Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition.
Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Author(s): Bertil B. Fredholm (auth.), Susan Masino, Detlev Boison (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2013
Language: English
Pages: 680
Tags: Neurosciences; Neurobiology
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Adenosine and Metabolism—A Brief Historical Note....Pages 3-19
Front Matter....Pages 21-21
Adenosine Metabolism, Adenosine Kinase, and Evolution....Pages 23-54
Adenosine and Energy Metabolism—Relationship to Brain Bioenergetics....Pages 55-70
Adenosine and Autocrine Metabolic Regulation of Neuronal Activity....Pages 71-85
Physiologic and Metabolic Regulation of Adenosine: Mechanisms....Pages 87-107
The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books....Pages 109-129
Downstream Pathways of Adenosine....Pages 131-156
Astrocytic ATP Release....Pages 157-177
Role of Striatal A 2A Receptor Subpopulations in Neurological Disorders....Pages 179-197
Front Matter....Pages 199-199
Sleep and Adenosine: Human Studies....Pages 201-212
Adenosine and Other Purinergic Products in Circadian Timing....Pages 213-232
Adenosine in the Immune System....Pages 233-251
The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation....Pages 253-272
Adenosine and Stroke....Pages 273-306
The Many Roles of Adenosine in Traumatic Brain Injury....Pages 307-322
Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury....Pages 323-342
Adenosine and Pain....Pages 343-360
Symptomatic and Neuroprotective Effects of A 2A Receptor Antagonists in Parkinson’s Disease....Pages 361-384
Adenosine Receptors and Alzheimer’s Disease....Pages 385-407
Adenosine Receptors in Huntington’s Disease....Pages 409-434
Front Matter....Pages 199-199
Adenosine and Multiple Sclerosis....Pages 435-457
Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis....Pages 459-491
The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation....Pages 493-512
Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities....Pages 513-533
Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes....Pages 535-558
Front Matter....Pages 559-559
Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation....Pages 561-579
Ketogenic Diet and Epilepsy: The Role of Adenosine....Pages 581-598
Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery....Pages 599-620
Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy....Pages 621-656
Back Matter....Pages 657-679
