This best-selling and widely used resource on pediatric antimicrobial therapy provides instant access to reliable, up-to-the-minute recommendations for treatment of all infectious diseases in children.
For each disease, the authors provide a commentary to help health care providers select the best of all antimicrobial choices. Drug descriptions cover pediatric-appropriate antimicrobials and include complete information about dosing regimens. In response to growing concerns about overuse of antibiotics, the program includes guidelines on when not to prescribe antibiotics.
Now in color to help you find the best options quickly!
New in the 25th edition:
• Includes recommendations for new intravenous broad-spectrum beta-lactam/beta-lactamase inhibitor combinations.
• Provides options for treatment of increasing resistance in Escherichia coli for urinary tract infections.
• Includes updates for management of diarrhea, including recommendations for Giardia with tinidazole and nitazoxanide as drugs of choice, based on the new Infectious Diseases Society of America (IDSA) guidelines.
• Clarifies specific, new, and evolving recommendations about antifungal therapeutic drug levels for several invasive fungal infections, particularly in immunocompromised children.
• Reorganizes antiviral table for easier reading: common viral pathogens are in one table and HIV, hepatitis B, and hepatitis C are in a second table.
• Provides guidance for neonates during the ongoing cefotaxime shortage, including alternatives to achieve similar antibacterial activity in similar tissue sites, with a similar safety profile.
• Includes updates, such as new information on drug therapy and steroid therapy for neurocysticercosis, incorporating the new IDSA and American Society of Tropical Medicine and Hygiene guidelines.
• Incorporates new IDSA coccidioidomycosis guidelines in updated recommendations.
• Simplifies navigation with color-coded tabs and tables that make it easier to find the best treatment options for susceptibility of bacterial, fungal, viral, and parasitic pathogens.
Author(s): John D. Nelson, John S. Bradley, Elizabeth D. Barnett, Joseph B. Cantey
Edition: 25th Edition
Publisher: American Academy of Pediatrics
Year: 2019
Language: English
Commentary: TRUE PDF
Pages: 331
Tags: Pediatrics; Pharmacology
Contents......Page 6
Introduction......Page 8
Notable Changes to 2019 Nelson’s Pediatric Antimicrobial Therapy, 25th Edition......Page 12
1. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones......Page 14
2. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins......Page 22
3. How Antibiotic Dosages Are Determined Using Susceptibility Data, Pharmacodynamics, and Treatment Outcomes......Page 30
4. Approach to Antibiotic Therapy of Drug-Resistant Gram-negative Bacilliand Methicillin-Resistant Staphylococcus aureus......Page 34
5. Antimicrobial Therapy for Newborns......Page 42
A. Recommended Therapy for Selected Newborn Conditions......Page 43
B. Antimicrobial Dosages for Neonates......Page 64
C. Aminoglycosides......Page 68
E. Use of Antimicrobials During Pregnancy or Breastfeeding......Page 69
6. Antimicrobial Therapy According to Clinical Syndromes......Page 72
A. Skin and Soft Tissue Infections......Page 75
B. Skeletal Infections......Page 81
C. Eye Infections......Page 84
D. Ear and Sinus Infections......Page 88
E. Oropharyngeal Infections......Page 91
F. Lower Respiratory Tract Infections......Page 94
G. Cardiovascular Infections......Page 107
H. Gastrointestinal Infections......Page 114
I. Genital and Sexually Transmitted Infections......Page 121
J. Central Nervous System Infections......Page 125
K. Urinary Tract Infections......Page 130
L. Miscellaneous Systemic Infections......Page 132
7. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 140
A. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Positive)......Page 141
B. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Gram Negative)......Page 143
C. Common Bacterial Pathogens and Usual Pattern of Susceptibility to Antibiotics (Anaerobes)......Page 145
D. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 147
8. Preferred Therapy for Specific Fungal Pathogens......Page 168
A. Overview of More Common Fungal Pathogens and Their Usual Pattern
of Antifungal Susceptibilities......Page 169
B. Systemic Infections......Page 171
C. Localized Mucocutaneous Infections......Page 185
9. Preferred Therapy for Specific Viral Pathogens......Page 186
B. Overview of Hepatitis B or C Viral Pathogens and Usual Pattern of Susceptibility to Antivirals......Page 187
C. Preferred Therapy for Specific Viral Pathogens......Page 189
10. Preferred Therapy for Specific Parasitic Pathogens......Page 202
A. Selected Common Pathogenic Parasites and Suggested
Agents for Treatment......Page 203
B. Preferred Therapy for Specific Parasitic Pathogens......Page 205
11. Alphabetic Listing of Antimicrobials......Page 224
A. Systemic Antimicrobials With Dosage Forms and Usual Dosages......Page 226
B. Topical Antimicrobials (Skin, Eye, Ear, Mucosa)......Page 247
12. Antibiotic Therapy for Children Who Are Obese......Page 254
13. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy) for Serious Infections......Page 258
14. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection......Page 260
A. Postexposure Antimicrobial Prophylaxis to Prevent Infection......Page 262
B. Long-term Antimicrobial Prophylaxis to Prevent Symptomatic New Infection......Page 269
C. Prophylaxis of Symptomatic Disease in Children Who Have Asymptomatic Infection/Latent Infection......Page 270
D. Surgical/Procedure Prophylaxis......Page 271
Appendix: Nomogram for Determining Body Surface Area......Page 276
References......Page 278
Index......Page 302
