In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics. The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations. Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.
Author(s): Milo Keynes, A. W. F. Edwards, Robert Peel
Series: Frontiers
Edition: 1
Publisher: CRC Press
Year: 2004
Language: English
Pages: 170
City: Boca Raton
BookCover......Page 1
Half-Title......Page 2
Title......Page 4
Copyright......Page 5
Contents......Page 6
Notes on the Contributors......Page 8
Preface......Page 10
The First Fifty Years of Mendelism......Page 12
1. The Introduction of Mendelism into Human Genetics......Page 13
2. Gallon’s Theory of Ancestral Inheritance......Page 22
3. The Reception of Mendelism by the Biometricians and the Early Mendelians (1899-1909)......Page 28
4. Mendelism and Man 1918-1939......Page 42
5. William Bateson, Archibald Garrod and the Nature of the “Inborn”I......Page 55
Human Genetics from 1950......Page 70
6. Linkage and Allelic Association......Page 71
7. Malaria and Darwinian Selection in Human Populations......Page 84
8. Chromosomal Genetics and Evolution......Page 96
9. Mendelian Disorders in Man: The Development of Human Genetics......Page 108
10. The Genetics of Complex Diseases......Page 138
11. Human Cancer Genetics......Page 145
Appendix......Page 163
