Platelet rich plasma therapy uses a patient's own platelets to encourage and accelerate healing in a variety of tissues. With the growing popularity of using platelet rich plasma for aesthetic procedures, the need for a book that ties together all of the current literature in one place has become more pressing. This book fills in that gap as a comprehensive guide that covers history, basic science and clinical utility of platelet rich plasma with its uses in hair restoration, facial rejuvenation, and some wound healing. It includes the latest studies/literature from peer reviewed journals and clinical, anecdotal experience. Chapters provide an extensive look at how to describe the mechanism of action of platelet rich plasma (PRP) in the skin and hair; how to identify the difference between PRP, platelet rich fibrin, and stem cells; and identify the various PRP preparation systems and how to calculate dosing.
Aesthetic Clinician's Guide to Platelet Rich Plasma is written especially for the aesthetic clinician, whether dermatologist or plastic surgeon. This book will find utility across specialties and with it's extensive coverage it is a vital reference.
Author(s): Shilpi Khetarpal
Publisher: Springer
Year: 2021
Language: English
Pages: 141
City: Cham
Preface
Acknowledgment
Contents
Editor and Contributors
Editor
Contributors
History of PRP
1 PRP in Hematology
2 PRP in Orthopedics
3 PRP in Maxillofacial Surgery
4 Dermatologic Applications
5 PRP Subtypes and Definitions
6 Platelet Biology and Growth Factors
7 PRP Collection
8 Conclusion
References
Basic Science of PRP
1 Introduction
2 Mechanism of Action
3 Classification Systems
4 Applications
5 Preparation and Technique
6 Validated Outcomes
7 Getting Started with PRP
8 Discussion
References
Preparation Systems
1 Introduction
2 Overview
3 FDA Regulation
4 Classification Systems
5 Device Selection Criteria
6 Costs
7 Types of FDA-Cleared Systems
8 Preparatory Procedure
8.1 Tubes
8.2 Anticoagulants
8.3 Separator Gels
8.4 Centrifugation
8.5 Platelet Activation
9 Final Product Characterization
9.1 Concentration of Platelets and Growth Factors
9.2 Concentration of Other Cell Lineages
10 Warnings
11 Conclusion
12 Future Directions
References
Microneedling + PRP (for Rejuvenation, Acne Scarring)
1 Introduction
2 Scars
2.1 Acne Scars
2.2 Post-traumatic Scars
3 Striae Distensae
4 Melasma
5 Rejuvenation
6 Side Effects, Adverse Events, and Limitations
7 Conclusion
References
PRP in Combination Therapy for Hair Loss (AGA)
1 Introduction
2 Pathophysiology of AGA
3 Clinical Features of AGA
4 Mechanism of Action of PRP for Treatment of AGA
5 Protocol
6 PRP as an Adjuvant Therapy for Treatment of AGA
7 Clinical Outcomes of PRP Used for Treatment of AGA
8 Efficacy of PRP in Combination with Microneedling
9 Variations in PRP Formulations for Treatment of AGA
References
PRP for Scarring Alopecia
1 Pathogenesis of Scarring Alopecia
2 Classification of Primary Scarring Alopecia
3 Standard Treatments of Primary Scarring Alopecia
4 Potential Benefits of PRP in Primary Scarring Alopecia
5 Clinical Outcomes of PRP in Primary Scarring Alopecia
5.1 Evidence from the Literature
5.2 Anecdotal Evidence
6 Conclusion
References
PRP for Immune Mediated Alopecias (Alopecia Areata, Alopecia Totalis)
1 Introduction
1.1 Overview of Alopecia Areata
1.2 Mechanism of Action of PRP
1.3 Mechanism of Action of Stem Cells
2 Clinical Applications
2.1 Applications of PRP in Alopecia Areata
2.2 Applications of Stem Cells in Alopecia Areata
3 Conclusion
References
Platelet-Rich Fibrin Matrix
1 Introduction
1.1 The Journey of Platelet Concentrates: First to Second Generation
1.2 Dermatologic Indications
2 Wound Healing
2.1 Ongoing Debate
2.1.1 Safety
2.1.2 Not All PRP Is Created Equal
2.1.3 PRP Versus PRFM: Which Is Superior?
3 Conclusion
References
PRP and Hair Transplants
References
Exosomes and Stem Cells
1 Introduction
2 Stem Cells as Treatment for Hair Loss
3 Stem Cell-Conditioned Media as a Treatment for Hair Loss
4 Exosomes as a Treatment for Hair Loss
5 Exosome Controversies
6 Experiences from the Authors
7 Conclusion
References
Index
