AID for Immunoglobulin Diversity

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Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Author(s): Frederick W. Alt and Tasuku Honjo (Eds.)
Series: Advances in Immunology 94
Edition: 1
Publisher: Academic Press
Year: 2007

Language: English
Pages: 1-321
Tags: Медицинские дисциплины;Иммунология и аллергология;Advances in immunology;

Content:
Discovery of Activation‐Induced Cytidine Deaminase, the Engraver of Antibody Memory Review Article
Pages 1-36
Masamichi Muramatsu, Hitoshi Nagaoka, Reiko Shinkura, Nasim A. Begum, Tasuku Honjo

DNA Deamination in Immunity: AID in the Context of Its APOBEC Relatives Review Article
Pages 37-73
Silvestro G. Conticello, Marc‐Andre Langlois, Zizhen Yang, Michael S. Neuberger

The Role of Activation‐Induced Deaminase in Antibody Diversification and Chromosome Translocations Review Article
Pages 75-107
Almudena Ramiro, Bernardo Reina San‐Martin, Kevin McBride, Mila Jankovic, Vasco Barreto, André Nussenzweig, Michel C. Nussenzweig

Targeting of AID‐Mediated Sequence Diversification by cis‐Acting Determinants Review Article
Pages 109-125
Shu Yuan Yang, David G. Schatz

AID‐Initiated Purposeful Mutations in Immunoglobulin Genes Review Article
Pages 127-155
Myron F. Goodman, Matthew D. Scharff, Floyd E. Romesberg

Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism Review Article
Pages 157-214
Jayanta Chaudhuri, Uttiya Basu, Ali Zarrin, Catherine Yan, Sonia Franco, Thomas Perlot, Bao Vuong, Jing Wang, Ryan T. Phan, Abhishek Datta, John Manis, Frederick W. Alt

Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection Review Article
Pages 215-244
Brad R. Rosenberg, F. Nina Papavasiliou

Role of AID in Tumorigenesis Review Article
Pages 245-273
Il‐mi Okazaki, Ai Kotani, Tasuku Honjo

Pathophysiology of B‐Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies Review Article
Pages 275-306
Anne Durandy, Nadine Taubenheim, Sophie Peron, Alain Fischer

Series Editors
Page II

Contents
Pages V-VIII

Contributors to Volume 94
Pages IX-XI

Preface
Pages XIII-XV
Frederick W. Alt, Tasuku Honjo

Index
Pages 307-315

Contents of Recent Volumes
Pages 317-321