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A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world. * Presents state-of-the-art developments in organic synthesis * Provides insight and offers new perspective to problem-solving * Written by leading experts in the field. Read more... Content: Chapter 1 Total Synthesis of Rk-397total Synthesis of Rk-397 -- Chapter 2 a Formal Total Synthesis of the Marine -- Diterpenoid, Diisocyanoadociane -- Chapter 3 Total Syntheses of Zoapatanol -- Chapter 4 Synthesis of Molecular Tweezers and -- Clips by the Use of a Molecular Lego Set and Their Supramolecular Functions -- Chapter 5 Application of C-glycosides in the Total Synthesis of ( -- )-gambierol -- Chapter 6 a Biomimetic Approach to the Ocaglamides Employing Photogeneration of Oxidopyryliums -- Derived from 3-hydroxyflavones -- Chapter 7 Synthesis Studies of Dolabellanes and Transannular Processes Leading to Related Diterpenes -- Chapter 8 Diphenyloxazinones: Versatile Templates -- for the Asymmetric Synthesis of [alpha]-amino Acids, Peptide Isosteres, and Natural Products -- Chapter 9 Rhodium-catalyzed Cycloisomerization -- Reactions of Allenes in Diversity-oriented -- Synthesis -- Chapter 10 Hydrogen-bond-mediated Organic Synthesis in the Solid State -- Chapter 11 Total Syntheses of Natural Products -- Using the Combined C-h Activation/cope Rearrangement as the Key Step -- Chapter 12 the Total Synthesis of Amphibian -- Alkaloids Using the Intramolecular Schmidt Reaction -- Chapter 13 Seduced by a Sirens Call: Expanding -- Applications for Aromatic Compounds and the Synthesis of (+)-rishirilide B. Abstract: Presents developments in organic synthesis and provides insight and offers several perspectives to problem-solving. This book provides a forum for investigators to discuss their approach to the science and art of organic. Read more...

Author(s): Michael Harmata (Eds.)
Series: Strategies and Tactics in Organic Synthesis 7
Publisher: Academic
Year: 2008

Language: English
Pages: 1-506
City: London

Content:
Dedication
Page v

Contributors
Pages xv-xvi

Preface
Pages xvii-xviii
Michael Harmata

Foreword
Page xix
Gilbert Stork

Chapter 1 Total synthesis of RK-397 Original Research Article
Pages 1-34
Scott E. Denmark, Shinji Fujimori

Chapter 2 A formal total synthesis of the marine diterpenoid, diisocyanoadociane Original Research Article
Pages 35-58
Kelly A. Fairweather, Simon R. Crabtree, Lewis N. Mander

Chapter 3 Total syntheses of zoapatanol Original Research Article
Pages 59-98
Janine Cossy, Véronique Bellosta, Catherine Taillier

Chapter 4 Synthesis of molecular tweezers and clips by the use of a molecular lego set and their supramolecular functions Original Research Article
Pages 99-153,I-V
Frank-Gerrit Klärner, Mireia Campañá Kuchenbrandt

Chapter 5 Application of C-glycosides in the total synthesis of (−)-gambierol Original Research Article
Pages 154-218
Jon D. Rainier

Chapter 6 A biomimetic approach to the rocaglamides employing photogeneration of oxidopyryliums derived from 3-hydroxyflavones Original Research Article
Pages 219-242,VI-VIII
John A. Porco Jr, Baudouin Gerard

Chapter 7 Synthesis studies of dolabellanes and transannular processes leading to related diterpenes Original Research Article
Pages 243-267
David R. Williams

Chapter 8 Diphenyloxazinones: versatile templates for the asymmetric synthesis of α-amino acid, peptide isosteres, and natural products Original Research Article
Pages 268-327
Robert M. Williams, Cameron M. Burnett

Chapter 9 Rhodium-catalyzed cycloisomerization reactions of allenes in diversity-oriented synthesis Original Research Article
Pages 328-367,IX-X
Kay M. Brummond, Branko Mitasev

Chapter 10 Hydrogen-bond-mediated organic synthesis in the solid state Original Research Article
Pages 368-382
Leonard R. MacGillivray

Chapter 11 Total syntheses of natural products using the combine C-H activation/cope rearrangement as the key step Original Research Article
Pages 383-407
Huw M.L. Davies, Xing Dai

Chapter 12 The total synthesis of amphibian alkaloids using the intramolecular schmidt reaction Original Research Article
Pages 408-459
Kevin J. Frankowski, Aaron Wrobleski, Jeffrey Aubé

Chapter 13 Seduced by a siren's call: expanding applications for aromatic compounds and the synthesis of (+)-rishirilide B Original Research Article
Pages 460-490
Thomas Pettus, Todd Wenderski

Index
Pages 491-506