This first edition of the textbook “Adrenocortical Carcinoma: Basic Sciences and Clinical Concepts” provides a concise compilation of relevant data advancing our current understanding of this rare cancer. Chapters are dedicated to various aspects of both the basic biology and the clinical science relating to adrenocortical carcinoma (ACC). Expert clinicians introduce the reader to current state-of-the-art clinical care of patients with ACC. As a considerable body of knowledge on ACC has accumulated over the last decades, expert scientists have authored additional sections that serve as a reference source for the experienced researcher as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span the epidemiology, diagnosis and therapy of ACC. Scientific topics areas span the pathology and pathophysiology of ACC with a special focus on experimental models of adrenocortical tumors and recent advances in the genetic aspects and signaling pathways in ACC. The content of this book was compiled and edited with the intent of facilitating the translation of knowledge into future diagnostic and therapeutic tools that will ultimately improve patient care.
Author(s): David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 546
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xv
Front Matter....Pages 1-1
The History of Adrenocortical Carcinoma Treatment – A Medical Perspective....Pages 3-8
The History of Adrenocortical Carcinoma Treatment – A Surgical Perspective....Pages 9-19
Front Matter....Pages 21-21
Epidemiology of Adrenocortical Carcinoma....Pages 23-29
Clinical Presentation and Initial Diagnosis....Pages 31-47
Diagnostic Approach to Incidentaloma....Pages 49-64
Front Matter....Pages 65-65
Computed Tomography/Magnetic Resonance Imaging of Adrenocortical Carcinoma....Pages 67-84
Functional Imaging of Adrenocortical Carcinoma....Pages 85-103
Front Matter....Pages 105-105
Classical Histopathology and Immunohistochemistry....Pages 107-126
Cellular and Molecular Pathology of Adrenocortical Carcinoma....Pages 127-150
Front Matter....Pages 151-151
Overview of Genetic Syndromes Associated with Adrenocortical Cancer....Pages 153-172
Li–Fraumeni Syndrome....Pages 173-191
TP53 Molecular Genetics....Pages 193-205
Telomeres and Telomerase in Adrenocortical Carcinoma....Pages 207-225
Beckwith–Wiedemann Syndrome....Pages 227-234
The Insulin-Like Growth Factor System in Adrenocortical Growth Control and Carcinogenesis....Pages 235-262
WNT/β-Catenin Signaling in Adrenocortical Carcinoma....Pages 263-282
Front Matter....Pages 283-283
Adrenocortical Stem and Progenitor Cells: Implications for Cancer....Pages 285-304
Adrenocortical Cell Lines....Pages 305-324
Mouse Models of Adrenal Tumorigenesis....Pages 325-340
Front Matter....Pages 341-341
Overview of Treatment Options for Adrenocortical Carcinoma....Pages 343-349
Front Matter....Pages 341-341
Chemotherapy....Pages 351-368
Mitotane....Pages 369-381
Pharmacotherapy for Hormone Excess in Adrenocortical Carcinoma....Pages 383-402
Surgery for Adrenocortical Carcinoma....Pages 403-425
Radiation Therapy for Adrenocortical Carcinoma....Pages 427-441
Follow-Up and Monitoring of Adrenocortical Carcinoma....Pages 443-453
Front Matter....Pages 455-455
Aldosterone-Producing Adrenocortical Carcinoma....Pages 457-465
Adrenocortical Cancer in Children....Pages 467-481
Genome-Wide Studies in Adrenocortical Neoplasia....Pages 483-491
New Strategies for the Treatment of Adrenocortical Carcinoma....Pages 493-513
Front Matter....Pages 515-515
The Dutch Adrenal Network....Pages 517-519
The ENS@T Initiative....Pages 521-531
Back Matter....Pages 533-546
