Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.
Author(s): Magisetty Obulesu
Publisher: Academic Press
Year: 2021
Language: English
Pages: 186
City: London
Front-Matter_2021_Turmeric-and-Curcumin-for-Neurodegenerative-Diseases
Front Matter
Copyright_2021_Turmeric-and-Curcumin-for-Neurodegenerative-Diseases
Copyright
Author-biography_2021_Turmeric-and-Curcumin-for-Neurodegenerative-Diseases
Author biography
Chapter-One---Health-benefits-of-turmeric-_2021_Turmeric-and-Curcumin-for-Ne
Health benefits of turmeric: Emphasis on anticancer activity
Contents
Introduction
Gun puffing
Curcumin
Anticancer efficacy of curcumin
Colorectal cancer
Renal, bone, and lung cancer
Blood and other cancers
Antioxidant and antiinflammatory activity
Noncurcuminoids
Turmerones
Elemenes
β-Elemene
Furanodiene, furanodienone, curcumol, and calebin A
Conclusions and future perspectives
References
Further reading
Chapter-Two---Turmeric-products-in-A_2021_Turmeric-and-Curcumin-for-Neurodeg
Turmeric products in Alzheimers disease
Contents
Introduction
Alzheimers disease pathology
Natural compounds
Curcumin
Volatile essential oils of curcumin
Studies on human subjects
Metal-chelation by curcumin
Antiamyloidogenic activity
Amyloid beta
Signaling
Curcumin analogs
Theracurmin
Shortcomings in therapeutic efficacy of curcumin
In vitro studies
In vivo studies
Conclusions and future perspectives
References
Further reading
Chapter-Three---Curcumin-in-Alzheimer-s-d_2021_Turmeric-and-Curcumin-for-Neu
Curcumin in Alzheimers disease diagnosis and treatment
Contents
Introduction
Curcumin
Curcumins influence on enzymes
Curcumin and resveratrol
Oxidative damage
Chemistry and metabolism
Inflammation
Curcumin in Alzheimers disease diagnosis
Studies on humans
Amyloid interaction
Conclusions and future perspectives
References
Chapter-Four---Curcumin-loaded-drug-delivery-_2021_Turmeric-and-Curcumin-for
Curcumin loaded drug delivery systems in the treatment of Alzheimers disease
Contents
Introduction
Curcumin
Tau inhibition
Challenges
Curcumin delivery systems
Polymeric nanoparticles
Poly(lactic-co-glycolic acid)
Surface modification
Chitosan
Micelles
Phytosomes
Lipid-based nanocarriers
Liposomes
Liquid crystalline nanocarriers
Solid lipid nanoparticles
Nanostructured lipid carriers
Magnetic nanoparticles
Theranostic approach of curcumin
Conclusions and future perspectives
References
Chapter-Five---Turmeric-products-in-Par_2021_Turmeric-and-Curcumin-for-Neuro
Turmeric products in Parkinsons disease treatment
Contents
Introduction
α-Synuclein
Therapeutics
Turmeric
Turmerone
Furanodiene
Curcumin
α-Synuclein
In vitro
In vivo models
Drosophila model
Antioxidant activity
Curcumin against inflammation
Neuronal apoptosis
Curcumin analogs
Conclusions and future perspectives
References
Further reading
Chapter-Six---Curcumin-in-Parkinson-_2021_Turmeric-and-Curcumin-for-Neurodeg
Curcumin in Parkinsons disease treatment
Contents
Introduction
Drugs
Polyphenols
α-Synuclein
Curcumin
In vivo studies
Drosophila
Autophagy
Autophagy in Parkinsons disease
Curcumin analogs
Cyclocurcumin
Tetrahydrocurcumin
CNB-001
Conclusions and future perspectives
References
Chapter-Seven---Curcumin-loaded-drug-deliv_2021_Turmeric-and-Curcumin-for-Ne
Curcumin loaded drug delivery systems in Parkinsons disease
Contents
Introduction
Blood-brain barrier
Curcumin
Challenges in curcumins therapeutic efficacy
Drug delivery systems
Nanoformulations of curcumin
Polymeric nanoparticles
Micelles
Liposomes
Solid lipid nanoparticles
Surface functionalization
Conclusions and future perspectives
References
Further reading
Chapter-Eight---Turmeric-products-in-l_2021_Turmeric-and-Curcumin-for-Neurod
Turmeric products in liver disease treatment
Contents
Introduction
Liver diseases
Nonalcoholic fatty liver disease
Oxidative stress in liver diseases
Drugs
Natural products
Turmeric
Composition
Therapeutic efficacy of turmeric
Clinical trials
Turmeric products
Essential oils of turmeric
Curcumin
Oxidative liver damage
Elemene
Conclusions and future perspectives
References
Chapter-Nine---Curcumin-in-liver-di_2021_Turmeric-and-Curcumin-for-Neurodege
Curcumin in liver disease treatment
Contents
Introduction
Pathology of liver fibrosis
Drugs and liver
Curcumin
Curcumin counters liver damage
Protective efficacy of curcumin against liver-fibrosis and cirrhosis
Liver cirrhosis
Role of curcumin in nonalcoholic steatohepatitis
Role of curcumin in alcoholic liver disease
Role of curcumin against oxidative liver damage
Animal models
Conclusions and future perspectives
References
Chapter-Ten---Curcumin-loaded-drug-delivery-_2021_Turmeric-and-Curcumin-for-
Curcumin loaded drug delivery systems in the treatment of liver diseases
Contents
Introduction
Curcumin
Challenges in curcumins therapeutic efficacy and strategies to overcome
Drug delivery systems
Cancer
Hepatic fibrosis
Nanoparticles targeted against liver inflammation
Conclusions and future perspectives
References
Index_2021_Turmeric-and-Curcumin-for-Neurodegenerative-Diseases
Index
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