Advances in Immunology, Vol. 61

"The series which all immunologists need." --The Pharmaceutical Journal "Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science "Deserves a permanent place in biomedical libraries as an aid in research and in teaching" --Journal of Immunological Methods "A provocative and scholarly review of research" --Journal of the American Medical Association "Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject" --The Lancet "Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended." --Journal of Medical Microbiology "A very valuable serial publication...no serious student of immunology can afford to be without it." --Archives of Biochemistry and Biophysics Key Features * Focus on components of the V(D)J recombination machinery that might be related to diseases in humans and animals * Control of the complement system by control of C3/C5 convertase on host cells, control of fluid phase C3/C5 convertases, control of fluid phase MAC, and control of deposited MAC * Immunodeficiency resulting from a complete absence of MHC class II expression and two trans-acting factors controlling transcription * Current knowledge of IL-2R signaling, highlighting IL-2 signaling, and T-cell growth regulation * Functional role of CD40 in cells, the in vivo significance of CD40-CD40-L interactions, and the signal transduction machinery activated following crosslinking of the CD40 antigen * Integrative approach to better understand the observed heterogeneity of an individual response to allergens * Regulation of isotype specificity, switch recombination regulation, and the mechanism of switching * Two lymphocyte-specific proteins, RAG1 and RAG2, initiate V(D)J recombination of antigen receptor genes