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Senolytics in Disease, Ageing and Longevity

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Author(s): Daniel Muñoz-Espin
Publisher: Springer publishing
Year: 2020

Language: english
Pages: 320
Tags: Senolytic;Aging

Front Matter
Part I. Origins and Development of Senotherapies
1. Senolytic Drug Development
2. Discovery of Senolytics and the Pathway to Early Phase Clinical Trials
Part II. The Impact of Senotherapies: From Regeneration to Aging
3. Interconnection Between Cellular Senescence, Regeneration and Ageing in Salamanders
4. Senolytics Target Senescent Cells and Improve Aging and Age-Related Diseases
5. Senotherapy of Cancer
Part III. Understanding and Targeting the Senescent Surfaceome
6. Targeted Senolytic Strategies Based on the Senescent Surfaceome
7. Senolysis and Senostasis Through the Plasma Membrane
Part IV. Novel Senescence-Associated Markers and Targets
8. In Situ Detection of miRNAs in Senescent Cells in Archival Material
9. Novel Probes and Carriers to Target Senescent Cells
10. Potential Applications of Aptamers for Targeting Senescent Cells
11. Mitochondria: Potential Targets for Interventions to Counteract Senescence