ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Key Features * Phylogeny and Evoloution of ABC Transporters * Fundamental Aspects of the Mechanism of Action of ABC Transporters * Prokaryote ABC Transporters * Non-Mammalian Transporters * Multidrug Transporters * ABC Transporters, Physiological Roles and Human Disease * Full color throughout
Author(s): I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins
Edition: 1
Publisher: Academic Press
Year: 2003
Language: English
Pages: 631
Cover......Page 1
CONTRIBUTORS......Page 2
ABC TRANSPORTERS: AN INTRODUCTION AND
OVERVIEW......Page 9
PHYLOGENETIC AND
FUNCTIONAL CLASSIFICATION
OF ABC (ATP-BINDING
CASSETTE) SYSTEMS......Page 16
MEMBRANE TOPOLOGY OF THE
HUMAN ABC TRANSPORTER
PROTEINS......Page 49
HUMAN AND DROSOPHILA
ABC PROTEINS......Page 59
STRUCTURE OF ABC
TRANSPORTERS......Page 74
SUBSTRATE-BINDING SITES IN
ABC TRANSPORTERS......Page 90
PROBING OF CONFORMATIONAL
CHANGES, CATALYTIC CYCLE
AND ABC TRANSPORTER
FUNCTION......Page 115
X-RAY STRUCTURE OF AN
INTACT ABC TRANSPORTER,
MSBA......Page 142
INTRODUCTION TO BACTERIAL
ABC PROTEINS......Page 154
IMPORT OF SOLUTES BY ABC
TRANSPORTERS – THE MALTOSE
AND OTHER SYSTEMS......Page 161
CRYSTAL STRUCTURES OF
PERIPLASMIC SOLUTE-BINDING
PROTEINS IN ABC TRANSPORT
COMPLEXES ILLUMINATE THEIR
FUNCTION......Page 190
BACTERIAL ABC TRANSPORTERS
INVOLVED IN PROTEIN
TRANSLOCATION......Page 211
BACTERIALMULTIDRUG
RESISTANCEMEDIATED BY ABC
TRANSPORTERS......Page 244
STRUCTURE AND FUNCTION OF
OSMOREGULATED ABC
TRANSPORTERS......Page 264
INVENTORY AND EVOLUTION OF
FUNGAL ABC PROTEIN GENES......Page 277
FUNGAL ABC PROTEINS
IN CLINICAL DRUG
RESISTANCE AND CELLULAR
DETOXIFICATION......Page 292
DRUG RESISTANCEMEDIATED
BY ABC TRANSPORTERS IN
PARASITES OF HUMANS......Page 314
THE PLANT ABC TRANSPORTER
SUPERFAMILY: THE FUNCTIONS
OF A FEW AND IDENTITIES
OF MANY......Page 331
SOLVING THE PROBLEM OF
MULTIDRUG RESISTANCE: ABC
TRANSPORTERS IN CLINICAL
ONCOLOGY......Page 352
MULTIDRUG RESISTANCE
PROTEIN 1 (ABCC1)......Page 385
MRP2, THE APICAL EXPORT
PUMP FOR ANIONIC
CONJUGATES......Page 415
THE MULTIDRUG RESISTANCE
PROTEINS 3–7......Page 436
LIPID TRANSPORT BY ABC
TRANSPORTERS......Page 450
ROLE OF ABCA1 IN CELL
TURNOVER AND LIPID
HOMEOSTASIS......Page 468
PEROXISOMAL ABC
TRANSPORTERS......Page 486
ABC TRANSPORTERS IN
MITOCHONDRIA......Page 503
THE TRANSPORTER ASSOCIATED
WITH ANTIGEN PROCESSING......Page 520
THE SULFONYLUREA RECEPTOR:
AN ABCC TRANSPORTER THAT
ACTS AS AN ION CHANNEL
REGULATOR......Page 538
ABC TRANSPORTERS AND
HUMAN EYE DISEASE......Page 563
THE CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE REGULATOR
(ABCC7)......Page 574
ABC PROTEINS, THE
FASCINATION, THE POLITICS,
THE POTENTIAL FOR
APPLICATIONS FOR IMPROVING
HUMAN HEALTH......Page 604
Index......Page 609
