This book examines animal research conducted with the goal of medical translation to humans. It is written by Dr. Bradley Weiner, a surgeon who is active at a high level clinically and in biomedical research. After documenting that the vast majority of biomedical animal research fails to result in benefits to humans via translation, the book examines the sources of such failure; including the failure to justify the use of animals, the failure to properly apply scientific methods, the failure to perform the research properly in the lab, the failure to consider the possibility of translation a priori, and systematic sources of failure built into the biomedical research enterprise. The book then explores options to improve the situation, for the benefit of both the animals and humans.
Author(s): Bradley K. Weiner
Publisher: Springer
Year: 2023
Language: English
Pages: 71
City: Cham
Preface
Introduction
Acknowledgments
Contents
Chapter 1: Critique
1 Failures of Justification
2 Failures of Scientific Methodology
3 Failures of Performance
A sample “Materials and Methods”
4 Failures of Translatability
5 Systematic Failures
6 Summary of the Critique
Chapter 2: Constructive
1 Justification
2 Scientific Methodology
3 Performance
4 Translatability
5 Systematic Failures
6 Summary of Constructive Section
Chapter 3: Putting It All Together: Hope Moving Forward
References
A. Specific References Delineating the ‘Problem’ Referred in Opening Section
B. General References Delineating the ‘Problem’
C. General References Regarding Justification
D. General References Regarding Methodology
E. General References Regarding Performance
F. General References Regarding Translatability
G. General References Regarding Systematic Issues
