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TB Meningitis - University of North Carolina at Chapel Hill

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TB Meningitis - University of North Carolina at Chapel Hill

TB Meningitis 9/29/2009 Morning Report Maggie Davis Hovda Incidence 2005: In the US there were 186 cases of meningeal TB, which accounted for 6.3% of all extrapulmonary TB In NC, there were 5 cases, 6.9% 2007: In the US, there were 170 cases of meningeal TB, again 6.3% of cases In NC, there were ...


Date added: February 12, 2012 - Views: 181

Meningitis - Creighton University

Meningitis Bacterial Viral ( aseptic) TB Fungal Chemical Parasitic ? Carcinomatous Meningitis Definition Bacterial meningitis is an inflammatory response to bacterial infection of the pia-arachnoid and CSF of the subarachnoid space Epidemiology Incidence is between 3-5 per 100,000 More than ...


Date added: September 24, 2011 - Views: 132

MENINGITIS - School of Medicine

Complications associated with encephalitis and ICP TB Meningitis Usually insidious: difficult to diagnose in early stages (fever 30%, URTI 20%) Rare in children in developed countries If untreated is usually fatal Meningitis usually occurs 3-6mths after primary infection 1 stage-lasts 1-2wk, ...


Date added: May 26, 2013 - Views: 23

Miliary TB Meningitis: MRI Findings in Three Patients

Miliary TB Meningitis: MRI Findings in Three Patients. 1Kartikasalwah AbdLatif, 1Mohd Nazri MN, 2Sobri Muda. 1Department of Diagnostic Imaging, Kuala Lumpur Hospital, Malaysia


Date added: November 6, 2012 - Views: 29

Meningitis 10 questions - Perelman School of Medicine at the ...

Meningitis Commonly Asked Questions Stephen J. Gluckman, M.D. Meningitis – Who was awake? Which of the following are true about cryptococcal meningitis?


Date added: October 7, 2011 - Views: 79

Slide 1

... 75% sensitive and 31% specific ELISA for TB meningitis Montoya (1991) – 30 kDa native antigen: (+) in 3 of 4 definite TBM, (-) in all normal & non-TBM cases Valenzuela (2000) – 38 kDa antigen: (+) in 1 of 1 definite TBM; specificity of 72% Montoya ...


Date added: October 20, 2011 - Views: 86

Lumbar Punctures - Medical University of South Carolina

1889- First procedure to access the dural space consisted of a cut down procedure to help decrease intracranial pressure in people in TB meningitis by Walter Essex Wynter


Date added: February 13, 2013 - Views: 26

Global Epidemiology of Pediatric Tuberculosis (TB)

Because TB meningitis is a deadly disease, it may be more likely to be correctly reported. Because this study showed that only 56% of cases of TB meningitis had been correctly registered, it suggests that recording and reporting of childhood pulmonary disease may be even more incomplete.


Date added: June 11, 2012 - Views: 25


... .15 mg/kg q 6 hours x 4 days Corticosteroids also important in management of TB meningitis Case Answers HIV Elisa negative, HIV RNA PCR negative HSV, VZV pcr negative Gram stain, culture negative Lyme ab negative, RPR/VDRL negative Enteroviral PCR of stool and CSF: positive Rash: ...


Date added: September 8, 2013 - Views: 7

Tuberculosis - University of South Carolina

... Granulomas in glomeruli heal or caseate Dysuria and hematuria IVP helpful Upper and lower GU tract Tuberculous Meningitis and Tuberculoma Tuberculoma Seizures and focal signs CT or MRI: contrast-enhanced ring lesions Miliary Tuberculosis Hematogenously disseminated TB Lesions are ...


Date added: October 30, 2011 - Views: 127

Diagnosis - Emory University

Meningitis and Encephalitis: Diagnosis and Treatment Update Definitions Meningitis – inflammation of the meninges Encephalitis – infection of the brain parenchyma Meningoencephalitis – inflammation of brain + meninges Aseptic meningitis – inflammation of meninges with sterile CSF ...


Date added: June 30, 2012 - Views: 27

meningitis.ppt - دانشگاه علوم پزشكي بيرجند

Meningitis, caused by a bacteria, is life threatening and requires urgent medical attention and treatment with antibiotics. Meningitis caused by a virus is very rarely life threatening but can cause the body to become very weak.


Date added: May 8, 2012 - Views: 68

TUBERCULOSIS... - NCC Pediatrics Residency at Walter Reed ...

... 1990 TB MENINGITIS primary seeding caseous lesion adjacent meninges growth/discharge usually insidious prophylaxis is preventive TB MENINGITIS 40% of cases ocur within 3 months of estimated onset of TB rarely < 1 month 90% with TB menningitis PPD positive 94% of these have positive CXR ...


Date added: November 12, 2011 - Views: 71

Cryptococcal meningitis and tuberculosis: Key considerations ...

Cryptococcal meningitis and tuberculosis: Key considerations on when to start ART? Dr. Andrew D Kambugu. Infectious Diseases Institute. Makerere University College of Health sciences


Date added: October 22, 2013 - Views: 15

Pediatric Tuberculosis - North Dakota Department of Health

Ethambutol/Ethionamide (ETH) Typically 6 month tx: all 4 drugs x 2 months, then INH/RIF x 4 months TB meningitis and disseminated TB: 9-12mo 4 drugs x 2mo, then 2 drugs x 7-10 mo. MDR and XDR TB: 4-6 drugs for 18-24 months HIV coinfection: ...


Date added: September 8, 2011 - Views: 56

TREATMENT OF TUBERCULOSIS, 2003 - Centers for Disease Control ...

Why a New TB Treatment Statement? ... to 9-month regimens that include INH and RIF are effective Corticosteroids used as adjunctive therapy for patients with TB meningitis and pericarditis If PZA cannot be used in the initial phase, ...


Date added: October 16, 2011 - Views: 46

Slide 1

TB Meningitis. Learning Objectives. Introduction. Global problem. Aetiology and pathogenesis . Clinical Features. Complications and clinical outcome. Diagnosis


Date added: April 17, 2014 - Views: 1

The role of the Childhood TB Subgroup in vaccine research

Meet EPI Support full coverage of BCG to newborns (quality of services, evaluation, documentation) Meet NTP TB meningitis, strains from pts < 15 yrs (quality of services, evaluation, documentation) BCG status of TB pts (by scar) recording Meet NHAP HIV+ among TB pts; ...


Date added: July 8, 2012 - Views: 8

TB in Tennessee The Good, the Bad, and the Ugly

TB in TennesseeThe Good, the Bad, and the Ugly. Jason Cummins, MPH. April 30, 2014. ... Pediatric TB Meningitis Case. 28 month-old Hispanic male. Source case: maternal grandmother. Brain tissue was AFB smear-positive and culture positive for TB. Sequelae:


Date added: July 24, 2014 - Views: 1

Meningitis and Encephalitis in the Older Patient

Meningitis and Encephalitis in the Older Patient Debra Bynum, MD Division of Geriatric Medicine University of North Carolina Chapel Hill April 2007


Date added: September 24, 2011 - Views: 122

Tuberculosis and The Immune Reconstitution Inflammatory Syndrome

... The study found a 6-fold increased risk of subsequent TB relapse in patients who experienced IRIS during early TB treatment. Cryptococcal meningitis treated with HAART, bilateral blindness: fundoscopy: bilateral papiloedema: IRIS?


Date added: October 27, 2011 - Views: 21

Tuberculosis - s, su

... Anergy Bone marrow or liver biopsy may be diagnostic TB Meningitis Age: < 5 y/o Low grade fever Headache Personality change Kernig&Brudzinski signs Cranial nerve palsy Seizure Increase ICP Coma CNS Tuberculoma TB Meningitis CT-Scan: Hydrocephalus, edema, ...


Date added: May 3, 2013 - Views: 25

HIV in the Tropics - Mayo Clinic

Cryptococcal relapse TB meningitis Immune Reconstitution Syndrome (IRIS) Chikungunya 34 yo male HIV+, newly diagnosed presents to healthcare. To determine whether HIV antiretroviral medications are needed, most developing country programs base need for ARVs on: ...


Date added: December 12, 2013 - Views: 5


BACTERIAL AND MYCOBACTERIAL INFECTIONS OF THE CNS Outline Acute bacterial meningitis Tb of the CNS Neurosyphilis ACUTE BACTERIAL MENINGITIS An acute inflammatory disease of the leptomeninges Bacteria may gain access to the ventriculo-subarachnoid space: - hematogenous-in the course of ...


Date added: June 29, 2014 - Views: 2

Unit 2 Diagnosis of Tuberculosis - Home — I-TECH Website

Additional Case: Answer 2 Treatment should begin right away when TB meningitis is one of the likely diagnoses Diagnosis of TB meningitis can be supported by: CSF showing lymphocytic meningitis AND negative India Ink CSF AFB culture ...


Date added: October 13, 2012 - Views: 11

Special Situations in the Treatment of MDR TB

Several reports detail poor outcomes of DR-TB meningitis. Most of the patients were HIV-infected and developed meningitis while already on treatment. Mortality in 2 series from South Africa, 1 in adults and 1 in children, ranged from 57% to 88%.


Date added: May 2, 2013 - Views: 9

MENINGITIS - Emory University

MENINGITIS Laurie J Burton, MD PEM Fellows Conference December 6, 2006 ... (>25 percent) can be seen in the CSF differential count Tb meningitis cerebrospinal fluid (CSF) white blood cell count of <1000/mm3, clear appearance of CSF, ...


Date added: May 9, 2012 - Views: 84

Communicable Disease Education - Montgomery County, Maryland

The TB bacteria are put into the air when a person with active TB disease of the lungs or throat coughs, sneezes, speaks, ... Meningitis Manifesation Meningitis infection is characterized by a sudden onset of fever, headache, and stiff neck. It is often accompanied by other symptoms, ...


Date added: May 10, 2013 - Views: 6

Pediatric Tuberculosis

BCG protects infants against tb meningitis and miliary disease No evidence of any BCG induced protective effective in HIV infected children. Documented BCG induced disseminated disease and adverse reactions.


Date added: September 18, 2013 - Views: 13


Microbiological Causes Of Chronic Cerebral Infection And Meningitis. A –Bacterial, Most important. a)Tuberculosis in Saudi Arabia


Date added: November 14, 2013 - Views: 8

Central Nervous System Manifestations of HIV Infection

Glucose Calcium Sodium Blood Gas Drugs India Ink Cryptococcal Ag Cytology TB culture Routine Culture ... Diffuse Disease Cryptococcal Meningitis Acute Infection HIV Dementia Tuberculous Meningitis CNS Syphilis Toxoplasma encephalitis Cytomegalovirus encephalitis Two key things to ALWAYS ...


Date added: November 14, 2011 - Views: 67

5.0 Principles of TB Treatment.ppt - ftp.cdc.gov - /

Module 5: Principles of Treatment Session Overview Aims of TB Treatment General Principles Treatment Guidelines Learning Objectives Describe 3 basic principles of TB treatment Explain the difference between the 4 treatment categories (Cat I-IV) Understand and describe when and why a regimen may ...


Date added: June 2, 2013 - Views: 4

Tuberculosis - Biol 448B: Fundamentals of Tropical Disease

TB of lymph nodes: swelling of lymph nodes TB meningitis: neurological symptoms including headache Spinal TB: Mobility impairments, pain General Characteristics Family ...


Date added: February 22, 2013 - Views: 30

Dr. Gadbaw - New England TB Consortium

Duration of therapy for TB meningitis in HIV After 2 months of four-drug therapy for meningitis caused by susceptible strains, continue INH and RIF for an additional 7-10 months, although optimal duration of therapy is not defined.


Date added: March 13, 2012 - Views: 7

PowerPoint Presentation

Deficits: TB meningitis must be considered (because there is often basilar meningitis) * CSF: High protein, Low glucose, lymphocytic pleocytosis * This CSF pattern seen in other disease, thus if TB meningitis highly suspected (tve, TST CSF ...


Date added: February 14, 2012 - Views: 6

Slide 1

Positive reaction to TST Should be further evaluated for LTBI or TB disease What factors make it more likely that this man’s positive reaction is due to TB infection? ... Urine samples for TB disease of kidneys Fluid samples from area around spine for TB meningitis 5.


Date added: September 23, 2011 - Views: 120

Diagnosis of Tuberculosis

Laboratory Diagnosis of Tuberculosis By Dr. Faten Aly Shoukry , Ph D Consultant & Head of Microbiology Department , Abbassia Chest Hospital Types of Tuberculous Infections I- Pulmonary Infection II- Extrapulmonary infections: a-TB Pleural effusion b- Tuberculous meningitis c- Millary ...


Date added: October 14, 2012 - Views: 37


In a published meta-analysis of BCG efficacy, it had a 64% protective effect in preventing TB meningitis in children and a 78% protective effect in preventing disseminated TB among children. Clearly, BCG has an important role in preventing serious disease in young children.


Date added: May 28, 2013 - Views: 16

TB bug - Course Websites | Biology Department | UNC Chapel Hill

BCG is clearly effective against miliary TB and TB meningitis But its effectiveness against pulmonary TB is controversial http://www.cheng.cam.ac.uk/ New attenuated strain vaccines and recombinant versions of BCG are now in Phase II and Phase III clinical trials Image from University of Oxford ...


Date added: June 11, 2012 - Views: 14

NEISSERIA - Download Center

... PowerPoint Presentation Other Causes Findings in CSF CSF in bacterial meningitis CSF in TB meningitis CSF in viral meningitis Cerebral abscess Complication of meningitis Treatment of meningitis ...


Date added: December 9, 2011 - Views: 65

Cryptococcal meningitis – addressing raised pressure

Title: Cryptococcal meningitis – addressing raised pressure Author: thozama dubula Last modified by: M NAIDU Document presentation format: On-screen Show


Date added: November 4, 2011 - Views: 33

Common mistakes of TB diagnosis at basic health care facilities

Although TB meningitis accounts for only 2% of all cases in TB patients, it is of disproportionate importance because of the significant morbidity and mortality associated with it. One of the most difficult diagnoses to make is that of cryptic miliary TB.


Date added: September 9, 2012 - Views: 18

Principles of Field Investigation - Rutgers University

Prevention of TB in Children: ... (60%) develop TB disease Two after initial negative PPD (Missed opportunity) 1 TB meningitis, 2 miliary 6/15 (40%) have LTBI 3/18 (17%) are TB-exposed but not infected Through 3 generations: All 2nd and 3rd generation cases preventable #3.


Date added: November 5, 2013 - Views: 3

Infection Control Update for Surveyors - Michigan

* Task specific * Task specific * Task specific * Task specific * Task specific * Task specific * Task specific * TB blood tests (also ... Body Systems CNS Spinal Tap Management and treatment of a patient with known or suspected bacterial meningitis Management of patient with prion ...


Date added: September 14, 2012 - Views: 61

Good Morning! - LSU Health Sciences Center New Orleans

TB meningitis < 1/2 serum, often < 10 >100. 50-500. Lymphocyte predominant. Negative. Imaging? ** CT of the head is necessary before LP in patients with signs or symptoms of increased ICP and should be considered for ...


Date added: August 12, 2013 - Views: 5

Tuberculosis - KSU

Tuberculosis Background Tuberculosis (TB) is the most common cause of infection-related death worldwide Mycobacterium tuberculosis is the most common cause of TB Very rare causes are Mycobacterium bovis and Mycobacterium africanum It is a very hardy bacillus that can survive under adverse ...


Date added: August 6, 2013 - Views: 4

Bloodborne Pathogens - Iredell County

Sexual contact Tuberculosis (TB) Method of Transmission: Tuberculosis (TB) is spread person to person via air. Meningitis Methods of Transmission: Direct contact with respiratory secretions Indirect contact ...


Date added: September 18, 2012 - Views: 16

TB and HIV Coinfection: What Every Health Care Professional ...

Title: TB and HIV Coinfection: What Every Health Care Professional Should Know Author: Vipra Ghimire Last modified by: Vipra Ghimire Created Date


Date added: March 28, 2014 - Views: 2

CNS Tuberculosis - University of South Carolina

Introduction CNS TB is a granulomatous infection caused by Mycobacterium tuberculosis It is hematogenously ... and parenchymal involvement * Picture 1. Tuberculosis, CNS. Contrast-enhanced CT scan in a patient with tuberculosis meningitis demonstrates marked enhancement in the basal ...


Date added: November 14, 2011 - Views: 33

Mycobacterium tuberculosis treatment - School of Medicine

Drug tx of Pulmonary TB 09/10/07 ... useful in TB meningitis as good meningeal penetration) [Combination=RIFATER] If resistance likely add ethambutol (if previous TB, immunosuppressed, in contact with organism likely to be drug resistant) ...


Date added: November 11, 2011 - Views: 46