter 7 The Role of Posttranslational Modifications of Proteins in the Cellular Mechanism of Action of Aldosterone Original Research Article
Pages 95-107
J.P. Johnson, J.-M. Wang, R.S. Edinger
Chapter 8 Regulation of Amiloride-Sensitive Na+ Channels in the Renal Collecting Duct Original Research Article
Pages 109-131
James A. Schafer, Li Li, Duo Sun, Ryan G. Morris, Teresa W. Wilborn
Chapter 9 cAMP-Mediated Regulation of Amiloride-Sensitive Sodium Channels: Channel Activation or Channel Recruitment? Original Research Article
Pages 133-154
Peter R. Smith
Chapter 10 Human Lymphocyte Ionic Conductance Original Research Article
Pages 155-176
James K. Bubien
Chapter 11 Regulatory Aspects of Apx, a Novel Na+ Channel with Connections to the Cytoskeleton Original Research Article
Pages 177-194
Horacio F. Cantiello
Chapter 12 Species-Specific Variations in ENaC Expression and Localization in Mammalian Respiratory Epithelium Original Research Article
Pages 197-200,200A,200B,200C,200D,200E,200F,200G,200H,200I,200J,200K,200L,200M,200N,200O,200P,201-217
Colleen R. Talbot
Chapter 13 Inhibition of Vectorial Na+ Transport across Alveolar Epithelial Cells by Nitrogen-Oxygen Reactive Species Original Research Article
Pages 219-238
Sadis Matalon, Ahmed Lazrak, Michael D. DuVall
Chapter 14 Induction of Epithelial Sodium Channel (ENaC) Expression and Sodium Transport in Distal Lung Epithelia by Oxygen Original Research Article
Pages 239-254
Bijan Rafli, A. Keith Tanswell, Olli Pitkänen, Hugh O'Brodovich
Chapter 15 Catecholamine Regulation of Amiloride-Sensitive Na+ Transport in the Fetal Rat Alveolar Epithelium Original Research Article
Pages 255-278
Yoshinori Marunaka, Naomi Niisato
Chapter 16 Cyclic Nucleotide-Gated Cation Channels Contribute to Sodium Absorption in Lung: Role of Nonselective Cation Channels Original Research Article
Pages 279-294
Sandra Guggino
Chapter 17 C. elegans Members of the DEG/ENaC Channel Superfamily: Form and Function Original Research Article
Pages 297-314
Heather A. Thieringer, Sukhvinder Sahota, Itzhak Mano, Monica Driscoll
Chapter 18 Amiloride-Sensitive Sodium Channels in Taste Original Research Article
Pages 315-336
Bernd Lindemann, Timothy A. Gilbertson, Sue C. Kinnamon
Chapter 19 The Involvement of Amiloride-Sensitive Na+ Channels in Human Genetic Hypertension: Liddle's Syndrome Original Research Article
Pages 339-349
Dale J. Benos
Chapter 20 Epithelial Sodium Channels in Cystic Fibrosis Original Research Article
Pages 351-380
Bakhrom K. Berdiev, Iskander I. Ismailov
Index
Pages 381-384
