Those who responded to the COVID-19 pandemic have now had the opportunity to reflect on lessons learned, and in this science and data-rich book, those reflections are presented as a behind-the-scenes chronology of events and discoveries that occurred in COVID-19's wake. Offering a rubric for a future pandemic response, each chapter is written by experts, with their unique perspectives, experience, and learnings woven into visual roadmaps throughout the book. These roadmaps serve as a scaffolding upon which future healthcare leaders can build when creating, implementing and executing operational strategies in the face of future infectious disease outbreaks. Written for both lay and scientific audiences and featuring case studies which give clinical insight into the unique bond between COVID patients, their loved ones and their healthcare providers, this important book allows readers to leverage the knowledge of experts to improve the outcomes of future pandemics.
Provides guidance for future pandemic response in a visual format of roadmaps per chapter, displaying vital activities, their chronology, and an estimated timeframe
Featuring broad and comprehensive coverage of the US national response to COVID-19 as captured by experts who were on the ground
Case studies are used throughout, offering clinical insight into the unique bond between COVID patients, their loved ones, and their healthcare providers
Author(s): Steven C. Schachter, Wade E. Bolton
Edition: 1
Publisher: Cambridge University Press
Year: 2024
Language: English
Commentary: TRUE PDF, NO BOOKMARKS
Tags: COVID-19; Future Pandemics; Diagnostics; Epidemiology; Public Health; Global Crisis
List of Contributors ix
Foreword xiii
Harvey V. Fineberg
Preface xv
Wade E. Bolton
Acknowledgments xvii
Introduction 1
Tania Fernandez
1 Early Detection, Response,
and Surveillance of the COVID-19
Pandemic Crisis 6
Enrique M. Rabellino, Alexandra
Smith, and Marta C. Cohen
2 Immunology of COVID-19
and Ineffective Immunity 31
Adolfo Firpo-Betancourt and Enrique
M. Rabellino
3 Clinical Management: A Roadmap
Based on One New York City
Hospital’s Response to the COVID-19
Pandemic 50
Barbara Barnett, Yvette Calderon,
Bethany Kranitzky, Young Im Lee, Erick
Eiting, Lina Miyakawa, Waleed Javaid,
and Saralynne Brown
4 Contribution of RADx® Tech
to the Rapid Development
of COVID-19 Diagnostic Tests 74
Steven C. Schachter, John M. Collins,
Michael K. Dempsey, Laura L.
Gibson, Matthew L. Robinson, and
Paul Tessier
5 Coordination of Resources for the
Manufacturing and Deployment of
COVID-19 Diagnostic Assays 88
Maren Downing, Mia Cirrincione,
Adam Samuta, Kevin Leite, Sam
Dolphin, Emily Muth, Jose Valdesuso,
and Brian Walsh
6 Quality and Risk Management
Processes for Diagnostic Assays
during an Emergency Pandemic
Response 103
Devon C. Campbell and Christie Johnson
7 Development of Assays to Diagnose
COVID-19 125
Yukari C. Manabe and William Clarke
8 Laboratory Verification and Clinical
Validation of COVID-19 Diagnostic
Assays 143
Anuradha Rao, Leda Bassit, Julie
Sullivan, Wilbur Lam, and Jennifer
K. Frediani
9 Importance of Timely Sequencing,
Tracking, and Surveillance
of Emergent Variants 166
Jessica Lin, Morgan Greenleaf, Yang
Lu, Leda Bassit, Cassandra Wesselman,
and Anne Piantadosi
10 The RADx® Regulatory Core
and Its Role in COVID-19 Emergency
Use Authorizations 194
Erika Tyburski and Cathryn Cambria
11 Commercialization and Market
Assessment of COVID-19 Assays 211
Manuel Kingsley, Sunshine Moore,
Heath Naquin, Eliseo Velasquez, Emily
Kennedy, and Grace Bendinger
12 Testing Strategies to Mitigate
COVID-19 Disease Spread 236
Paul Tessier and Anette
E. Hosoi
13 A Pandemic Not Just of Infection
but of Inequality: The Social
Impact of COVID-19 250
Mara Aspinall and Liz Ruark
14 Summary and Path Forward
for Future Pandemics 263
Wade E. Bolton and Steven
C. Schachter
Index 274
