As the third leading cause of death in the United States, stroke accounts for one in every fifteen deaths and is the major cause of disability in the country. Compiled by a renowned editorial team, this reference bridges the gap between basic science and patient care protocols, and collects 43 expertly written chapters that range from laboratory-based research on animal models to the progression, mechanisms, treatment, and prognosis of diseases such as subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), focal ischemic stroke, and global cerebral ischemia.
Author(s): Anish Bhardwaj, Nabil J. Alkayed, Jeffrey R. Kirsch, Richard J. Traystman
Edition: 1
Year: 2006
Language: English
Pages: 515
Cover Page......Page 1
NEUROLOGICAL DISEASE AND THERAPY......Page 3
Title Page......Page 10
ISBN 0849398703......Page 11
Foreword......Page 14
Preface......Page 16
Contents (with page links)......Page 18
Contributors......Page 28
1. Animal Models of Subarachnoid Hemorrhage ......Page 34
2. Pathogenesis of Cerebral Aneurysm Growth and Rupture ......Page 48
3. Pathogenesis of Cerebral Vasospasm ......Page 62
4. Surgical Management of Aneurysmal Subarachnoid Hemorrhage ......Page 78
5. Endovascular Management of a Patient After Subarachnoid Hemorrhage ......Page 86
6. Intraoperative Management of Aneurysmal Subarachnoidal Hemorrhage ......Page 100
7. Medical Management of Subarachnoid Hemorrhage ......Page 114
8. Clinical Trials in Subarachnoid Hemorrhage ......Page 126
9. Prognosis and Outcomes Following Aneurysmal Subarachnoid Hemorrhage ......Page 136
10. Animal Models of Intracerebral Hemorrhage ......Page 144
11. Pathophysiologic Mechanisms of Brain Injury Following Intracerebral Hemorrhage ......Page 156
12. Surgical Management of Intracerebral Hemorrhage ......Page 166
13. Medical Management of Intracerebral Hemorrhage ......Page 174
14. Clinical Trials in Intracerebral Hemorrhage ......Page 184
15. Prognosis and Outcomes Following Intracerebral Hemorrhage ......Page 194
16. Animal Models of Ischemic Stroke ......Page 204
17. Pathogenesis of Brain Injury Following Ischemic Stroke ......Page 220
18. Neuroimaging in Ischemic Stroke ......Page 238
19. Thrombolytic Therapy for Acute Ischemic Stroke ......Page 250
20. Medical Management of Acute Ischemic Stroke ......Page 262
21. Clinical Neuroprotective Trials in Ischemic Stroke ......Page 276
22. Prognosis and Outcomes Following Ischemic Stroke ......Page 284
23. Venous Strokes and Venous Sinus Thrombosis ......Page 296
24. Animal Models of Global Cerebral Ischemia ......Page 308
25. Pathogenic Mechanisms of Brain Injury Following Global Cerebral Ischemia ......Page 326
26. Management of Brain Injury Following Cardiopulmonary Arrest ......Page 346
27. Prognosis and Neurologic Outcomes Following Cardiopulmonary Arrest ......Page 360
28. Failure of Neuroprotective Agents to Show Benefit in Clinical Trials ......Page 368
29. Ischemic Preconditioning ......Page 378
30. Therapeutic Potential of Hypothermia in Acute Stroke ......Page 388
31. Decompressive Hemicraniectomy for Stroke: An Old Therapy Revisited ......Page 398
32. Blood-Pressure Management in Subarachnoid Hemorrhage, Acute Ischemic Stroke, and Intracerebral Hemorrhage ......Page 408
33. Diagnosis and Treatment of Cerebral Arteriovenous Malformations ......Page 422
34. Endovascular Therapy for Carotid Stenosis ......Page 432
35. Acute Stroke Care Units: A Critical Appraisal ......Page 438
36. Telemedicine Applied to Stroke Care ......Page 448
37. Multimodality Neuromonitoring in Acute Stroke ......Page 454
38. Gender Differences in Stroke Pathobiology: Therapeutic Implications ......Page 466
39. Ultrasonography in the Management of Acute Stroke ......Page 476
40. Acute Stroke in the Young ......Page 492
41. Functional Recovery After Stroke with Cell-Based Therapy ......Page 506
42. Brain Attack ......Page 514
Appendix: Abbreviations......Page 522
Index (with page links)......Page 530
About the Editors......Page 548
