This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Author(s): Deepak Chhabra, Cristobal G. dos Remedios (auth.), Cristobal G. dos Remedios, Deepak Chhabra (eds.)
Series: Protein Reviews 8
Edition: 1
Publisher: Springer-Verlag New York
Year: 2008
Language: English
Pages: 348
City: New York
Tags: Proteomics; Cell Biology; Biochemistry, general
Front Matter....Pages i-xiv
Actin: An Overview of Its Structure and Function....Pages 1-15
Actin Genetic Diseases....Pages 16-36
Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells....Pages 37-49
Autoantigenicity of Actin....Pages 50-64
Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology....Pages 65-82
ADF/Cofilin, Actin Dynamics, and Disease....Pages 83-187
Gelsolin and Disease....Pages 188-199
Profilin....Pages 200-217
The Roles of Thymosin β 4 in Cell Migration and Cell-to-Cell Signaling in Disease....Pages 218-228
Actin and Actin-Binding Proteins in Cancer Progression and Metastasis....Pages 229-277
Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells....Pages 278-289
The Role of PIP 2 in Actin, Actin-Binding Proteins and Disease....Pages 290-297
Intracellular Pathogens and the Actin Cytoskeleton....Pages 298-317
Actin and Its Binding Proteins in Heart Failure....Pages 318-334
Back Matter....Pages 335-348
