Advances in Virus Research, Volume 113 in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Sections cover RNA modifications in viruses and virus infected cells, RNA silencing suppression, Animal models of alphavirus infection, and Enterovirus entry and spread.
Author(s): Margaret Kielian, Thomas C. Mettenleiter, Marilyn J. Roossinck
Series: Advances in Virus Research, 113
Publisher: Academic Press
Year: 2022
Language: English
Pages: 118
City: London
Front Cover
Advances in Virus Research
Copyright
Contents
Contributors
Chapter One: Diversity of viral RNA silencing suppressors and their involvement in virus-specific symptoms
1. Introduction
2. Principles of RNA silencing pathways in plants
2.1. Diversification of RNA silencing suppressors
2.2. Suppression strategies
3. Multilayer strategies of viruses for suppressing RNA silencing at the cellular level
3.1. Geminiviruses: A complete armamentarium of small and large antiviral defense suppressors
3.2. Potyviruses: Multitasking HCPro
3.3. Tombusviruses: Different effects of p19: siRNA-binding ability and beyond
3.4. Cucumoviruses: Further expansion of 2b protein functionality by post-translational modification
4. Concluding remarks
Acknowledgments
References
Chapter Two: Animal models of alphavirus infection and human disease
1. Introduction
2. Alphavirus transmission cycles
3. Human clinical disease
3.1. Arthritogenic alphaviruses
3.1.1. Disease signs and symptoms
3.1.2. Pathology
3.1.3. Virology
3.2. Encephalitic Alphaviruses
3.2.1. Disease signs and symptoms
3.2.2. Pathology
3.2.3. Virology
4. Animal models
4.1. Natural reservoir hosts
4.1.1. Natural reservoir hosts
4.1.2. Rodents
4.1.3. Birds
4.1.4. Horses
4.2. Vectors
5. Animal models of human disease
5.1. Mice
5.1.1. Ross river virus
5.1.2. Barmah forest virus
5.1.3. Mayaro and o´nyong nyong viruses
5.1.4. Eastern equine encephalitis virus
5.1.5. Venezuelan equine encephalitis virus
5.1.6. Western equine encephalitis virus
5.1.7. Sindbis and Semliki Forest viruses
5.2. Other rodents
5.2.1. Hamsters
5.2.2. Guinea pigs
5.2.3. Rats
5.3. Non-human primates
5.3.1. Arthritogenic alphaviruses in non-human primates
5.3.2. Encephalitic alphaviruses in non-human primates
6. Animal models of unique aspects of alphavirus infection
6.1. Transmission studies
6.1.1. Aerosol transmission
6.1.2. Mosquito and mosquito component-based infection models
6.2. Co-infection studies
6.2.1. Plasmodium spp.
6.2.2. Dengue virus
7. Virus strains used in animal models
8. Conclusions
Acknowledgments
References
Chapter Three: Enteroviruses: The role of receptors in viral pathogenesis
1. Introduction
2. Transmission and viral life cycle
3. Enterovirus structure
4. Enteroviruses and their receptors
4.1. Enterovirus A
4.2. Coxsackievirus A and EV71
4.3. Enterovirus B
4.4. Coxsackievirus A9
4.5. Coxsackievirus B
4.6. Echoviruses
4.7. Enterovirus D
4.8. Enterovirus D68
4.9. Enterovirus D70
5. Enterovirus disease modeling
6. Concluding remarks
References
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