The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
Author(s): Nancy H. Ruddle (auth.), David Wallach, Andrew Kovalenko, Marc Feldmann (eds.)
Series: Advances in Experimental Medicine and Biology 691
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 844
Tags: Immunology; Microbiology; Biomedicine general
Front Matter....Pages i-xxxvi
Front Matter....Pages 1-1
Workshop Summary: Roles of the TNF Family in Normal Development and Cancer ....Pages 3-4
TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System....Pages 5-22
The Edar Subfamily in Hair and Exocrine Gland Development....Pages 23-33
High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature....Pages 35-44
Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR....Pages 45-50
Front Matter....Pages 51-51
Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs ....Pages 53-61
TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling....Pages 63-78
New Perspectives in TNF-R1-Induced NF- κ B Signaling....Pages 79-88
Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation....Pages 89-91
Front Matter....Pages 93-93
Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF- κ B Precursor....Pages 95-106
Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activation....Pages 107-114
The Linear Ubiquitin Chain Assembly Complex (LUBAC) Forms Part of the TNF-R1 Signalling Complex and Is Required for Effective TNF-Induced Gene Induction and Prevents TNF-Induced Apoptosis....Pages 115-126
Temporal Control of TNFα Signaling by Miz1....Pages 127-128
Front Matter....Pages 129-129
Large-Scale RNAi Screens to Dissect TNF and NF- κ B Signaling Pathways....Pages 131-139
Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases....Pages 141-150
Understanding Life and Death at CD95....Pages 151-161
Unique Personalities Within the NF- κ B Family: Distinct Functions for p65 and RelB in the Osteoclast....Pages 163-167
Front Matter....Pages 169-169
Workshop Summary: Functions of the TNF Family in Infectious Disease....Pages 171-175
Role of 4-1BBL and TRAF1 in the CD8 T Cell Response to Influenza Virus and HIV....Pages 177-186
Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection....Pages 187-201
Front Matter....Pages 169-169
Poxviral TNFRs: Properties and Role in Viral Pathogenesis....Pages 203-210
Heme Sensitization to TNF-Mediated Programmed Cell Death....Pages 211-219
TNF-α and TNFR in Chagas Disease: From Protective Immunity to Pathogenesis of Chronic Cardiomyopathy....Pages 221-230
Lymphotoxin’s Link to Carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer....Pages 231-249
Front Matter....Pages 251-251
Anti-inflammatory Functions of Caspase-8....Pages 253-260
Endogenous Ligand-Induced Activation of TLR4 in Pre-metastatic Phase Is Both Downstream and Upstream of TNF Signaling....Pages 261-268
Front Matter....Pages 269-269
Introductory Words About TL1A/DR3....Pages 271-274
Introductory Words About TWEAK/Fn14....Pages 275-277
Insights into TL1A and IBD Pathogenesis....Pages 279-288
The Role of TNFRSF25:TNFSF15 in Disease… and Health?....Pages 289-298
Identification of New Candidates as Mucosal Vaccine Adjuvant in TNF Family Cytokines....Pages 299-304
The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse....Pages 305-322
TWEAK and the Kidney: the Dual Role of a Multifunctional Cytokine....Pages 323-335
TWEAK and TNF Regulation of Sclerostin: A Novel Pathway for the Regulation of Bone Remodelling....Pages 337-348
Front Matter....Pages 349-349
Workshop Summary: Control of Lymphocyte Function and Repertoire by the TNF Superfamily....Pages 351-352
The Canonical and Unconventional Ligands of the Herpesvirus Entry Mediator....Pages 353-362
The Lymphotoxin Pathway as a Novel Regulator of Dendritic Cell Function....Pages 363-374
Involvement of the Cytokine Receptor CD137 in Murine Hematopoiesis....Pages 375-382
LTBR-Pathway in Sjogren’s Syndrome: CXCL13 Levels and B-cell-Enriched Ectopic Lymphoid Aggregates in NOD Mouse Lacrimal Glands Are Dependent on LTBR....Pages 383-390
MEK Kinase 1: Kinase Domain Deficiency in Mice Reveals a Role in Orchestrating the Thymus-Dependent Immunity and TNFR Family Signaling....Pages 391-397
Front Matter....Pages 399-399
Introduction to the Session “Mechanisms of Pathological and Therapeutic Effects of the TNF Family”....Pages 401-402
Mechanisms Regulating TNF-Driven Gut and Joint Inflammation....Pages 403-408
Lessons from Anti-TNF Biologics: Infliximab Failure in a TRAPS Family with the T50M Mutation in TNFRSF1A ....Pages 409-419
Modalities of Experimental TNF Blockade In Vivo: Mouse Models....Pages 421-431
Tumor Necrosis Factor-α Signaling via TNFR1/p55 Is Deleterious Whereas TNFR2/p75 Signaling Is Protective in Adult Infarct Myocardium....Pages 433-448
TNF-α Regulation of CD38 Expression in Human Airway Smooth Muscle: Role of MAP Kinases and NF-κB....Pages 449-459
Functional Consequences of Disease-Associated Mutations in TNFR1 Elucidated by Transcriptome Analysis....Pages 461-470
Tumor Necrosis Factor-α and Kidney Function: Experimental Findings in Mice....Pages 471-480
Strategies to Inhibit the Toxicity of Systemic TNF Treatment....Pages 481-484
Front Matter....Pages 485-485
Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family....Pages 487-491
Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis....Pages 493-500
A Proliferation-Inducing Ligand (APRIL): The Development of Antagonistic Agents as Potential Therapeutics and Deciphering the Role of Heparan Sulphate Proteoglycans (HSPGs) in APRIL Signalling....Pages 501-506
Genetic Engineering of Death Ligands for Improvement of Therapeutic Activity....Pages 507-519
Computational Design of TNF Ligand-Based Protein Therapeutics....Pages 521-534
Front Matter....Pages 535-535
Workshop Summary: Roles of the TNF Family in Neuronal Development, Function and Pathology....Pages 537-538
TNF: A Key Neuroinflammatory Mediator of Neurotoxicity and Neurodegeneration in Models of Parkinson’s Disease....Pages 539-540
The Contribution of TNFα to Synaptic Plasticity and Nervous System Function....Pages 541-557
Intracellular and Intercellular Cross Talk Between NGF and TNF....Pages 559-565
TNFR2 – Target for Therapeutics Against Neurodegenerative Diseases?....Pages 567-573
A Role for Neuronal NF-κB in Suppressing Neuroinflammation and Promoting Neuroprotection in the CNS....Pages 575-581
Front Matter....Pages 583-583
Workshop Summary: Cell Death Mechanisms Controlled by the TNF Family....Pages 585-588
A RNA Interference Screen Identifies RIP3 as an Essential Inducer of TNF-Induced Programmed Necrosis....Pages 589-593
The Extracellular Matrix Protein CCN1 Dictates TNFα and FasL Cytotoxicity In Vivo....Pages 595-603
Compartmentalization of TNF-Receptor 1 Signaling: TNF-R1-Associated Caspase-8 Mediates Activation of Acid Sphingomyelinase in Late Endosomes....Pages 605-616
TNF/TNF Receptor 1-Mediated Apoptosis in Hepatocytes....Pages 617-624
Regulation of Cell Death by c-FLIP Phosphorylation....Pages 625-630
Back Matter....Pages 631-844
