Advances in the Neuroscience of Addiction (Frontiers in Neuroscience)

Cover Page......Page 1
Frontiers In Neuroscience......Page 3
Title: Advances In The Neuroscience Of Addiction......Page 7
ISBN 9780849373916......Page 8
Contents......Page 9
Series Preface......Page 10
The Editors......Page 11
Contributors......Page 13
1.1.1 The Neurobehavioral Basis of Drug Seeking and Relapse......Page 15
1.1.2 Modeling Relapse in Animals......Page 17
1.1.3 Significance of Considering Dependence History......Page 19
1.2 Modeling the Incentive Effects of Drug Cues in Dependent Subjects......Page 22
1.2.2 Significance of Stimuli Conditioned to Negative......Page 23
1.3.1 Interactive Effects of Drug Cues and Stress......Page 27
1.4 Concluding Remarks......Page 29
References......Page 34
Contents......Page 41
2.2 Basic Method......Page 43
2.3.1 Importance of Electrophysiological Investigationsfor Identifying Causes and Treatment s of Addiction......Page 47
2.3.3 Studies of Acute and Chronic Drug Effects: Advant ages andDisadvant ages of Different Electrophysiological Approaches......Page 48
2.4.1.1 Acute Drug Effects......Page 51
2.4.1.2 Chronic Drug Effects......Page 52
2.4.2 Testing Drug Addiction Hypotheses......Page 53
2.5.2.1 Description of the Firing Patterns......Page 56
2.5.2.2 Determinants of the Firing Patterns......Page 58
2.5.3.2 Determinants of the Firing Patterns......Page 63
2.5.4.1 Description of the Firing Patterns......Page 67
2.5.4.2 Determinants of the Firing Pattern......Page 68
2.5.5 Firing Patterns during Cocaine Taking: Section Summary, Novel Find ings, and Research Opportunities......Page 70
2.6.2.1 NAc Firing at the Onset of an FR1 Cocaine Self-Administration Session......Page 71
2.6.2.2 NAc Firing Patterns during Cue-Evoked and Nonreinforced Drug-Directed Behavior......Page 73
2.6.2.3 Drug-Directed Behavior Maintained by Presentation of a Conditioned Reinforcer......Page 74
2.6.3 Firing Patterns during Cocaine Seeking: Summary, Novel Findings, and Research Opportunities......Page 75
2.7.1 Background and Overview......Page 77
2.7.2 Session-Long Decreases but Not Session-Long Increases in Firing Covary with Drug Level......Page 79
2.7.3 Evidence That the Inhibitory Effects of Self-Administered Cocaine Are Activity Dependent......Page 82
2.8.1 Slice and Anesthetized Animal Recording Studies......Page 85
2.8.2 Recordings in Behaving Animals......Page 86
2.8.3 Effects of Extended Abstinence......Page 89
2.8.4 Chronic Drug-Induced Neuroadaptations: Summary, Novel Findings, and Research Opportunities......Page 90
2.9.2 Advances in Behavioral Assays......Page 93
2.9.3 Getting at Mechanism: Combining Chronic Recording with Other Techniques......Page 94
2.10 Conclusions......Page 95
References......Page 97
Microwire Implant......Page 107
Postoperative Care......Page 108
Tethering System......Page 109
Recording Equipment......Page 110
Histology......Page 111
3.1 Introduction and Scope......Page 113
3.2 Principles of Voltammetry and Microdialysis......Page 114
3.2.1 General Principles......Page 115
3.2.2 Historical Perspective......Page 117
3.3.1 Technical Aspects......Page 119
3.3.2 General Comparisons......Page 122
3.3.3 Applications......Page 125
3.4 Recent Advances in Microdialysis......Page 129
3.4.1 Capillary Liquid Chromatography......Page 131
3.4.3 Laser-Induced Fluorescence......Page 132
3.4.4 Mass Spectrometry......Page 133
3.5 Recent Advances in Biosensors......Page 135
3.6 Concluding Remarks......Page 138
References......Page 140
4.1 Introduction and Scope......Page 151
4.2 Methodical Approaches to Study Neuronal Systems Relevant for Alcohol Addiction......Page 152
4.3 Neurotransmitter Systems Implicated in Craving for Alcohol and Other Drugs of Abuse......Page 154
4.4 Behavioral Design of Studies that Measure Neuronal Systems Activated by Alcohol-Associated Cues......Page 158
4.4.1 Important Behavioral Parameters in Imaging Studies......Page 159
4.4.2 Cue-Induced Brain Activation and the Prospective Relapse Risk......Page 160
4.5 Alcohol Craving: A Learned Response? How to Assess the Impact of Learning......Page 162
4.5.1 Clinical Studies Trying to Link Craving and Relapse: Identifying Craving......Page 164
4.5.2 Computational Models of Phasic Dopamine Release......Page 166
4.6 Using Imaging to Make Clinical Diagnoses......Page 168
References......Page 169
5.1 Introduction......Page 177
5.2 Dissociation of Drug-Taking and Drug-Seeking Behaviors Using Self-Administration Models......Page 178
5.3 Influence of Genetic Background on Drug Self-Administration......Page 180
5.4 Cell-Specific Transgenic Expression in Drug Self-Administration Studies......Page 185
5.5 Cell- Specific Genetic Deletion in Mouse Self-Administration Studies......Page 197
5.6 Concluding Remarks......Page 201
References......Page 202
6.1 Introduction......Page 207
6.2.1 Neurobiology of Reward and Motivation......Page 208
6.2.2 Translating Value int o Choices: The Neuroeconomic Approach......Page 211
6.3.1 Social Rewards in Primates......Page 212
6.3.2 Neural Circuits Processing Social Rewards and Punishment......Page 215
6.4.1 Risk and Decision Making......Page 216
6.4.2 Neural Basis Decision Making under Conditions of Risk......Page 217
6.5.1 Drugs, Decisions, and Dopamine......Page 220
6.5.2 Drugs, Decisions, and Serotonin......Page 221
6.6 Conclusions......Page 223
References......Page 224
B......Page 231
C......Page 232
F......Page 233
N......Page 234
R......Page 235
Y......Page 236
Color Insert......Page 237
Back Page......Page 241