If you understand how drugs work (pharmacodynamics), how they are handled by the body (pharmacokinetics), how they interact with each other, and how drug treatments are assessed, then you will become a better prescriber. A Textbook of Clinical Pharmacology and Therapeutics gives you that understanding. Fully revised throughout and extensively illustrated, the fifth edition of this well-established textbook has been streamlined to focus on what medical students and junior doctors really need to know in order to understand the implications of prescribing one drug over, or in combination with, another. The text provides current information on all areas of drug prescribing with updated discussion and guidance on such topics as adverse drug reactions, personalized medicine, gene and cell-based therapy, advances in cancer therapy, and mechanisms of drug action and treatment guidelines in HIV and mycobacterial infections therapy. A new chapter on alternative medicines and nutraceuticals has been introduced and Further Reading lists have been updated to include key medical websites. All medical students and junior doctors who read this book will learn not only how to use drugs safely and effectively, but, importantly, the rationale behind effective prescribing decisions.
Author(s): James M Ritter, Lionel D Lewis, Timothy GK Mant, Albert Ferro
Series: A Hodder Arnold Publication
Edition: 5
Publisher: Oxford University Press, USA
Year: 2008
Language: English
Pages: 476
Book title......Page 4
CONTENTS......Page 8
FOREWORD......Page 9
PREFACE......Page 10
ACKNOWLEDGEMENTS......Page 11
PART I: GENERAL PRINCIPLES......Page 12
1 Introduction to therapeutics......Page 14
2 Mechanisms of drug action (pharmacodynamics)......Page 17
3 Pharmacokinetics......Page 22
4 Drug absorption and routes of administration......Page 28
5 Drug metabolism......Page 35
6 Renal excretion of drugs......Page 42
7 Effects of disease on drug disposition......Page 45
8 Therapeutic drug monitoring......Page 52
9 Drugs in pregnancy......Page 56
10 Drugs in infants and children......Page 63
11 Drugs in the elderly......Page 67
12 Adverse drug reactions......Page 73
13 Drug interactions......Page 82
14 Pharmacogenetics......Page 90
15 Introduction of new drugs and clinical trials......Page 97
16 Cell-based and recombinant DNA therapies......Page 103
17 Alternative medicines: herbals and nutraceuticals......Page 108
PART II: THE NERVOUS SYSTEM......Page 114
18 Hypnotics and anxiolytics......Page 116
19 Schizophrenia and behavioural emergencies......Page 121
20 Mood disorders......Page 127
21 Movement disorders and degenerative CNS disease......Page 135
22 Anti-epileptics......Page 144
23 Migraine......Page 153
24 Anaesthetics and muscle relaxants......Page 156
25 Analgesics and the control of pain......Page 166
PART III: THE MUSCULOSKELETAL SYSTEM......Page 176
26 Anti-inflammatory drugs and the treatment of arthritis......Page 178
PART IV: THE CARDIOVASCULAR SYSTEM......Page 186
27 Prevention of atheroma: lowering plasma cholesterol and other approaches......Page 188
28 Hypertension......Page 196
29 Ischaemic heart disease......Page 207
30 Anticoagulants and antiplatelet drugs......Page 215
31 Heart failure......Page 222
32 Cardiac dysrhythmias......Page 228
PART V: THE RESPIRATORY SYSTEM......Page 242
33 Therapy of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory disorders......Page 244
PART VI: THE ALIMENTARY SYSTEM......Page 256
34 Alimentary system and liver......Page 258
35 Vitamins and trace elements......Page 276
PART VII: FLUIDS AND ELECTROLYTES......Page 282
36 Nephrological and related aspects......Page 284
PART VIII: THE ENDOCRINE SYSTEM......Page 294
37 Diabetes mellitus......Page 296
38 Thyroid......Page 303
39 Calcium metabolism......Page 308
40 Adrenal hormones......Page 313
41 Reproductive endocrinology......Page 318
42 The pituitary hormones and related drugs......Page 327
PART IX: SELECTIVE TOXICITY......Page 332
43 Antibacterial drugs......Page 334
44 Mycobacterial infections......Page 345
45 Fungal and non-HIV viral infections......Page 351
46 HIV and AIDS......Page 362
47 Malaria and other parasitic infections......Page 372
48 Cancer chemotherapy......Page 378
PART X: HAEMATOLOGY......Page 398
49 Anaemia and other haematological disorders......Page 400
PART XI: IMMUNOPHARMACOLOGY......Page 408
50 Clinical immunopharmacology......Page 410
PART XII: THE SKIN......Page 420
51 Drugs and the skin......Page 422
PART XIII: THE EYE......Page 432
52 Drugs and the eye......Page 434
PART XIV: CLINICAL TOXICOLOGY......Page 442
53 Drugs and alcohol abuse......Page 444
54 Drug overdose and poisoning......Page 455
A......Page 462
C......Page 464
D......Page 466
F......Page 467
H......Page 468
I......Page 469
M......Page 470
N......Page 471
P......Page 472
S......Page 474
T......Page 475
Z......Page 476
